Multiple studies have reported decreased emergency department(ED)patient volumes during the coronavirus disease(COVID-19)pandemic,[1-6]including areas most affected by the virus.[7]Most existing studies have investiga...Multiple studies have reported decreased emergency department(ED)patient volumes during the coronavirus disease(COVID-19)pandemic,[1-6]including areas most affected by the virus.[7]Most existing studies have investigated general trends in ED presentations and have not examined the impact of COVID-19 on different types of EDs,specific ED patient groups,or illness presentations.展开更多
Introduction: Cancer is a chronic debilitating disease that unnerves patients, communities, and nations. At some point in cancer patient’s disease experience, chemotherapy is used, and the patient is expected to adhe...Introduction: Cancer is a chronic debilitating disease that unnerves patients, communities, and nations. At some point in cancer patient’s disease experience, chemotherapy is used, and the patient is expected to adhere to treatment to improve survival and quality of life. Methods: This multisite Cluster Randomized Trial (CRT) evaluated the effectiveness of mobile phone Short Message Service (SMS) support on the adherence to treatment schedules among adult cancer patients in Kenya. Data was collected using questionnaires. Ethical approvals were obtained from relevant Ethical Review Boards (ERBs). Results: The mean adherence was 83%. There was a significant difference between treatment arms in relation to the adherence. The intervention arm had a higher mean adherence difference, M = 3.913, 95% CI 2.632-5.193, t (402) = 6.006, p ≤ 0.001), with Cohen’s d = 0.60. Although not significant, (χ<sup>2</sup>dd = 0.151, df = 1, p = 2.064), more women were perfect adheres than males. Perfect adherers were satisfied with SMS support (χ<sup>2</sup>dd = 7.620, df = 1, p = 0.06), were in the intervention arm (χ<sup>2</sup>dd = 22.942, df = 1, p ≤ 0.001), and had trust in the care provider (χ<sup>2</sup>dd = 10.591 p ≤ 0.001). SMS support was not significant in the multivariate analysis but had an estimated effect size of 0.958 (z = 1.424, p = 0.154, CI = 0.242-3.781), indicating that mean adherence was slightly better in the presence of the intervention. Conclusions: SMS-support intervention has demonstrated superiority in influencing adherence. Further, health system-related factors have a significant influence on the adherence to chemotherapy treatment. Interventions to re-design health systems that are responsive to unmet care needs of cancer patients must be explored. .展开更多
Using the hydrological and meteorological data in the Kaidu River Basin during 1957-2008, we simulated the hydro-climatic process by back-propagation artificial neural network (BPANN) based on wavelet analysis (WA...Using the hydrological and meteorological data in the Kaidu River Basin during 1957-2008, we simulated the hydro-climatic process by back-propagation artificial neural network (BPANN) based on wavelet analysis (WA), and then compared the simulated results with those from a multiple linear regression (MLR). The results show that the variation of runoff responded to regional climate change. The annual runoff (AR) was mainly affected by annual average temperature (AAT) and annual precipitation (AP), which revealed different varia- tion patterns at five time scales. At the time scale of 32-years, AR presented a monotonically increasing trend with the similar trend of AAT and AP. But at the 2-year, 4- year, 8-year, and 16-year time-scale, AR presented non-linear variation with fluctuations of AAT and AP. Both MLR and BPANN successfully simulated the hydro- climatic process based on WA at each time scale, but the simulated effect from BPANN is better than that from MLR.展开更多
CONSPECTUS:The development of a highly effective,low-cost method for protection against direct transmission through infectious media associated with respiratory diseases has been considered to be a major challenge in ...CONSPECTUS:The development of a highly effective,low-cost method for protection against direct transmission through infectious media associated with respiratory diseases has been considered to be a major challenge in the management of the pandemic outbreak.Currently,filtration in respirators and masks depends on the mesh size,raising safety concerns about direct contact with the virus-laden layers of masks and respirators during use and disposal.Also,conventional medical face masks and respirators are recommended for single use only because long-term use and reuse of masks increase the risk of contact transmission of pathogens.As a result,mask reusability has gained much attention in addressing the global problem of respirator and mask shortages during the COVID-19 pandemic.Furthermore,coinfection by influenza,SARSCoV-2,and bacteria has been an ongoing issue in the current COVID-19 pandemic.In our response to the increasing demand for more convenient forms of disease control,our group has investigated antimicrobial technologies for respiratory devices against pandemic/epidemic diseases and developed two universal antimicrobial coating technologies:(1)nonwashable,reusable salt-coated fabrics and(2)washable,photopolymerizable polymer-coated fabrics which efficiently inactivate infectious viruses by contact with the filter.This is an opportune time to assess research efforts toward antimicrobial face mask technology for its expected impact on society and the economy.展开更多
文摘Multiple studies have reported decreased emergency department(ED)patient volumes during the coronavirus disease(COVID-19)pandemic,[1-6]including areas most affected by the virus.[7]Most existing studies have investigated general trends in ED presentations and have not examined the impact of COVID-19 on different types of EDs,specific ED patient groups,or illness presentations.
