Abstract--- Because of rapid development in network technology, Internet usage has become widespread. It allows users with sensing devices to obtain medical data for healthcare, such as physiological signals, voice, a...Abstract--- Because of rapid development in network technology, Internet usage has become widespread. It allows users with sensing devices to obtain medical data for healthcare, such as physiological signals, voice, and video streams from telemedicine systems, and to send the healthcare data to back-end database systems, creating a ubiquitous healthcare environment. However, this environment requires a widespread and suitable network. IPv6 (Internet protocol version 6) is the next-generation Internet protocol that will be the protocol of future networks; it improves many shortcomings of IPv4. In this paper, we propose an IPv6/IPv4 U-home-care test system and analyze the network's parameters though a series of tests by adjusting network parameters to find the optimal design for applications in the IPv6/IPv4 U-home-care service so as to assure good performance and high quality.展开更多
As ubiquitous sensor networks (USN) technologies and its middleware are still at its early stages, the system of the USN relies on the middleware and applications. The past sensor networks are assumed to be designed f...As ubiquitous sensor networks (USN) technologies and its middleware are still at its early stages, the system of the USN relies on the middleware and applications. The past sensor networks are assumed to be designed for specific applications, having data communication protocols tightly coupled to applications. To avoid these problems, several kinds of USN middleware have been researched and developed. However, most middleware of USN are still restricted by its own infrastructure so far. This paper proposes appropriate 3 tier Smart Middleware System (3SMS) for USN.展开更多
Modern network systems have much trouble in security vulnerabilities such as buffer overflow, bugs in Microsoft Internet, sensor network routing protocol too simple, security flaws of applications, and operating syste...Modern network systems have much trouble in security vulnerabilities such as buffer overflow, bugs in Microsoft Internet, sensor network routing protocol too simple, security flaws of applications, and operating systems. Moreover, wireless devices such as smart phones, personal digital assistants (PDAs), and sensors have become economically feasible because of technological advances in wireless communication and manufacturing of small and low-cost sensors. There are typologies of vulnerabilities to be exploited in these devices. In order to improve securities, many mechanisms are adopted, including authentication, cryptography, access control, and intrusion detection systems (IDS). In general, intrusion detection techniques can be categorized into two groups: misuse detection and anomaly detection. The misuse detection systems use patterns of weB-known attacks or weak spots of the systems to identify intrusions. The weakness of misuse detection systems is unable to detect any future (unknown) intrusion until corresponding attack signatures are intruded into the signature database. Anomaly detection methods try to determine whether the deviation is from the established normal usage patterns or not. The critical success of anomaly detection relies on the model of normal behaviors.展开更多
By solving the 2D Poisson's equation, analytical models are proposed to calculate the surface potential and electric field distributions of lateral power devices with arbitrary vertical doping profiles. The vertical ...By solving the 2D Poisson's equation, analytical models are proposed to calculate the surface potential and electric field distributions of lateral power devices with arbitrary vertical doping profiles. The vertical and the lateral breakdown voltages are formulized to quantify the breakdown characteristic in completely-depleted and partially-depleted cases. A new reduced surface field (RESURF) criterion which can be used in various drift doping profiles is further derived for obtaining the optimal trade-off between the breakdown voltage and the on-resistance. Based on these models and the numerical simulation, the electric field modulation mechanism and the breakdown characteristics of lateral power devices are investigated in detail for the uniform, linear, Gaussian, and some discrete doping profiles along the vertical direction in the drift region. Then, the mentioned vertical doping profiles of these devices with the same geometric parameters are optimized, and the results show that the optimal breakdown voltages and the effective drift doping concentrations of these devices are identical, which are equal to those of the uniform-doped device, respectively. The analytical results of these proposed models are in good agreement with the numerical results and the previous experimental results, confirming the validity of the models presented here.展开更多
