Mechanical force between cells relates to many biological processes of cell development.The cellular collective migration comes from cell-cell cooperation,and studying the intercellular mechanical properties helps elu...Mechanical force between cells relates to many biological processes of cell development.The cellular collective migration comes from cell-cell cooperation,and studying the intercellular mechanical properties helps elucidate collective cell migration.Herein,we studied cell-cell junctions,intercellular tensile force and the related cellular energetic costs in confined microchannels.Using the intercellular force sensor,we found that cells adapt to different confinement environments by regulating intercellular force,and thereby the relationship between collective cell migration and cell-cell junction were verified.Through the observation of cell orientation,actomyosin contractility,energetic costs,and glucose uptake,we can make a reasonable explanation of cell-force driven migration in different confined environments.Under highly confined conditions,the intercellular force and energetic costs are greater,and the cell orientation is more orderly.The collective migration behavior in confined spaces is closely related to the intercellular force and energetic costs,which is helpful to understand the collective migration behaviors in various confined spaces.展开更多
In this paper, the effects of three types of commonly used adhesives were studied via experiment and simulation. The results show that the strain sensitivity of fiber Bragg grating(FBG) sensor is about 1.201 pm/με a...In this paper, the effects of three types of commonly used adhesives were studied via experiment and simulation. The results show that the strain sensitivity of fiber Bragg grating(FBG) sensor is about 1.201 pm/με and the effects of three adhesives of epoxy resin, AB glue and 502 glue with the same thickness and length on sensitivity coefficients of FBG sensors are 99.20%, 93.80% and 96.50%, respectively. Finally, the sensitivity coefficient of the simulated FBG sensor is the same as the test result by ANSYS modeling.展开更多
基金supported by the National Natural Science Foundation of China(No.22034003)Excellent Research Program of Nanjing University(No.ZYJH004)+2 种基金Fundamental Research Funds for the Central Universities(No.020514380181)State Key Laboratory of Analytical Chemistry for Life Science(No.5431ZZXM2002)Program B for Outstanding PhD candidate of Nanjing University(No.201702B052)。
文摘Mechanical force between cells relates to many biological processes of cell development.The cellular collective migration comes from cell-cell cooperation,and studying the intercellular mechanical properties helps elucidate collective cell migration.Herein,we studied cell-cell junctions,intercellular tensile force and the related cellular energetic costs in confined microchannels.Using the intercellular force sensor,we found that cells adapt to different confinement environments by regulating intercellular force,and thereby the relationship between collective cell migration and cell-cell junction were verified.Through the observation of cell orientation,actomyosin contractility,energetic costs,and glucose uptake,we can make a reasonable explanation of cell-force driven migration in different confined environments.Under highly confined conditions,the intercellular force and energetic costs are greater,and the cell orientation is more orderly.The collective migration behavior in confined spaces is closely related to the intercellular force and energetic costs,which is helpful to understand the collective migration behaviors in various confined spaces.
基金supported by the Scientific Research Project of Hefei Normal University(No.2017QN14)the National Innovation Training Program of Hefei Normal University in 2018(No.201814098045)
文摘In this paper, the effects of three types of commonly used adhesives were studied via experiment and simulation. The results show that the strain sensitivity of fiber Bragg grating(FBG) sensor is about 1.201 pm/με and the effects of three adhesives of epoxy resin, AB glue and 502 glue with the same thickness and length on sensitivity coefficients of FBG sensors are 99.20%, 93.80% and 96.50%, respectively. Finally, the sensitivity coefficient of the simulated FBG sensor is the same as the test result by ANSYS modeling.
