Neoglycoproteins of human serum albumin (HSA) modified with some kind of carbohydrates were synthesized. Their molecular weight and purification were determined by HPSEC and SDS-PAGE, respectively. The binding propert...Neoglycoproteins of human serum albumin (HSA) modified with some kind of carbohydrates were synthesized. Their molecular weight and purification were determined by HPSEC and SDS-PAGE, respectively. The binding properties of these conjugates to hepatic stellate cells (HSCs) were evaluated by confocal fluorescence microscopy. The bioactivity revealed that compound 4a (HSA modified with glucose) showed high binding affinity.展开更多
基金Project supported by the Natural Science Foundation(No.9702110064)of Shanghai.
文摘Neoglycoproteins of human serum albumin (HSA) modified with some kind of carbohydrates were synthesized. Their molecular weight and purification were determined by HPSEC and SDS-PAGE, respectively. The binding properties of these conjugates to hepatic stellate cells (HSCs) were evaluated by confocal fluorescence microscopy. The bioactivity revealed that compound 4a (HSA modified with glucose) showed high binding affinity.