Malignant brain tumors remain difficult to treat with chemotherapy because the blood–brain barrier (BBB) limits the amounts of potent agents that can reach the tumor, such that the drugs are unable to reach therapeut...Malignant brain tumors remain difficult to treat with chemotherapy because the blood–brain barrier (BBB) limits the amounts of potent agents that can reach the tumor, such that the drugs are unable to reach therapeutic dosage. Although various targeted carriers that encapsulate chemotherapeutic agents have been shown to improve drug delivery to brain tumors, the BBB is still a major obstacle in the use of chemotherapy for the treatment of these tumors. Human glioblastoma-bearing mice were injected intravenously with doxorubicin (Dox) encapsulated in atherosclerotic plaque-specific peptide-1 (AP-1)-conjugated liposomes or unconjugated liposome. These treatments took place with or without BBB disruption induced by transcranial pulsed high-intensity focused ultrasound (pulsed HIFU). This study showed that the treatment with Dox encapsulated in AP-1-conjugated liposomes followed by pulsed HIFU enhanced the accumulation of the cytotoxic drug in cells and inhibited the growth of brain tumors in vivo. Combining pulsed HIFU with cytotoxic agents might improve their efficacy in patients with brain tumors while simultaneously reducing the drug side effects. Further investigation is required to provide a comprehensive physical characterization of the sonication process and to determine its bioeffects.展开更多
Reversible data hiding techniques are capable of reconstructing the original cover image from stego-images. Recently, many researchers have focused on reversible data hiding to protect intellectual property rights. In...Reversible data hiding techniques are capable of reconstructing the original cover image from stego-images. Recently, many researchers have focused on reversible data hiding to protect intellectual property rights. In this paper, we combine reversible data hiding with the chaotic Henon map as an encryption technique to achieve an acceptable level of confidentiality in cloud computing environments. And, Haar digital wavelet transformation (HDWT) is also applied to convert an image from a spatial domain into a frequency domain. And then the decimal of coefficients and integer of high frequency band are modified for hiding secret bits. Finally, the modified coefficients are inversely transformed to stego-images.展开更多
This paper presents an analytical three-dimensional breakdown model of SOI lateral power devices with a circular layout. The Poisson equation is solved in cylindrical coordinates to obtain the radial surface potential...This paper presents an analytical three-dimensional breakdown model of SOI lateral power devices with a circular layout. The Poisson equation is solved in cylindrical coordinates to obtain the radial surface potential and electric field distributions for both fully- and partially-depleted dr/ft regions. The breakdown voltages for N+N and P+N junctions are derived and employed to investigate the impact of cathode region curvature. A modified RESURF criterion is proposed to provide a design guideline for optimizing the breakdown voltage and doping concentration in the drift region in three dimensional space. The analytical results agree well with MEDICI simulation results and experimental data from earlier publications.展开更多
文摘Abstract--- Because of rapid development in network technology, Internet usage has become widespread. It allows users with sensing devices to obtain medical data for healthcare, such as physiological signals, voice, and video streams from telemedicine systems, and to send the healthcare data to back-end database systems, creating a ubiquitous healthcare environment. However, this environment requires a widespread and suitable network. IPv6 (Internet protocol version 6) is the next-generation Internet protocol that will be the protocol of future networks; it improves many shortcomings of IPv4. In this paper, we propose an IPv6/IPv4 U-home-care test system and analyze the network's parameters though a series of tests by adjusting network parameters to find the optimal design for applications in the IPv6/IPv4 U-home-care service so as to assure good performance and high quality.
基金This work is supported by the Second Stage of Brain Korea 21 project in 2007 .
文摘As ubiquitous sensor networks (USN) technologies and its middleware are still at its early stages, the system of the USN relies on the middleware and applications. The past sensor networks are assumed to be designed for specific applications, having data communication protocols tightly coupled to applications. To avoid these problems, several kinds of USN middleware have been researched and developed. However, most middleware of USN are still restricted by its own infrastructure so far. This paper proposes appropriate 3 tier Smart Middleware System (3SMS) for USN.
文摘Modern network systems have much trouble in security vulnerabilities such as buffer overflow, bugs in Microsoft Internet, sensor network routing protocol too simple, security flaws of applications, and operating systems. Moreover, wireless devices such as smart phones, personal digital assistants (PDAs), and sensors have become economically feasible because of technological advances in wireless communication and manufacturing of small and low-cost sensors. There are typologies of vulnerabilities to be exploited in these devices. In order to improve securities, many mechanisms are adopted, including authentication, cryptography, access control, and intrusion detection systems (IDS). In general, intrusion detection techniques can be categorized into two groups: misuse detection and anomaly detection. The misuse detection systems use patterns of weB-known attacks or weak spots of the systems to identify intrusions. The weakness of misuse detection systems is unable to detect any future (unknown) intrusion until corresponding attack signatures are intruded into the signature database. Anomaly detection methods try to determine whether the deviation is from the established normal usage patterns or not. The critical success of anomaly detection relies on the model of normal behaviors.
