Functionality of adult peripheral nerves essentially relies on differentiation of Schwann cells during post- natal development, as well as fine-tuned re- and transdifferentiation in response to peripheral nerve injury...Functionality of adult peripheral nerves essentially relies on differentiation of Schwann cells during post- natal development, as well as fine-tuned re- and transdifferentiation in response to peripheral nerve injury. Epigenetic histone modifications play a major role during the differentiation of embryonic stem cells and diverse organ specific progenitor cells, yet only little is known about the epigenetic regulation of Schwa nn cells. Just recently, Fuhrmann et al. reported how the transcription factor Myc-interacting zinc-finger protein 1 （Mizl） might contribute to Schwann cell differentiation through repression of the histone de- methylase Kdm8. Here, we discuss the potential novel role of Mizl in Schwann cell differentiation and give a short overview about previously reported histone modifications underlying peripheral nerve develop- ment and response to injury.展开更多
Peripheral motor and sensory neuropathies are diseases with different etiologies emerging from genetic disorders,diabetes,infection or inflammation,paraneoplastic damage or intoxications including alcohol abuse（Marty...Peripheral motor and sensory neuropathies are diseases with different etiologies emerging from genetic disorders,diabetes,infection or inflammation,paraneoplastic damage or intoxications including alcohol abuse（Martyn and Hughes,1997）.展开更多
基金supported by Deutsche Forschungsgemeinschaft(DFG grant EL125/6-1)
文摘Functionality of adult peripheral nerves essentially relies on differentiation of Schwann cells during post- natal development, as well as fine-tuned re- and transdifferentiation in response to peripheral nerve injury. Epigenetic histone modifications play a major role during the differentiation of embryonic stem cells and diverse organ specific progenitor cells, yet only little is known about the epigenetic regulation of Schwa nn cells. Just recently, Fuhrmann et al. reported how the transcription factor Myc-interacting zinc-finger protein 1 （Mizl） might contribute to Schwann cell differentiation through repression of the histone de- methylase Kdm8. Here, we discuss the potential novel role of Mizl in Schwann cell differentiation and give a short overview about previously reported histone modifications underlying peripheral nerve develop- ment and response to injury.
基金supported by Deutsche Forschungsgemeinschaft(DFG grant EL125/6-1)
文摘Peripheral motor and sensory neuropathies are diseases with different etiologies emerging from genetic disorders,diabetes,infection or inflammation,paraneoplastic damage or intoxications including alcohol abuse（Martyn and Hughes,1997）.
