The clinical manifestation of frontal-variant Alzheimer’s disease(fvAD)is not typical,and it is difficult yet necessary to differentiate fvAD from frontal-variant frontal temporal dementia(fvFD).We describe a patient...The clinical manifestation of frontal-variant Alzheimer’s disease(fvAD)is not typical,and it is difficult yet necessary to differentiate fvAD from frontal-variant frontal temporal dementia(fvFD).We describe a patient with early-onset Alzheimer's disease(AD)who presented with an fvFTD-like syndrome and apolipoprotein E ε3/ε4 genotype.A brain amyloid imaging procedure,11 C-Pittsburgh compound B positron emission tomography(PET),supported the final diagnosis of AD.Our present case highlights the clinical variability that characterises early-onset AD.A multimodal approach is crucial when assessing rare forms of dementia.展开更多
基金This study was supported by a grant of Clinical Research Center Project of Shanghai Mental Health Center(CRC2017ZD02)Natural Science Foundation of China(81301139)Western medical guidance project of Shanghai science and Technology Commission(17411970100).
文摘The clinical manifestation of frontal-variant Alzheimer’s disease(fvAD)is not typical,and it is difficult yet necessary to differentiate fvAD from frontal-variant frontal temporal dementia(fvFD).We describe a patient with early-onset Alzheimer's disease(AD)who presented with an fvFTD-like syndrome and apolipoprotein E ε3/ε4 genotype.A brain amyloid imaging procedure,11 C-Pittsburgh compound B positron emission tomography(PET),supported the final diagnosis of AD.Our present case highlights the clinical variability that characterises early-onset AD.A multimodal approach is crucial when assessing rare forms of dementia.