文摘Introduction: Cancer is a chronic debilitating disease that unnerves patients, communities, and nations. At some point in cancer patient’s disease experience, chemotherapy is used, and the patient is expected to adhere to treatment to improve survival and quality of life. Methods: This multisite Cluster Randomized Trial (CRT) evaluated the effectiveness of mobile phone Short Message Service (SMS) support on the adherence to treatment schedules among adult cancer patients in Kenya. Data was collected using questionnaires. Ethical approvals were obtained from relevant Ethical Review Boards (ERBs). Results: The mean adherence was 83%. There was a significant difference between treatment arms in relation to the adherence. The intervention arm had a higher mean adherence difference, M = 3.913, 95% CI 2.632-5.193, t (402) = 6.006, p ≤ 0.001), with Cohen’s d = 0.60. Although not significant, (χ<sup>2</sup>dd = 0.151, df = 1, p = 2.064), more women were perfect adheres than males. Perfect adherers were satisfied with SMS support (χ<sup>2</sup>dd = 7.620, df = 1, p = 0.06), were in the intervention arm (χ<sup>2</sup>dd = 22.942, df = 1, p ≤ 0.001), and had trust in the care provider (χ<sup>2</sup>dd = 10.591 p ≤ 0.001). SMS support was not significant in the multivariate analysis but had an estimated effect size of 0.958 (z = 1.424, p = 0.154, CI = 0.242-3.781), indicating that mean adherence was slightly better in the presence of the intervention. Conclusions: SMS-support intervention has demonstrated superiority in influencing adherence. Further, health system-related factors have a significant influence on the adherence to chemotherapy treatment. Interventions to re-design health systems that are responsive to unmet care needs of cancer patients must be explored. .
文摘Using the hydrological and meteorological data in the Kaidu River Basin during 1957-2008, we simulated the hydro-climatic process by back-propagation artificial neural network (BPANN) based on wavelet analysis (WA), and then compared the simulated results with those from a multiple linear regression (MLR). The results show that the variation of runoff responded to regional climate change. The annual runoff (AR) was mainly affected by annual average temperature (AAT) and annual precipitation (AP), which revealed different varia- tion patterns at five time scales. At the time scale of 32-years, AR presented a monotonically increasing trend with the similar trend of AAT and AP. But at the 2-year, 4- year, 8-year, and 16-year time-scale, AR presented non-linear variation with fluctuations of AAT and AP. Both MLR and BPANN successfully simulated the hydro- climatic process based on WA at each time scale, but the simulated effect from BPANN is better than that from MLR.
基金The authors thank Mr.Panjae Lee for critical comments on an earlier draft of this articleThis research was financially supported by the Natural Sciences and Engineering Research Council of Canada(NSERC)Discovery Grant[RGPIN-2018-04314]+2 种基金the Li Ka Shing Canada Foundation[LKSCF]George Weston Limited[GWL SFIG SFI18-0209]University of Alberta Faculty of Engineering[UOFAB SF FAC ENG],and the Mitacs Globalink Research Award[IT12753].
文摘CONSPECTUS:The development of a highly effective,low-cost method for protection against direct transmission through infectious media associated with respiratory diseases has been considered to be a major challenge in the management of the pandemic outbreak.Currently,filtration in respirators and masks depends on the mesh size,raising safety concerns about direct contact with the virus-laden layers of masks and respirators during use and disposal.Also,conventional medical face masks and respirators are recommended for single use only because long-term use and reuse of masks increase the risk of contact transmission of pathogens.As a result,mask reusability has gained much attention in addressing the global problem of respirator and mask shortages during the COVID-19 pandemic.Furthermore,coinfection by influenza,SARSCoV-2,and bacteria has been an ongoing issue in the current COVID-19 pandemic.In our response to the increasing demand for more convenient forms of disease control,our group has investigated antimicrobial technologies for respiratory devices against pandemic/epidemic diseases and developed two universal antimicrobial coating technologies:(1)nonwashable,reusable salt-coated fabrics and(2)washable,photopolymerizable polymer-coated fabrics which efficiently inactivate infectious viruses by contact with the filter.This is an opportune time to assess research efforts toward antimicrobial face mask technology for its expected impact on society and the economy.