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Application of Stool-PCR test for diagnosis of Helicobacter pylori infection in children 被引量:5
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作者 Tahereh Falsafi Raha Favaedi +1 位作者 Fatemeh Mahjoub Mehri Najafi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第4期484-488,共5页
AIM:To evaluate the usefulness of stool-PCR test for diagnosis of Helicobacter pylori(H pylori)infection in pediatric populations. METHODS:Based on endoscopic features(including nodular gastritis,erosive duodenitis an... AIM:To evaluate the usefulness of stool-PCR test for diagnosis of Helicobacter pylori(H pylori)infection in pediatric populations. METHODS:Based on endoscopic features(including nodular gastritis,erosive duodenitis and ulcer)and/or a positive rapid urease test(RUT)obtained during endoscopy,28 children from a group of children admitted to the Children's Medical Center of Tehran for persistent upper gastrointestinal problems were selected to compare biopsy-based tests with stoolPCR.Their gastric activity and bacterial density were graded by the updated Sydney system,and their first stool after endoscopy was stored at-70℃.Biopsies were cultured on modified campy-blood agar plates and identified by gram-staining,biochemical tests,and PCR.Two methods of phenol-chloroform and boiling were used for DNA extraction from H pylori isolates. Isolation of DNA from stool was performed using a stool DNA extraction kit(Bioneer Inc,Korea).PCR was performed using primers for detection of vacA,cagA,and 16srRNA genes in both isolates and stool. RESULTS:Sixteen out of 28 child patients(57%) were classified as H pylori positive by biopsy-based tests,of which 11(39%)were also positive by stoolPCR.Sensitivity and specificity of stool-PCR was 62.5% and 92.3%respectively.H pylori was observed in histological sections for 10 out of 11 stool-positivepatients.Association was observed between higher score of H pylori in histology and positivity of stoolPCR.Also association was observed between the more severe form of gastritis and a positive stool-PCR. CONCLUSION:Association between higher score of H pylori in histology and a positive stool-PCR make it a very useful test for detection of H pylori active infection in children.We also suggest that a simple stool-PCR method can be a useful test for detection of H pylori virulence genes in stool. 展开更多
关键词 胃炎 幽门疾病 诊断 临床
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Effect of subconjunctival injection with conbercept as an adjuvant to filtration surgery for open angle glaucoma: a prospective randomized interventional 6-month follow-up study 被引量:3
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作者 Jing Zhang Vikash Vikash +4 位作者 Ping Wang Tian Zheng Dong-Lai Chen Qing Wang Min Ke 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第2期235-240,共6页
