OBJECTIVE To investigate the clinical characteristics ofmelanosis of the colon (MC) and its correlation with polypus andcarcinoma of the large intestine.METHODS Clinical feature and colonoscopic findings of 156MC pati...OBJECTIVE To investigate the clinical characteristics ofmelanosis of the colon (MC) and its correlation with polypus andcarcinoma of the large intestine.METHODS Clinical feature and colonoscopic findings of 156MC patients were retrospectively analyzed. Final diagnosis of MCcase was made after colonoscopic and pathological examination,and data of the case history was recorded.RESULTS The overall detection rate of MC was 1.12%, with0.46% in males, 0.66% in females. An 82.69% of the patientssuffered various constipations and had a history of takingcathartics. The clinical manifestation of total-colon melanosisoccurred in 83.97% of the patients. There was no significantdifference between the rate of concomitant polypus (27.56%) inthe MC patients and the detection rate of polypus in the patientswho underwent a synchronous colonoscopy (x^2 = 1.205, P = 0.298).Also there was no significant difference between the detectionrate of carcinoma of the large intestine (8.97%) in MC patientsand the detection rate of the same disease in the patients whounderwent synchronous colonoscopy (x^2 = 0.268, P = 0.604). Alogistic regression analysis has shown that the older the age of MCpatients is, the more opportunities of MC and the concomitantpolypus would occur.CONCLUSION MC may be related to constipations and along-term administration of cathartics, among which total-colonmelanosis ranks first in the cases. There is an earlier age of onsetin the females, with a higher detection rate. The older the age ofthe patients is, the higher the detection rate of MC is, and the morepossibility the onset of the concomitant polypus.展开更多
Fever of unknown origin （FUO） was originally defined as a body temperature greater than 38.3℃ on several occasions longer than 3 weeks, with a diagnosis that remains unclear after 7 days of obligatory investigation...Fever of unknown origin （FUO） was originally defined as a body temperature greater than 38.3℃ on several occasions longer than 3 weeks, with a diagnosis that remains unclear after 7 days of obligatory investigation. Only a few types of solid tumors have been associated with FUO. We described 2 patients who had recurrent fever but no other specific gastrointestinal symptoms where carcinoma of the colon was the only identifiable cause. In the first case, a mass arising from the sigmoid colon was found without any nodal metastasis, and the fever was resolved after three days of the surgical resection. In the second case, advanced adenocarcinoma was found in the ascending colon together with liver cirrhosis. Although it was not possible to surgically remove this tumor, prolonged fever in the patient was most likely due to the carcinoma. These cases indicate that clinicians should consider carcinoma of the colon in the differential diagnosis of patients with FUO.展开更多
文摘OBJECTIVE To investigate the clinical characteristics ofmelanosis of the colon (MC) and its correlation with polypus andcarcinoma of the large intestine.METHODS Clinical feature and colonoscopic findings of 156MC patients were retrospectively analyzed. Final diagnosis of MCcase was made after colonoscopic and pathological examination,and data of the case history was recorded.RESULTS The overall detection rate of MC was 1.12%, with0.46% in males, 0.66% in females. An 82.69% of the patientssuffered various constipations and had a history of takingcathartics. The clinical manifestation of total-colon melanosisoccurred in 83.97% of the patients. There was no significantdifference between the rate of concomitant polypus (27.56%) inthe MC patients and the detection rate of polypus in the patientswho underwent a synchronous colonoscopy (x^2 = 1.205, P = 0.298).Also there was no significant difference between the detectionrate of carcinoma of the large intestine (8.97%) in MC patientsand the detection rate of the same disease in the patients whounderwent synchronous colonoscopy (x^2 = 0.268, P = 0.604). Alogistic regression analysis has shown that the older the age of MCpatients is, the more opportunities of MC and the concomitantpolypus would occur.CONCLUSION MC may be related to constipations and along-term administration of cathartics, among which total-colonmelanosis ranks first in the cases. There is an earlier age of onsetin the females, with a higher detection rate. The older the age ofthe patients is, the higher the detection rate of MC is, and the morepossibility the onset of the concomitant polypus.
文摘Fever of unknown origin （FUO） was originally defined as a body temperature greater than 38.3℃ on several occasions longer than 3 weeks, with a diagnosis that remains unclear after 7 days of obligatory investigation. Only a few types of solid tumors have been associated with FUO. We described 2 patients who had recurrent fever but no other specific gastrointestinal symptoms where carcinoma of the colon was the only identifiable cause. In the first case, a mass arising from the sigmoid colon was found without any nodal metastasis, and the fever was resolved after three days of the surgical resection. In the second case, advanced adenocarcinoma was found in the ascending colon together with liver cirrhosis. Although it was not possible to surgically remove this tumor, prolonged fever in the patient was most likely due to the carcinoma. These cases indicate that clinicians should consider carcinoma of the colon in the differential diagnosis of patients with FUO.
