1. Introduction In recent years, the need to face major global challenges has made it necessary to review strategies that address multifaceted contexts. Economic, societal, environnlental, and technological dimensions...1. Introduction In recent years, the need to face major global challenges has made it necessary to review strategies that address multifaceted contexts. Economic, societal, environnlental, and technological dimensions all act together as major drivers for change, and science and technology （S＆T） programs aimed at research and development （R＆D）-performing communities constitute an impor- tant asset in generating emerging and breakthrough solutions in the international transition toward the knowledge economy.展开更多
Burns are among the most challenging injuries to manage.Although the great advances in treatment that have been made have arguably been sufficient to address the related medical challenges of the past century,modern s...Burns are among the most challenging injuries to manage.Although the great advances in treatment that have been made have arguably been sufficient to address the related medical challenges of the past century,modern society now faces even greater difficulties.These are caused pre-dominantly by increase in population and lifespan,which frequently are not matched by an increased effectiveness in the maintenance of health and quality of life.展开更多
This study concerns the synthesis of gel materials based on carbon nanotubes dispersed strontium-modified hydroxyapatite(Sr-HA)at different compositions obtained by sol–gel technology and their influence on human-bon...This study concerns the synthesis of gel materials based on carbon nanotubes dispersed strontium-modified hydroxyapatite(Sr-HA)at different compositions obtained by sol–gel technology and their influence on human-bone-marrow-derived mesenchymal stem cells.Furthermore,an evaluation of the influence of nanotubes and Strontium on physico-chemical,morphological,rheological and biological properties of hydroxyapatite gel was also performed.Morphological analysis(scanning electron microscopy)shows a homogeneous distribution of modified nanotubes in the ceramic matrix improving the bioactive properties of materials.The biological investigations proved that Sr-HA/carbon nanotube gel containing 0–20 mol(%)of Sr showed no toxic effect and promote the expression of early and late markers of osteogenic differentiation in cell culture performed in basal medium without osteogenic factors.Finally,the SrHA/carbon nanotube gels could have a good potential application as filler in bone repair and regeneration and may be used in the osteoporotic disease treatment.展开更多
文摘1. Introduction In recent years, the need to face major global challenges has made it necessary to review strategies that address multifaceted contexts. Economic, societal, environnlental, and technological dimensions all act together as major drivers for change, and science and technology （S＆T） programs aimed at research and development （R＆D）-performing communities constitute an impor- tant asset in generating emerging and breakthrough solutions in the international transition toward the knowledge economy.
文摘Burns are among the most challenging injuries to manage.Although the great advances in treatment that have been made have arguably been sufficient to address the related medical challenges of the past century,modern society now faces even greater difficulties.These are caused pre-dominantly by increase in population and lifespan,which frequently are not matched by an increased effectiveness in the maintenance of health and quality of life.
基金supported through funds provided by the PNR-CNR Aging Program 2012-2014.
文摘This study concerns the synthesis of gel materials based on carbon nanotubes dispersed strontium-modified hydroxyapatite(Sr-HA)at different compositions obtained by sol–gel technology and their influence on human-bone-marrow-derived mesenchymal stem cells.Furthermore,an evaluation of the influence of nanotubes and Strontium on physico-chemical,morphological,rheological and biological properties of hydroxyapatite gel was also performed.Morphological analysis(scanning electron microscopy)shows a homogeneous distribution of modified nanotubes in the ceramic matrix improving the bioactive properties of materials.The biological investigations proved that Sr-HA/carbon nanotube gel containing 0–20 mol(%)of Sr showed no toxic effect and promote the expression of early and late markers of osteogenic differentiation in cell culture performed in basal medium without osteogenic factors.Finally,the SrHA/carbon nanotube gels could have a good potential application as filler in bone repair and regeneration and may be used in the osteoporotic disease treatment.