AIM: To compare the safety and efficacy of subconjunctival injection with conbercept and 5-fluorouracil(5-FU) for open angle glaucoma(OAG) patients after filtration surgery. METHODS: As a prospective randomized interv... AIM: To compare the safety and efficacy of subconjunctival injection with conbercept and 5-fluorouracil(5-FU) for open angle glaucoma(OAG) patients after filtration surgery. METHODS: As a prospective randomized interventional trial, 36 eyes from 36 patients after OAG surgery were collected and divided randomly into conbercept and 5-FU groups. All patients were subconjunctivally injected with either conbercept(0.2 mL) or 5-FU(0.2 mL) on the 5th day post-operatively. The intraocular pressure(IOP), number of medications used, type of conjunctival bleb, and complications were recorded and analyzed pre-operatively and 1d, 1wk, 1, 3 and 6mo post-injection. RESULTS: There were significant differences in IOP between the conbercept and 5-FU groups 1mo(conbercept group: 12.17±1.04 mm Hg; 5-FU group: 13.50±2.33 mm Hg, t=2.214, P=0.037), 3mo(conbercept group: 13.00±1.88 mm Hg; 5-FU group: 14.50±2.28 mm Hg, t=2.153, P=0.039), and 6mo post-injection(conbercept group: 13.28±2.95 mm Hg; 5-FU group: 15.22±2.49 mm Hg, t=2.140, P=0.040); however, in the number of medications, a prominent difference was not shown between groups on post-injection 6mo(t=1.312, P=0.200). Moreover, there was mild vascularity observed in the conbecept group than the 5-FU group 1d(3a, 3b, 3c: t=8.497, 6.693, 4.515, P=0.000), 1wk(3a, 3b, 3c: t=3.431, 6.408, 3.984, P=0.002, 0.000, 0.000), and 1mo post-injection(3a, 3b, 3c: t=2.466, 2.466, 2.503, P=0.019, 0.019, 0.017). Simultaneously, differences from other indicators between the two groups were not demonstrated. Also, there was a lower probability of corneal epithelial stripping in the conbercept group than the 5-FU group(χ2=4.500, P=0.034). CONCLUSION: Subconjunctival injection of conbercept has a safe, effective, and tolerable profile for open angle glaucoma patients with distinct conjunctival congestion after filtration surgery. 展开更多
关键词 filtration surgery conbercept 5-FLUOROURACIL open angle GLAUCOMA
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Endoscopic management of a new entity-plastobezoar:A case report and review of literature 被引量:1
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作者 SP Misra Manisha Dwivedi Vatsala Misra 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第41期6730-6733,共4页
Foreign bodies and bezoars are commonly encountered in children. We describe a child aged 11 years who ingested large amounts of plastic material used for knitting chairs and charpoys. The conglomerate of plastic thre... Foreign bodies and bezoars are commonly encountered in children. We describe a child aged 11 years who ingested large amounts of plastic material used for knitting chairs and charpoys. The conglomerate of plastic threads, entrapped food material and other debris, formed a huge mass occupying the whole stomach. Chronic irritation of the gastric antral mucosa led to ulceration and formation of hyperplastic polyps. We labeled this new entity as a “plastobezoar”. The entire bezoar could be removed endoscopically. 展开更多
关键词 内窥镜 病理 治疗 临床 胃疾病
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Contribution of genetics to a new vision in the understanding of inflammatory bowel disease 被引量:1
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作者 AS Pe■a 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第30期4784-4787,共4页
