Dear Editor,Beige adipocytes,which increase energy expenditure by dissipating energy as heat,have gained attention as a therapeutic target for combating obesity.1 Adipocytes express many types of G-protein-coupled rec...Dear Editor,Beige adipocytes,which increase energy expenditure by dissipating energy as heat,have gained attention as a therapeutic target for combating obesity.1 Adipocytes express many types of G-protein-coupled receptors(GPCRs),each of which has a unique preference for the Gs,Gi,Gq,and G12 subfamilies.While the function of Gs-coupledβ-adrenergic receptors in beige adipocyte induction is well established,2 little is known about the function of G12-coupled GPCRs beyond its suppressive roles in white adipocyte maturation.3 In this study,we generated transgenic mice conditionally expressing a G12-coupled designer GPCR using a Cre-loxP system and investigated the potential effects of G12 signaling on adipocyte biology.展开更多
The development of novel drugs to overcome the current global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an important task.Although antiviral age...The development of novel drugs to overcome the current global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an important task.Although antiviral agents have been investigated,one of the important goals of treatment is also to control the biological response to the infection.A series of elegant basic studies have revealed that lysophosphatidylserine(LysoPS)might play important roles in inflammation through three kinds of G protein-coupled receptors[1];LysoPS reportedly suppresses activation of T cells[2]and secretion of inflammatory cytokines from macrophages[3]and promotes phagocytosis of apoptotic cells,including apoptotic neutrophils,by macrophages[4].展开更多
基金This work is supported by JP20J20669(Y.O.),JP21H04791(A.I.),JP21H05113(A.I.),JPJSBP120213501(A.I.)JPJSBP120218801(A.I.),and JP21H05115(T.S.)from The Japan Society for the Promotion of Science(JSPS)JPMJPR1331(A.I.),JPMJFR215T(A.I.),JPMJMS2023(A.I.)from the Japan Science and Technology Agency(JST)+4 种基金JP19gm5910013(A.I.),JP19gm0010004(A.I.and J.A.),JP20am0101095(A.I.),JP22ama121038(A.I.)and JP22zf0127007(A.I.)from the Japan Agency for Medical Research and Development(AMED)Takeda Science Foundation(A.I.)The Uehara Memorial Foundation(A.I.)Tokyo Biochemical Research Foundation(A.I.)and Daiichi Sankyo Foundation of Life Science(A.I.).F.R.was supported by the Italian Ministry of University and Research through the Department of excellence“Faculty of Sciences”of Scuola Normale Superiore.The research leading to these results also received funding from the Italian Association for Cancer Research(AIRC)under My First AIRC Grant(MFAG)2020-ID.24317 project-P.I.Raimondi Francesco.G.S.and R.B.R.were funded by BMBF-funded de.NBI HD-HuB network,number#031A537C.
文摘Dear Editor,Beige adipocytes,which increase energy expenditure by dissipating energy as heat,have gained attention as a therapeutic target for combating obesity.1 Adipocytes express many types of G-protein-coupled receptors(GPCRs),each of which has a unique preference for the Gs,Gi,Gq,and G12 subfamilies.While the function of Gs-coupledβ-adrenergic receptors in beige adipocyte induction is well established,2 little is known about the function of G12-coupled GPCRs beyond its suppressive roles in white adipocyte maturation.3 In this study,we generated transgenic mice conditionally expressing a G12-coupled designer GPCR using a Cre-loxP system and investigated the potential effects of G12 signaling on adipocyte biology.
基金This work was supported by Research Grants in the Natural Sciences from the Mitsubishi Foundation(MK)Leading Advanced Projects for medical innovation(LEAP)from AMED(JA and YY).
文摘The development of novel drugs to overcome the current global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an important task.Although antiviral agents have been investigated,one of the important goals of treatment is also to control the biological response to the infection.A series of elegant basic studies have revealed that lysophosphatidylserine(LysoPS)might play important roles in inflammation through three kinds of G protein-coupled receptors[1];LysoPS reportedly suppresses activation of T cells[2]and secretion of inflammatory cytokines from macrophages[3]and promotes phagocytosis of apoptotic cells,including apoptotic neutrophils,by macrophages[4].