基金Projects supported by the National Natural Science Foundation of China (Grant No. 61076073)the Natural Science Foundation of Jiangsu Higher Education Institutions of China (Grant No. 09KJB510010)+1 种基金the Open Foundation of State Key Laboratory of Electronic Thin Films and Integrated Devices, China (Grant No. KFJJ201011)the Research and Innovation Project for College Graduates of Jiangsu Province, China (Grant No. CXZZ11 0382)
文摘By solving the 2D Poisson's equation, analytical models are proposed to calculate the surface potential and electric field distributions of lateral power devices with arbitrary vertical doping profiles. The vertical and the lateral breakdown voltages are formulized to quantify the breakdown characteristic in completely-depleted and partially-depleted cases. A new reduced surface field (RESURF) criterion which can be used in various drift doping profiles is further derived for obtaining the optimal trade-off between the breakdown voltage and the on-resistance. Based on these models and the numerical simulation, the electric field modulation mechanism and the breakdown characteristics of lateral power devices are investigated in detail for the uniform, linear, Gaussian, and some discrete doping profiles along the vertical direction in the drift region. Then, the mentioned vertical doping profiles of these devices with the same geometric parameters are optimized, and the results show that the optimal breakdown voltages and the effective drift doping concentrations of these devices are identical, which are equal to those of the uniform-doped device, respectively. The analytical results of these proposed models are in good agreement with the numerical results and the previous experimental results, confirming the validity of the models presented here.
文摘Malignant brain tumors remain difficult to treat with chemotherapy because the blood–brain barrier (BBB) limits the amounts of potent agents that can reach the tumor, such that the drugs are unable to reach therapeutic dosage. Although various targeted carriers that encapsulate chemotherapeutic agents have been shown to improve drug delivery to brain tumors, the BBB is still a major obstacle in the use of chemotherapy for the treatment of these tumors. Human glioblastoma-bearing mice were injected intravenously with doxorubicin (Dox) encapsulated in atherosclerotic plaque-specific peptide-1 (AP-1)-conjugated liposomes or unconjugated liposome. These treatments took place with or without BBB disruption induced by transcranial pulsed high-intensity focused ultrasound (pulsed HIFU). This study showed that the treatment with Dox encapsulated in AP-1-conjugated liposomes followed by pulsed HIFU enhanced the accumulation of the cytotoxic drug in cells and inhibited the growth of brain tumors in vivo. Combining pulsed HIFU with cytotoxic agents might improve their efficacy in patients with brain tumors while simultaneously reducing the drug side effects. Further investigation is required to provide a comprehensive physical characterization of the sonication process and to determine its bioeffects.
基金Supported by the National Natural Science Foundation of China under Grant 60806027, China Postdoctoral Science Foundation under Grant 20070411013, Jiangsu Provincial Natural Science Foundations under Grant No BK2007605, Foundation of Jiangsu Educational Committee under Grant 09KJB510010, and State Key Laboratory of Electronic Thin Films and Integrated Devices under Grant No KF2007001.
文摘Reversible data hiding techniques are capable of reconstructing the original cover image from stego-images. Recently, many researchers have focused on reversible data hiding to protect intellectual property rights. In this paper, we combine reversible data hiding with the chaotic Henon map as an encryption technique to achieve an acceptable level of confidentiality in cloud computing environments. And, Haar digital wavelet transformation (HDWT) is also applied to convert an image from a spatial domain into a frequency domain. And then the decimal of coefficients and integer of high frequency band are modified for hiding secret bits. Finally, the modified coefficients are inversely transformed to stego-images.
基金Project supported by the National Natural Science Foundation of China (No.60806027)the China Postdoctoral Science Foundation (No.20070411013)+1 种基金the Natural Science Foundation of Jiangsu Province,China (No.BK2007605)the State Key Laboratory of Electronic Thin Films and Integrated Devices (No.KF2007001)
文摘This paper presents an analytical three-dimensional breakdown model of SOI lateral power devices with a circular layout. The Poisson equation is solved in cylindrical coordinates to obtain the radial surface potential and electric field distributions for both fully- and partially-depleted dr/ft regions. The breakdown voltages for N+N and P+N junctions are derived and employed to investigate the impact of cathode region curvature. A modified RESURF criterion is proposed to provide a design guideline for optimizing the breakdown voltage and doping concentration in the drift region in three dimensional space. The analytical results agree well with MEDICI simulation results and experimental data from earlier publications.