煽动性的肠疾病(IBD ) 例如 Crohn 的疾病(CD ) 和 ulcerative (UC ) ,是胃肠道的长期的煽动性的自体免疫的条件。另外的机关例如眼睛,皮肤和连接,经常被影响, IBD 可以被自体免疫的起源的另外的疾病伴随。没有为 IBD 的发作负责的... 煽动性的肠疾病(IBD ) 例如 Crohn 的疾病(CD ) 和 ulcerative (UC ) ,是胃肠道的长期的煽动性的自体免疫的条件。另外的机关例如眼睛,皮肤和连接,经常被影响, IBD 可以被自体免疫的起源的另外的疾病伴随。没有为 IBD 的发作负责的单个病因学的因素。在遗传并且在这些基因编码的蛋白质的分子的机制的最近的进展在理解这些复杂疾病产生了新视觉。影响抗原表示并且由先天免疫处理房间的特定的基因的激活可以与主要组织适合性建筑群(MHC ) 的作为结果的激活导致汽车免疫,多重 cytokines 在后天免疫的规定包含。在这评论, IBD 被描述为能最好作为障碍疾病被分类的疾病的一个星座。这视觉,在德国由 Kiel 发展了,包括在我们的环境的变化没由于文明的 westernization 受到天生的免疫系统的改编,并且这产生了自体免疫的疾病的想法。这些疾病影响 1000 个个人的 1-5 并且在不同大陆上在许多国家的国家健康系统上代表主要负担。在世界规模上,主要挑战是产生干预在亚洲,拉丁美洲和非洲阻止这些疾病的发展。 展开更多
关键词 肠炎 遗传学 治疗 病理机制
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Meta-analysis of lymph node metastasis in Siewert type Ⅰ and Ⅱ T1 adenocarcinomas
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作者 Hiroki Osumi Junko Fujisaki +9 位作者 Masami Omae Tomoki Shimizu Toshiyuki Yoshio Akiyoshi Ishiyama Toshiaki Hirasawa Tomohiro Tsuchida Yorimasa Yamamoto Hiroshi Kawachi Noriko Yamamoto Masahiro Igarashi 《World Journal of Meta-Analysis》 2016年第6期118-123,共6页
AIM To evaluate the incidence of lymph node metastasis(LNM) and its risk factors in patients with Siewert type Ⅰ and type Ⅱ pT1 adenocarcinomas.METHODS We enrolled 85 patients [69 men, 16 women; median age(range), 6... AIM To evaluate the incidence of lymph node metastasis(LNM) and its risk factors in patients with Siewert type Ⅰ and type Ⅱ pT1 adenocarcinomas.METHODS We enrolled 85 patients [69 men, 16 women; median age(range), 67(38-84) years] who had undergone esophagectomy or proximal gastrectomy for Siewert type Ⅰ and type Ⅱ pT1 adenocarcinomas. Predictive risk factors of LNM included age, sex, location of the tumor center, confirmed Barrett's esophageal adenocarcinoma, tumor size, macroscopic tumor type, pathology, invasion depth, presence of ulceration, and lymphovascular invasion. Multivariate logistic regression analysis was used to identify factors predicting LNM. We also evaluated the frequencies of LNM for Siewert type Ⅰ and type Ⅱ pT1 adenocarcinomas in meta-data analysis.RESULTS LNMs were found in 11 out of 85 patients(12.9%, 95%CI: 5.8-20.0). Only 1 of the 15 patients(6.6%, 95%CI: 0.0-19.2) who had a final diagnosis of pT1a adenocarcinoma had a positive LNM, whereas 10 ofthe 70 patients(14.2%, 95%CI: 6.0-22.4) with a final diagnosis of pT1b adenocarcinoma had positive LNM. Furthermore, only one of the 30 patients(3.3%, 95%CI: 0.0-9.7) with a tumor invasion depth within 500 μm from muscularis mucosae had positive LNM. Poor differentiation and lymphovascular invasion were independently associated with a risk of LNM. In meta-data analysis, 12 of the 355 patients(3.3%, 95%CI: 1.5-5.2) who had a final diagnosis of pT1a adenocarcinoma had a positive LNM, whereas 91 of the 438 patients(20.7%, 95%CI: 16.9-24.5) with a final diagnosis of pT1b adenocarcinoma had positive LNM. CONCLUSION We consider endoscopic submucosal dissection(ESD) is suitable for patients with Siewert type Ⅰ and type Ⅱ T1 a adenocarcinomas. For patients with T1b adenocarcinoma, especially invasion depth is within 500 μm from muscularis mucosae with no other risk factor for LNM, diagnostic ESD could be a treatment option according to the overall status of patients and the presence of comorbidities. 展开更多
关键词 Siewert type and type adenocarcinomas Lymph node metastasis
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Ileoscopy in patients with ileocolonic tuberculosis 被引量:16
