Treatment of large bone defects derived from bone tumor surgery is typically performed in multiple separate operations,such as hyperthermia to extinguish residual malignant cells or implanting bioactive materials to i...Treatment of large bone defects derived from bone tumor surgery is typically performed in multiple separate operations,such as hyperthermia to extinguish residual malignant cells or implanting bioactive materials to initiate apatite remineralization for tissue repair;it is very challenging to combine these functions into a material.Herein,we report the first photothermal(PT)effect in bismuth(Bi)-doped glasses.On the basis of this discovery,we have developed a new type of Bi-doped bioactive glass that integrates both functions,thus reducing the number of treatment cycles.We demonstrate that Bi-doped bioglasses(BGs)provide high PT efficiency,potentially facilitating photoinduced hyperthermia and bioactivity to allow bone tissue remineralization.The PT effect of Bi-doped BGs can be effectively controlled by managing radiative and non-radiative processes of the active Bi species by quenching photoluminescence(PL)or depolymerizing glass networks.In vitro studies demonstrate that such glasses are biocompatible to tumor and normal cells and that they can promote osteogenic cell proliferation,differentiation,and mineralization.Upon illumination with near-infrared(NIR)light,the bioglass(BG)can efficiently kill bone tumor cells,as demonstrated via in vitro and in vivo experiments.This indicates excellent potential for the integration of multiple functions within the new materials,which will aid in the development and application of novel biomaterials.展开更多
In recent years,noncoding gene(NCG)translation events have been frequently discovered.The resultant peptides,as novel findings in the life sciences,perform unexpected functions of increasingly recognized importance in...In recent years,noncoding gene(NCG)translation events have been frequently discovered.The resultant peptides,as novel findings in the life sciences,perform unexpected functions of increasingly recognized importance in many fundamental biological and pathological processes.The emergence of these novel peptides,in turn,has advanced the field of genomics while indispensably aiding living organisms.The peptides from NCGs serve as important links between extracellular stimuli and intracellular adjustment mechanisms.These peptides are also important entry points for further exploration of the mysteries of life that may trigger a new round of revolutionary biotechnological discoveries.Insights into NCG-derived peptides will assist in understanding the secrets of life and the causes of diseases,and will also open up new paths to the treatment of diseases such as cancer.Here,a critical review is presented on the action modes and biological functions of the peptides encoded by NCGs.The challenges and future trends in searching for and studying NCG peptides are also critically discussed.展开更多
In this originally published article,we have noticed several mistakes.They should be corrected as follows:1.On page 1,the second affiliation(No.5)of the author“Chuanbin Mao”should be deleted as he does not belong to...In this originally published article,we have noticed several mistakes.They should be corrected as follows:1.On page 1,the second affiliation(No.5)of the author“Chuanbin Mao”should be deleted as he does not belong to that affiliation.Namely,he should be only listed with(Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center,University of Oklahoma,Norman,OK 73072,USA).展开更多
基金Acknowledgements This study was supported by grants from the National Natural Science Foundation of China （No. 81028010）, Ministry of Science and Technology （No. 2014DFA31740） and the Department of Science and Technology of Jilin Province, China （Nos. 20130206009YY and 20130727034YY）. Y. Z., Z. G. J., P. H. Q. and C. B. M. also would like to thank the financial support from National Sdence Foundation （Nos. CMMI-1234957 and CBET-1512664）, National Institutes of Health （Nos. EB015190 and CA200504）, Department of Defense Peer Reviewed Medical Research Program （No. W81XWH- 12-1-0384）, Oklahoma Center for the Advancement of Science and Technology （No. HR14-160） and Oklahoma Center for Adult Stem Cell Research （No. 434003）.
基金financial support from the Program for Innovative Research Team in University of Ministry of Education of China(Grant No.IRT_17R38)the National Natural Science Foundation of China(Grant No.51672085)+2 种基金the Key Program of Guangzhou Scientific Research Special Projects(Grant No.201607020009)the Joint Fund of Ministry of Education of Chinathe Fundamental Research Funds for the Central Universities.
文摘Treatment of large bone defects derived from bone tumor surgery is typically performed in multiple separate operations,such as hyperthermia to extinguish residual malignant cells or implanting bioactive materials to initiate apatite remineralization for tissue repair;it is very challenging to combine these functions into a material.Herein,we report the first photothermal(PT)effect in bismuth(Bi)-doped glasses.On the basis of this discovery,we have developed a new type of Bi-doped bioactive glass that integrates both functions,thus reducing the number of treatment cycles.We demonstrate that Bi-doped bioglasses(BGs)provide high PT efficiency,potentially facilitating photoinduced hyperthermia and bioactivity to allow bone tissue remineralization.The PT effect of Bi-doped BGs can be effectively controlled by managing radiative and non-radiative processes of the active Bi species by quenching photoluminescence(PL)or depolymerizing glass networks.In vitro studies demonstrate that such glasses are biocompatible to tumor and normal cells and that they can promote osteogenic cell proliferation,differentiation,and mineralization.Upon illumination with near-infrared(NIR)light,the bioglass(BG)can efficiently kill bone tumor cells,as demonstrated via in vitro and in vivo experiments.This indicates excellent potential for the integration of multiple functions within the new materials,which will aid in the development and application of novel biomaterials.
基金This work was supported by the China National Funds for Distinguished Young Scientists(81425019)the State Key Program of National Natural Science Foundation of China(81730076)+4 种基金Shanghai Science and Technology Committee Program no.18XD1405300the Specially Appointed Professor Fund of Shanghai(GZ2015009)We also thank the financial fund from Shanghai Key Laboratory of Medical Biodefense,Shanghai,ChinaS.R.L.also thank the State Key Laboratory of Oncogenes and Related Genes(90-17-04)for fundingC.B.M.would thanks the National Institutes of Health(EB021339)for financial support.
文摘In recent years,noncoding gene(NCG)translation events have been frequently discovered.The resultant peptides,as novel findings in the life sciences,perform unexpected functions of increasingly recognized importance in many fundamental biological and pathological processes.The emergence of these novel peptides,in turn,has advanced the field of genomics while indispensably aiding living organisms.The peptides from NCGs serve as important links between extracellular stimuli and intracellular adjustment mechanisms.These peptides are also important entry points for further exploration of the mysteries of life that may trigger a new round of revolutionary biotechnological discoveries.Insights into NCG-derived peptides will assist in understanding the secrets of life and the causes of diseases,and will also open up new paths to the treatment of diseases such as cancer.Here,a critical review is presented on the action modes and biological functions of the peptides encoded by NCGs.The challenges and future trends in searching for and studying NCG peptides are also critically discussed.
文摘In this originally published article,we have noticed several mistakes.They should be corrected as follows:1.On page 1,the second affiliation(No.5)of the author“Chuanbin Mao”should be deleted as he does not belong to that affiliation.Namely,he should be only listed with(Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center,University of Oklahoma,Norman,OK 73072,USA).
