4,4'-Dimethoxy-5,6,5',6'-dimethenedioxy-2,2'-dimethoxycarbonyl biphenyl (DDB, 1) and its derivatives show anti-HBV and anti-HIV activities.[1] However, their poor solubility was not in favor of bio... 4,4'-Dimethoxy-5,6,5',6'-dimethenedioxy-2,2'-dimethoxycarbonyl biphenyl (DDB, 1) and its derivatives show anti-HBV and anti-HIV activities.[1] However, their poor solubility was not in favor of bioavailability.[2,3] In addition,other anti-HIV agents[4] with piperazine moiety have been investigated. Their saturated nitrogen-containing heterocyclic groups play the role of pharmaco-effectivity.[5] It was assumed that the combination of DDB with substituted benzyl piperazines would produce some new compounds with activity against anti-HIV. Therefore, we designed and synthesized a class of novel 4,4'-dimethoxy-5,6,5',6'-dimethenedioxy biphenyls modified by substituted piperazines, and partly evaluated their anti-SIV activity.……展开更多
文摘 4,4'-Dimethoxy-5,6,5',6'-dimethenedioxy-2,2'-dimethoxycarbonyl biphenyl (DDB, 1) and its derivatives show anti-HBV and anti-HIV activities.[1] However, their poor solubility was not in favor of bioavailability.[2,3] In addition,other anti-HIV agents[4] with piperazine moiety have been investigated. Their saturated nitrogen-containing heterocyclic groups play the role of pharmaco-effectivity.[5] It was assumed that the combination of DDB with substituted benzyl piperazines would produce some new compounds with activity against anti-HIV. Therefore, we designed and synthesized a class of novel 4,4'-dimethoxy-5,6,5',6'-dimethenedioxy biphenyls modified by substituted piperazines, and partly evaluated their anti-SIV activity.……
