Background It has been reported that lncRNA myosin heavy-chain-associated RNA transcripts(MHRT)can inhibit the apoptosis of cardiomyocytes.It is one of the major pathological changes leading to chronic heart failure.M...Background It has been reported that lncRNA myosin heavy-chain-associated RNA transcripts(MHRT)can inhibit the apoptosis of cardiomyocytes.It is one of the major pathological changes leading to chronic heart failure.Methods The expression level of lncRNA MHRT was assessed by qRT-PCR.Diagnostic values of lncRNA MHRT for chronic heart failure were analyzed by ROC curve analysis.Cell apoptosis was detected by cell apoptosis assay.Results The results demonstrated that expression of lncRNA MHRT in plasma was down-regulated in patients with chronic heart failure compared to that in healthy people.Down-regulation of lncRNA MHRT distinguished chronic heart failure from healthy people.Over-expression of lncRNA MHRT inhibited the apoptosis of human cardiomyocyte cell line AC16 after H2O2 treatment.Follow-up study showed that chronic heart failure patients with lower expression levels of lncRNA MHRT had worse survival conditions compared to patients with higher expression levels of lncRNA MHRT.Conclusion We concluded that circulating lncRNA MHRT might serve as a diagnostic and prognostic marker for chronic heart failure treatment.展开更多
To the Editor:The global pandemic of coronavirus disease 2019(COVID-19)is not under control,and COVID-19 has affected1 tens of millions of people worldwide.Although the main features of COVID-19 are diffuse alveolar d...To the Editor:The global pandemic of coronavirus disease 2019(COVID-19)is not under control,and COVID-19 has affected1 tens of millions of people worldwide.Although the main features of COVID-19 are diffuse alveolar damage and acute respiratory failure,damage to other organs is also of concern because these patients tend to have more severe symptoms and worse prognosis.In this article,we briefly review the characteristics of kidney involvement in COVID-19 and the impact of kidney injury on prognosis of the disease,in order to better understand the COVID-19 epidemic from the perspective of a nephrologist.展开更多
文摘Background It has been reported that lncRNA myosin heavy-chain-associated RNA transcripts(MHRT)can inhibit the apoptosis of cardiomyocytes.It is one of the major pathological changes leading to chronic heart failure.Methods The expression level of lncRNA MHRT was assessed by qRT-PCR.Diagnostic values of lncRNA MHRT for chronic heart failure were analyzed by ROC curve analysis.Cell apoptosis was detected by cell apoptosis assay.Results The results demonstrated that expression of lncRNA MHRT in plasma was down-regulated in patients with chronic heart failure compared to that in healthy people.Down-regulation of lncRNA MHRT distinguished chronic heart failure from healthy people.Over-expression of lncRNA MHRT inhibited the apoptosis of human cardiomyocyte cell line AC16 after H2O2 treatment.Follow-up study showed that chronic heart failure patients with lower expression levels of lncRNA MHRT had worse survival conditions compared to patients with higher expression levels of lncRNA MHRT.Conclusion We concluded that circulating lncRNA MHRT might serve as a diagnostic and prognostic marker for chronic heart failure treatment.
基金the Open Fund of National Clinical Research Center for Geriatric Diseases(No.NCRCC-PLAGH-2018012 and ZXBJ2001)the National Natural Science Foundation of China(Youth program No.81600655)Health Care Program Foundation of PLA General Hospital(Key Project No.NLBJ-2019006).
文摘To the Editor:The global pandemic of coronavirus disease 2019(COVID-19)is not under control,and COVID-19 has affected1 tens of millions of people worldwide.Although the main features of COVID-19 are diffuse alveolar damage and acute respiratory failure,damage to other organs is also of concern because these patients tend to have more severe symptoms and worse prognosis.In this article,we briefly review the characteristics of kidney involvement in COVID-19 and the impact of kidney injury on prognosis of the disease,in order to better understand the COVID-19 epidemic from the perspective of a nephrologist.
