To compare the efficacy and safety of CO_(2)laser plus 5-aminolevulinic acid(ALA)photodynamic therapy(PDT)with CO_(2)laser for the treatment of multiple condyloma acuminatum(CA),120 patients with multiple CA were allo...To compare the efficacy and safety of CO_(2)laser plus 5-aminolevulinic acid(ALA)photodynamic therapy(PDT)with CO_(2)laser for the treatment of multiple condyloma acuminatum(CA),120 patients with multiple CA were allocated into two groups—combined group(CO_(2)laser plus ALA-PDT,n=60)and CO_(2)laser group(CO_(2)laser plus placebo-PDT,n=60).After CO_(2)laser,a 20%ALA or a placebo solution was applied to the CA area 3 h before illumination with red light(635 nm,100mW/cm^(2),80 J/cm^(2)).The treatment was repeated seven days after the first treatment if the lesions were not completely resolved.The complete response rate,recurrence rate and adverse effects in the two groups were analyzed.After two treatments,the complete response rates in the CO_(2)laser group and combined group were 100%(509/509)and 100%(507/507)in the CA(p>0:05),respectively.The recurrence rates in the CO_(2)laser group and combined group were 44.9%(229/509)and 10.6%(54/507)in the CA(p<0:05),respectively.The adverse effects in CO_(2)laser group was more than that in combined group.The combined group is a more effective treatment for multiple CA compared with CO_(2)laser group.T/S.Style the highlighted text as abstract.展开更多
To the Editor:Dermatofibrosarcoma protuberans(DFSP)is a locally aggressive mesenchymal neoplasm of the skin that can be misdiagnosed as dermatofibroma(DF)because of similar histological characteristics.[1,2,3]In this ...To the Editor:Dermatofibrosarcoma protuberans(DFSP)is a locally aggressive mesenchymal neoplasm of the skin that can be misdiagnosed as dermatofibroma(DF)because of similar histological characteristics.[1,2,3]In this study,non-linear optical(NLO)microscopy was used for imaging unstained histological sections to make a differential diagnosis between DFSP and DF.This study aimed to demonstrate that label-free NLO imaging provides significant advantages over standard hematoxylin-eosin(H&E)staining and allows pathologists to increase the diagnostic accuracy by using a quantifiable methodology.展开更多
Acne inversa/hidradenitis suppurativa is a chronic,recurrent,inflammatory skin disease that affects the pilosebaceous units,causinfollicular occlusion.The etiology and pathogenesis of acne inversa/hidradenitis suppura...Acne inversa/hidradenitis suppurativa is a chronic,recurrent,inflammatory skin disease that affects the pilosebaceous units,causinfollicular occlusion.The etiology and pathogenesis of acne inversa/hidradenitis suppurativa involves internal and external factors such as genetic susceptibility,inflammation and immunity,microorganisms,obesity,and smoking.acne inversa/hidradenitis suppurativa is difficult to treat,and the current aim of treatment is to control the frequency and duration of disease flares and improve the quality of life.Treatment protocols for acne inversa/hidradenitis suppurativa should be selected based on the disease severity grade.Medical treatments include antibiotics,retinoids,biologics,immunosuppressive agents,and antiandrogen agents.Adjuvant treatments include surgery and laser/light therapies.This consensus aims to further standardize the diagnosis and treatment procedures of acne inversa/hidradenitis suppurativa in China to facilitate its diagnosis and treatment.展开更多
基金This research was funded in part by the National Natural Sciences Foundation of China(No.30872272 and No.30872273)by the program for New Century Excellent Talents from Ministry of Education of China(NCET-09-0390).
文摘To compare the efficacy and safety of CO_(2)laser plus 5-aminolevulinic acid(ALA)photodynamic therapy(PDT)with CO_(2)laser for the treatment of multiple condyloma acuminatum(CA),120 patients with multiple CA were allocated into two groups—combined group(CO_(2)laser plus ALA-PDT,n=60)and CO_(2)laser group(CO_(2)laser plus placebo-PDT,n=60).After CO_(2)laser,a 20%ALA or a placebo solution was applied to the CA area 3 h before illumination with red light(635 nm,100mW/cm^(2),80 J/cm^(2)).The treatment was repeated seven days after the first treatment if the lesions were not completely resolved.The complete response rate,recurrence rate and adverse effects in the two groups were analyzed.After two treatments,the complete response rates in the CO_(2)laser group and combined group were 100%(509/509)and 100%(507/507)in the CA(p>0:05),respectively.The recurrence rates in the CO_(2)laser group and combined group were 44.9%(229/509)and 10.6%(54/507)in the CA(p<0:05),respectively.The adverse effects in CO_(2)laser group was more than that in combined group.The combined group is a more effective treatment for multiple CA compared with CO_(2)laser group.T/S.Style the highlighted text as abstract.
基金The project was supported by grants from the Special Funds of the Central Government Guiding Local Science and Technology Development(No.2017L3009)the Changjiang Scholars Program and the University Innovative Research Team(No.IRT_15R10)+2 种基金the National Natural Science Foundation of China(No.81671730)the Program for New Century Excellent Talents in University of Fujian Province(No.YTR01254)the Medical Innovation Project of Fujian Province(No.2015-CX-18)。
文摘To the Editor:Dermatofibrosarcoma protuberans(DFSP)is a locally aggressive mesenchymal neoplasm of the skin that can be misdiagnosed as dermatofibroma(DF)because of similar histological characteristics.[1,2,3]In this study,non-linear optical(NLO)microscopy was used for imaging unstained histological sections to make a differential diagnosis between DFSP and DF.This study aimed to demonstrate that label-free NLO imaging provides significant advantages over standard hematoxylin-eosin(H&E)staining and allows pathologists to increase the diagnostic accuracy by using a quantifiable methodology.
文摘Acne inversa/hidradenitis suppurativa is a chronic,recurrent,inflammatory skin disease that affects the pilosebaceous units,causinfollicular occlusion.The etiology and pathogenesis of acne inversa/hidradenitis suppurativa involves internal and external factors such as genetic susceptibility,inflammation and immunity,microorganisms,obesity,and smoking.acne inversa/hidradenitis suppurativa is difficult to treat,and the current aim of treatment is to control the frequency and duration of disease flares and improve the quality of life.Treatment protocols for acne inversa/hidradenitis suppurativa should be selected based on the disease severity grade.Medical treatments include antibiotics,retinoids,biologics,immunosuppressive agents,and antiandrogen agents.Adjuvant treatments include surgery and laser/light therapies.This consensus aims to further standardize the diagnosis and treatment procedures of acne inversa/hidradenitis suppurativa in China to facilitate its diagnosis and treatment.
