To the Editor:A 59-year-old Chinese woman was admitted for fatigue and fever for 1 month.She was diagnosed with chronic active Epstein-Barr virus(CAEBV)infection 3 years ago due to intermittent fever and documented Ep...To the Editor:A 59-year-old Chinese woman was admitted for fatigue and fever for 1 month.She was diagnosed with chronic active Epstein-Barr virus(CAEBV)infection 3 years ago due to intermittent fever and documented Epstein-Barr virus positive serology.On physical examination,her spleen,liver,and superficial lymph nodes were not palpable.There was no sign of pulmonary infection.Initial laboratory tests were as follows:white blood cell count 0.92×10^9/L,hemoglobin 66 g/L,platelet count 15×10^9/L.Serum biochemistry:alanine aminotransferase 44 U/L,aspartate transaminoferase 142 U/L,albumin 26.7 g/L,triglyceride 3.02 mmol/L,and lactate dehydrogenase 1166 U/L.Coagulation indexes were as follows:prothrombin time 14.3 s,activated prothromboplastin time 65.9 s,thrombin time 32.2 s,D-dimer 18.35 mg/L,and fibrinogen 0.81 g/L.Serum ferritin level was significantly elevated to as high as 8500 ng/mL and serum soluble interleukin-2 receptor(sIL-2R)was 13,200 U/mL.On admission,her serum EBV-DNA load was 1.99×10^3 copies/mL.Computed tomography did not find any enlarged lymph nodes and the spleen and liver had a normal size.The bone marrow morphology and pathology revealed no sign of lymphoma but slight hemophagocytosis.展开更多
To the Editor:A 29-year-old Chinese woman was admitted for newly diagnosed acute promyelocytic leukemia (APL).Initial laboratory tests were as follows:white blood cell (WBC) count 1.68× 109/L,hemoglobin 47 ...To the Editor:A 29-year-old Chinese woman was admitted for newly diagnosed acute promyelocytic leukemia (APL).Initial laboratory tests were as follows:white blood cell (WBC) count 1.68× 109/L,hemoglobin 47 g/L,platelet count 35x 109/L,and fibrinogen 0.81 g/L.There was no sign of pulmonary infection or serum biochemistry abnormality on admission.She was treated with all-transretinoic acid (ATRA) and arsenic trioxide (ATO) immediately.展开更多
文摘To the Editor:A 59-year-old Chinese woman was admitted for fatigue and fever for 1 month.She was diagnosed with chronic active Epstein-Barr virus(CAEBV)infection 3 years ago due to intermittent fever and documented Epstein-Barr virus positive serology.On physical examination,her spleen,liver,and superficial lymph nodes were not palpable.There was no sign of pulmonary infection.Initial laboratory tests were as follows:white blood cell count 0.92×10^9/L,hemoglobin 66 g/L,platelet count 15×10^9/L.Serum biochemistry:alanine aminotransferase 44 U/L,aspartate transaminoferase 142 U/L,albumin 26.7 g/L,triglyceride 3.02 mmol/L,and lactate dehydrogenase 1166 U/L.Coagulation indexes were as follows:prothrombin time 14.3 s,activated prothromboplastin time 65.9 s,thrombin time 32.2 s,D-dimer 18.35 mg/L,and fibrinogen 0.81 g/L.Serum ferritin level was significantly elevated to as high as 8500 ng/mL and serum soluble interleukin-2 receptor(sIL-2R)was 13,200 U/mL.On admission,her serum EBV-DNA load was 1.99×10^3 copies/mL.Computed tomography did not find any enlarged lymph nodes and the spleen and liver had a normal size.The bone marrow morphology and pathology revealed no sign of lymphoma but slight hemophagocytosis.
文摘To the Editor:A 29-year-old Chinese woman was admitted for newly diagnosed acute promyelocytic leukemia (APL).Initial laboratory tests were as follows:white blood cell (WBC) count 1.68× 109/L,hemoglobin 47 g/L,platelet count 35x 109/L,and fibrinogen 0.81 g/L.There was no sign of pulmonary infection or serum biochemistry abnormality on admission.She was treated with all-transretinoic acid (ATRA) and arsenic trioxide (ATO) immediately.