The pandemic caused by the SARS-CoV-2 coronavirus is still looming worldwide,and the pandemic has challenged health care delivery and health care systems internationally.[1]The epidemic of seasonal influenza would occ...The pandemic caused by the SARS-CoV-2 coronavirus is still looming worldwide,and the pandemic has challenged health care delivery and health care systems internationally.[1]The epidemic of seasonal influenza would occur in the winter months.Since coronavirus disease 2019(COVID-19)and influenza share many clinical symptoms,[2]it is difficult to distinguish these two respiratory infections in the early stage.[3]Although nucleic acid testing was the gold standard to identify different virus infected diseases,false-negative nucleic acid results were reported frequently in COVID-19,[4]and its diagnostic sensitivity is less optimal.Therefore,the aim of our study is to explore and compare the clinical characteristics of COVID-19 and influenza,which could deepen the understanding of these two diseases and provide some guidance for clinicians to make a differential diagnosis.展开更多
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has posed a serious challenge to emergency departments that usually encounter emergencies and severe diseases.[1-5]Angiotensin-converting enzyme 2(ACE2),a pro...Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has posed a serious challenge to emergency departments that usually encounter emergencies and severe diseases.[1-5]Angiotensin-converting enzyme 2(ACE2),a protein that interacts with the viral spike protein(s),allows SARS-CoV-2 to penetrate epithelial cells.[6]There is mounting evidence that suggests that the digestive system may also be affected.[7]An observational study described potential patterns of pancreatic injury(elevated amylase and lipase)in patients with coronavirus disease 2019(COVID-19).[8]Additionally,sporadic case reports have described secondary pancreatitis in patients with SARS-CoV-2 infection and presented imaging evidence.[9]Moreover,a previous study showed that COVID-19 patients not only have a higher risk of developing acute pancreatitis(AP),but also have a significantly higher mortality than those without COVID-19.[10]Using bioinformatics analysis,it may be possible to reveal how COVID-19 and AP are related.In this study,two RNA-seq datasets of SARS-CoV-2 and AP were selected for analysis.展开更多
To the Editor:Sarcopenia is defined as age-related loss of skeletal musclemass and strength,with an incidence of5%to 13%in persons aged>60 years.[1]Sarcopenia is considered a major contributor of frailty in the eld...To the Editor:Sarcopenia is defined as age-related loss of skeletal musclemass and strength,with an incidence of5%to 13%in persons aged>60 years.[1]Sarcopenia is considered a major contributor of frailty in the elderly,and frailty is reported to be associated withpoor outcomes of older people.Sarcopenia can also increase the risk of falls and fractures.展开更多
Chest pain is one of the most common complaints in the emergency department.Diseases of the heart,aorta,lungs,esophagus,stomach,mediastinum,pleura,and abdominal viscera can all cause chest discomfort(Gulati et al.,202...Chest pain is one of the most common complaints in the emergency department.Diseases of the heart,aorta,lungs,esophagus,stomach,mediastinum,pleura,and abdominal viscera can all cause chest discomfort(Gulati et al.,2021;Jiao et al.,2021;Lu et al.,2022).展开更多
基金This research was supported by a grant from the Foundation of Key Discipline Construction of Zhejiang Province for Traditional Chinese Medicine(2017XK-A3)National Key R&D Program of China(2018YFC2001405).
文摘The pandemic caused by the SARS-CoV-2 coronavirus is still looming worldwide,and the pandemic has challenged health care delivery and health care systems internationally.[1]The epidemic of seasonal influenza would occur in the winter months.Since coronavirus disease 2019(COVID-19)and influenza share many clinical symptoms,[2]it is difficult to distinguish these two respiratory infections in the early stage.[3]Although nucleic acid testing was the gold standard to identify different virus infected diseases,false-negative nucleic acid results were reported frequently in COVID-19,[4]and its diagnostic sensitivity is less optimal.Therefore,the aim of our study is to explore and compare the clinical characteristics of COVID-19 and influenza,which could deepen the understanding of these two diseases and provide some guidance for clinicians to make a differential diagnosis.
基金sponsored by the Key Research and Development Program of Zhejiang Province (2019C03076)The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript。
文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has posed a serious challenge to emergency departments that usually encounter emergencies and severe diseases.[1-5]Angiotensin-converting enzyme 2(ACE2),a protein that interacts with the viral spike protein(s),allows SARS-CoV-2 to penetrate epithelial cells.[6]There is mounting evidence that suggests that the digestive system may also be affected.[7]An observational study described potential patterns of pancreatic injury(elevated amylase and lipase)in patients with coronavirus disease 2019(COVID-19).[8]Additionally,sporadic case reports have described secondary pancreatitis in patients with SARS-CoV-2 infection and presented imaging evidence.[9]Moreover,a previous study showed that COVID-19 patients not only have a higher risk of developing acute pancreatitis(AP),but also have a significantly higher mortality than those without COVID-19.[10]Using bioinformatics analysis,it may be possible to reveal how COVID-19 and AP are related.In this study,two RNA-seq datasets of SARS-CoV-2 and AP were selected for analysis.
基金supported by the National Key Research and Development Program(No.2018YFC2000301)Key Research&Development Program of Zhejiang(No.2022C03161)
文摘To the Editor:Sarcopenia is defined as age-related loss of skeletal musclemass and strength,with an incidence of5%to 13%in persons aged>60 years.[1]Sarcopenia is considered a major contributor of frailty in the elderly,and frailty is reported to be associated withpoor outcomes of older people.Sarcopenia can also increase the risk of falls and fractures.
基金supported by the Key Research and Development Program of Zhejiang Province(No.2019C03076),China。
文摘Chest pain is one of the most common complaints in the emergency department.Diseases of the heart,aorta,lungs,esophagus,stomach,mediastinum,pleura,and abdominal viscera can all cause chest discomfort(Gulati et al.,2021;Jiao et al.,2021;Lu et al.,2022).
