Mechanical forces shape the development,function,and survival of every cell within the central nervous system(CNS)but are particularly important for astroglia,a subtype of glial cell that mediates communication betwee...Mechanical forces shape the development,function,and survival of every cell within the central nervous system(CNS)but are particularly important for astroglia,a subtype of glial cell that mediates communication between neurons and blood vessels.展开更多
The structural basis of the regulation of serotonin(5-hydroxy-tryptamine,5-HT)receptors by ligands and lipids is only emerging.A recent study by Xu and colleagues1 published in Nature addresses this issue by resolving...The structural basis of the regulation of serotonin(5-hydroxy-tryptamine,5-HT)receptors by ligands and lipids is only emerging.A recent study by Xu and colleagues1 published in Nature addresses this issue by resolving five structures of 5-HT;receptor-G protein complexes.These include 5-HT1A in the apostate,i.e.not bound to a ligand,5-HT1A and 5-HT1D bound to serotonin or the atypical antipsychotic aripiprazole(for 5-HT1A),and 5-HT1E bound to its selective agonist BRL-54443.展开更多
基金supported by the National Institutes of Health(R01EY027920:Cellular and Molecular Mechanisms that Contribute to Pressure-Induced Retinal Inflammation to DK),EY027920Molecular mechanisms of mechanotransduction in the aqueous outflow pathway(to DK),T32EY024234+3 种基金Vision Research Training award(to JMB and CNR),P30EY014800Vision Core Grant at the University of Utah(to DK)Stauss-Rankin Foundation(to DK)an Unrestricted Grant from Research to Prevent Blindness to the Department of Ophthalmology at the University of Utah。
文摘Mechanical forces shape the development,function,and survival of every cell within the central nervous system(CNS)but are particularly important for astroglia,a subtype of glial cell that mediates communication between neurons and blood vessels.
基金A.D.was supported by Bundesministerium fur Bildung und Forschung(BMBF:Energl project,TP 5,01GQ1421A),Deutsche Forschungsgemeinschaft(DFG:SFB 1436,TP AOS-Project-ID 425899996)E.P.was supported by DFG grant P0732+1 种基金MZ.was supported by DFG(FOR 2858,TP B1-Project-ID 422185457)the European Research Council(ERC)under the EU Horizon 2020 research and innovation program(grant agreement no.787679).
文摘The structural basis of the regulation of serotonin(5-hydroxy-tryptamine,5-HT)receptors by ligands and lipids is only emerging.A recent study by Xu and colleagues1 published in Nature addresses this issue by resolving five structures of 5-HT;receptor-G protein complexes.These include 5-HT1A in the apostate,i.e.not bound to a ligand,5-HT1A and 5-HT1D bound to serotonin or the atypical antipsychotic aripiprazole(for 5-HT1A),and 5-HT1E bound to its selective agonist BRL-54443.
