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A new b/aLEN-17 gene in a clinical isolate of Staphylococcus epidermidis in Shanghai, China 被引量:1
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作者 SHENG Hai-hui QU Yi +8 位作者 WU Xue-mei DONG Yuan-yuan ZENG Xian-ting CAO Huan HUANG Xiao-Wei YIN Han-qi YU Ya-qing NI Yu-xing XIAO Hua-sheng 《Chinese Medical Journal》 SCIE CAS CSCD 2008年第3期272-275,共4页
The introduction of the antibiotics into clinical practice has significantly reduced the mortality of infectious diseases. Although chromosomally mediated β-1actamase is natural in many genera of bacteria, the intens... The introduction of the antibiotics into clinical practice has significantly reduced the mortality of infectious diseases. Although chromosomally mediated β-1actamase is natural in many genera of bacteria, the intensive use of antibiotics is the main cause for the increasing emergence of new β-1actamases. So far, more than 340 β-lactamases have been identified,1 among which, more than 200 are extended-spectrum β-lactamases (ESBLs).2 The most prevalent β-lactamases are class A enzymes, including SHV and TEM. Genes encoding these enzymes generally located in large transferable plasmids. The dissemination of these plasmids attributes to the increasing incidence and spread of v-lactam resistance. It is important to investigate the prevalence and allelic distribution of genes encoding β-lactamase in the bacterial population in order to prevent the emergence of ESBLs in those bacteria and the spread of ESBLs in the clinical setting. 展开更多
关键词 Β-LACTAMASE LEN GENOTYPING Staphylococcus epidermidis
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