Application value research of swallowing treatment device combined with swallowing rehabilitation training in the treatment of swallowing disorders after stroke

BACKGROUND Stroke is a common disabling disease,whether it is ischemic stroke or hemorrhagic stroke,both can result in neuronal damage,leading to various manifestations of neurological dysfunction.AIM To explore of the application value of swallowing treatment device combined with swallowing rehabilitation training in the treatment of swallowing disorders after stroke.METHODS This study selected 86 patients with swallowing disorders after stroke admitted to our rehabilitation department from February 2022 to December 2023 as research subjects.They were divided into a control group(n=43)and an observation group(n=43)according to the treatment.The control group received swallowing rehabilitation training,while the observation group received swallowing treatment device in addition to the training.Both groups underwent continuous intervention for two courses of treatment.RESULTS The total effective rate in the observation group(93.02%)was higher than that in the control group(76.74%)(P=0.035).After intervention,the oral transit time,swallowing response time,pharyngeal transit time,and laryngeal closure time decreased in both groups compared to before intervention.In the observation group,the oral transit time,swallowing response time,and pharyngeal transit time were shorter than those in the control group after intervention.However,the laryngeal closure time after intervention in the observation group was compared with that in the control group(P=0.142).After intervention,average amplitude value and duration of the genioglossus muscle group during empty swallowing and swallowing 5 mL of water are reduced compared to before intervention in both groups.After intervention,the scores of the chin-tuck swallowing exercise and the Standardized Swallowing Assessment are both reduced compared to pre-intervention levels in both groups.However,the observation group scores lower than the control group after intervention.Additionally,the Functional Oral Intake Scale scores of both groups are increased after intervention compared to pre-intervention levels,with the observation group scoring higher than the control group after intervention(P<0.001).The cumulative incidence of complications in the observation group is 9.30%,which is lower than the 27.91%in the control group(P=0.027).CONCLUSION The combination of swallowing therapy equipment with swallowing rehabilitation training can improve the muscle movement level of the genioglossus muscle group,enhance swallowing function,and prevent the occurrence of swallowing-related complications after stroke.

Exploring the mechanism of active ingredients of Smilacis Glabrae Rhizoma in treating migraine headache through network pharmacology and animal experiments

Background:To explore the potential mechanism of action of the active ingredients of Smilacis Glabrae Rhizoma(SGR)in the treatment of migraine using network pharmacology and in vivo experiments.Methods:Through the search of Traditional Chinese Medicines Systems Pharmacology Database and Analysis Platform,Genecards,Drugbank and other databases,we obtained active ingredients,targets of SGR and related disease targets of migraine,and took the intersection for protein-protein interactions analysis.After constructing the network diagram,network topology analysis was performed to derive the core targets and key active ingredients,and Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed.Finally,molecular docking was performed and validated by in vivo experiments.In vivo experiments,18 male BALB/c mice were selected,and the SGR group was fed with SGR drinking tablet concentrate,and nitroglycerin injection was used to construct a mouse model of migraine.Enzyme-linked immunosorbent assay test was used to detect the levels of TNF-α,IL-1β,IL-6,and AKT1 in plasma.Results:The results showed that the core targets of SGR for the treatment of migraine were TNF-α,IL-1β,IL-6,and AKT1.These core targets and key active ingredients had better binding ability.Compared with the blank group,the number of head scratching in the model group increased.Compared with the model group,there was a significant reduction of the number of head scratching in the SGR group.In comparison with the blank group,the protein level in the plasma in the model group was markedly higher.Compared with the model group,the protein level in the SGR group was significantly lower.Conclusion:SGR has the characteristics of improving migraine based on multi-targets,multi-components and multi-pathways,and the mechanism of action may be related to the inhibition of the release of inflammatory factors,neuron protection,and interference with apoptosis and other processes.

Application of Comprehensive Health Education in Nursing of Patients with Metrorrhagia and Metrostaxis Treated by Hysteroscopic Electrotomy

Objective:To explore the application of health education in the nursing care of patients with metrorrhagia and metrostaxis after hysteroscopic electrotomy and the effect on the occurrence of disease complications.Methods:Totally 70 patients admitted from March 2018 to March 2019 were randomly divided into two groups.The control group was given routine nursing,while the observation group was given comprehensive health education combined with routine nursing.The unhealthy emotions(anxiety and depression)of patients were assessed using Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA).The incidence of complications,and surgical related matters were recorded and compared between two groups after nursing interventions.Results:A lower HAMD score,A lower HAMA score,a shorter hospitalization time,a shorter operation time and a less intraoperative bleeding volume,a lower incidence rate of complications(massive bleeding and uterine perforation),and a higher degree of patients’cooperation in surgery were shown in observation group compared with control group after nursing intervention(P all<0.05).Conclusion:The application of health education in the nursing of metrorrhagia and metrostaxis patients can relieve the patients’anxiety and depression,improve their understanding and mastery of relevant disease knowledge and their ability to cope with bleeding and their self-health care,as well as reduce the incidence of complications and the length of hospital stay and promote the rehabilitation of patients.Therefore,it is worthy of clinical application.

The Present Scenario, Challenges, and Future Anticipation of Traditional Mongolian Medicine in China

The objective was to study the present scenario,challenges,and future anticipation of traditional Mongolian medicine(TMM)in China.The literature was retrieved using various sources of information such as meetings with TMM experts,research and review articles,national health databases,and government websites and authoritative papers.Health care using TMM,TMM education and research,and the pharmaceutical industry of TMM has been improved by implementing TMM growth policies.TMM has been extensively used for health care in Mongolia and in various regions of China including Beijing.The national education system of China contains a stream of TMM education.There is a yearly increase in research productivity in the field of TMM due to extensive research funding by the government.The rapidly growing pharmaceutical industry of TMM has provided more availability of TMM to more patients.The literature search revealed good preservation and development of TMM in China,urging the need to take steps for the promotion of its spread and development in China and worldwide.