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作者 SP Misra Vatsala Misra Manisha Dwivedi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第11期1723-1727,共5页
AIM: To study the role of retrograde terminal ileoscopy in patients suspected to have ileocolonic tuberculosis. METHODS: A retrospective analysis was performed for patients undergoing colonoscopy for suspected ileocol... AIM: To study the role of retrograde terminal ileoscopy in patients suspected to have ileocolonic tuberculosis. METHODS: A retrospective analysis was performed for patients undergoing colonoscopy for suspected ileocolonic tuberculosis between January 2000 and June 2004, in whom retrograde ileoscopy had been performed. Only patients diagnosed with tuberculosis on the basis of histological findings of either a caseating granuloma or those having non-caseating granuloma or a collection of epithelioid cells at a minimum of one endoscopic lesion (either in the colon or the terminal ileum) on histology with good responses to conventional anti-tuberculous drugs were enrolled for the study. RESULTS: Fifty-three patients were included. The terminal ileum was involved in only 11 patients. Eight of these patients had involvement of the cecum too. Two patients had ileal lesions without cecal involvement; however, lesions were noted in the ascending colon. In one patient the whole colon was normal and only the terminal ileum showed nodularity and ulceration. Histological examination of the ileal biopsies obtained from the ileal lesions showed noncaseating granulomas in five, collection of epithelioid cells in four and nonspecific histology in two patients. Mucosal biopsies obtained from the lesion in the terminal ileum, in the patient in whom mucosal abnormality was observed to be confined to the ileum, showed noncaseating granulomas. In two other patients the ileal biopsies alone showed histological evidence of tuberculosis with biopsies from the colonic lesions showing non-specific inflammatory changes only. CONCLUSION: Retrograde ileoscopy should be performed in all patients undergoing colonoscopy for suspected ileocolonic tuberculosis. In some patients only the terminal ileum may be involved and histological examination may reveal evidence of tuberculosis only from the lesions in the terminal ileum. This approach would lead to additional lesions being picked up andincreasing the chances of well-timed diagnosis of tuberculosis. 展开更多
关键词 回肠结肠性结核病 回肠结肠镜 回肠镜检 回顾性分析
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Clindamycin-induced acute cholestatic hepatitis 被引量:6
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作者 Cem Aygün Orhan Kocaman +2 位作者 Yesim Gürbüz mer Sentürk Sadettin Hülagü 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第40期5408-5410,共3页
我们为牙齿的感染在 clindamycin 的管理以后在一个 42 岁的女人报导尖锐 hepatotoxicity 的一个案例。在治疗的 6 d 以后,她有疲劳,恶心,呕吐,厌食,瘙痒和黄疸。她的实验室分析显示出丙氨酸 aminotransferase (中高音) , 1795 IU... 我们为牙齿的感染在 clindamycin 的管理以后在一个 42 岁的女人报导尖锐 hepatotoxicity 的一个案例。在治疗的 6 d 以后,她有疲劳,恶心,呕吐,厌食,瘙痒和黄疸。她的实验室分析显示出丙氨酸 aminotransferase (中高音) , 1795 IU/L (正常范围 0-40 ) ;aspartate aminotransferase (著名计算机生产厂商) , 1337 IU/L (正常范围 5-34 ) ;硷性磷酸酯酶(高山) , 339 IU/L (正常范围 40-150 ) ;gamma-glutamyl transpeptidase (GGT ) , 148 IU/L (正常范围 9-64 IU/L ) ;全部的胆红素, 4.1 mg/dL;直接胆红素, 2.9 mg/dL 和前凝血酶时间(磅) , 13.5 s 与国际规范的比率(INR ) , 1.04。她被就医,与立即的药中止。她的肝活体检视标本显示出混合类型(肝细胞和胆汁郁积的) 肝的损害,与导致药的肝炎的诊断兼容。用 Naranjo 概率规模的一个客观诱发性评价建议 clindamycin 是尖锐肝炎的可能的原因。在易受影响的个人, clindamycin 使用可以导致尖锐混合类型肝毒性。如果在严重肝损伤被建立以前,这药被中止,完全的恢复可能是可能的。 展开更多
关键词 药物治疗 氯洁霉素 肝损伤 肝炎
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Acute liver injury induced by weight-loss herbal supplements 被引量:5
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作者 Gary C Chen Vivek S Ramanathan +8 位作者 David Law Pauline Funchain George C Chen Samuel French Boris Shlopov Viktor Eysselein David Chung Sonya Reicher Binh V Pham 《World Journal of Hepatology》 CAS 2010年第11期410-415,共6页
We report three cases of patients with acute liver injury induced by weight-loss herbal supplements. One patient took Hydroxycut while the other two took Herbalife supplements. Liver biopsies for all patients dem onst... We report three cases of patients with acute liver injury induced by weight-loss herbal supplements. One patient took Hydroxycut while the other two took Herbalife supplements. Liver biopsies for all patients dem onstrated f indings consistent with drug-induced acute liver injury. To our knowledge, we are the fi rst instit ute to report acute liver injury from both of these two typ es of weight-loss herbal supplements together as a case series. The series emphasizes the importance of taking a cautious approach when consuming herbal supp lements for the purpose of weight loss. 展开更多
关键词 Hydroxycut Herbalife HEPATOTOXICITY HERBAL WEIGHT-LOSS
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Ileocecal masses in patients with amebic liver abscess:Etiology and management 被引量:3
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作者 Sri Prakash Misra Vatsala Misra Marisha Dwivedi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第12期1933-1936,共4页
瞄准:与阿米巴的肝脓肿在病人估计回盲肠质量的原因。方法:有阿米巴的肝脓肿和回盲肠质量的病人被结肠镜检查和活体检视材料的组织学的检查在结肠镜检查期间从损害跟随的提高对比的 CT 扫描小心地检查并且调查。结果:回盲肠群众与阿... 瞄准:与阿米巴的肝脓肿在病人估计回盲肠质量的原因。方法:有阿米巴的肝脓肿和回盲肠质量的病人被结肠镜检查和活体检视材料的组织学的检查在结肠镜检查期间从损害跟随的提高对比的 CT 扫描小心地检查并且调查。结果:回盲肠群众与阿米巴的肝脓肿在十七个病人被发现。团的原因是在 14 个病人,的阿米巴瘤在在 1 个病人的盲肠的 2 个病人和腺癌的盲肠的肺结核。结肠的溃疡在中的五个被注意六(83%) 有在表示的活跃腹泻的病人。在所有这些病人的回盲肠团是阿米巴瘤。溃疡被看见在仅仅之一 11 (9%) 没有腹泻的病人。差别来自有腹泻(P【 0.005 ) 的组是统计上重要的。结论:回盲肠质量不是与阿米巴的肝脓肿的在病人的不平常的发现。尽管,回盲肠团由于在大多数情况中的阿米巴瘤形成,这是在所有病人的案例,这不应该被假定。结肠镜检查和目标活体检视的组织学的检查是强制的避免错过更不祥的损害。 展开更多
关键词 回盲肠疾病 肝脓肿 病因学 治疗方法
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Ileoscopy in 39 hematochezia patients with normal colonoscopy 被引量:2
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作者 SP Misra M Dwivedi V Misra 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第19期3101-3104,共4页
瞄准:估计角色后退在有正常结肠镜检查的便血病人的终端 ileoscopy。方法:在 1997 年 1 月和 2005 年 3 月之间, 39 个便血病人(男性 36,女性 3,意味着年龄 44.7 年) 与报导正常,结肠镜检查经历了重复结肠镜检查。在到达盲肠以后... 瞄准:估计角色后退在有正常结肠镜检查的便血病人的终端 ileoscopy。方法:在 1997 年 1 月和 2005 年 3 月之间, 39 个便血病人(男性 36,女性 3,意味着年龄 44.7 年) 与报导正常,结肠镜检查经历了重复结肠镜检查。在到达盲肠以后,被尝试本地化回盲肠阀门和 intubate 终端回肠。在终端回肠的粘膜的任何反常小心地被记录,活体检视从看似可疑的损害被获得。结果:在学习时期期间,有 39 个病人,为结肠镜检查没在揭示任何反常到盲肠为止的便血招收。全身的结肠镜检查能在所有病人被执行到盲肠为止。终端回肠能在 36 个病人被把管子插进。没有反常在 31 个病人被注意。回肠溃疡在二个病人被注意。与 i 的溃疡一起的 Nodularity 忠实粘膜, Dieulafoy 的损害,和血管瘤的畸形性各在一个病人被注意。从溃疡获得的活体检视的组织学的检查与 nodularity 和溃疡在病人揭示了典型有结节的损害。病人之一有伤寒的溃疡,另外一个有非特定的溃疡。结论:后退终端 ileoscopy 给有限却珍贵的信息,在有便血的病人并且应该在所有被尝试如此的病人。 展开更多
关键词 便血 结肠镜检查 肺结核 内窥镜
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