Effects of Xiaocangping tablets combined with 5-fluorouracil and cisplatin on immunity, tumor markers, angiogenesis and related factors in patients with advanced esophageal cancer

Objective:To explore the effects of Xiaocangping tablets combined with 5-fluorouracil and cisplatin on immunity, tumor markers, angiogenesis and related factors in patients with advanced esophageal cancer.Methods:86 patients with advanced esophageal cancer admitted to our hospital from March 2014 to February 2017 were randomly divided into control group (43 cases) and observation group (43 cases). All the subjects were treated with 5-fluorouracil plus cisplatin, and the observation group was treated with Xiaocangping tablets on this basis. The changes of immune function, tumor markers, angiogenesis and related factors in the two groups were compared and analyzed.Results:After treatment, the levels of CD4+, CD4+/CD8 + in both groups were significantly higher than those before treatment (P<0.05), while the levels of CD8+ were significantly lower than those before treatment (P<0.05), the levels of CD4+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group (P<0.05), while the levels of CD8+ in the observation group was significantly lower than that in the control group (P<0.05);the levels of CA125, CEA and CA19-9 in the two groups were significantly lower than those before treatment (P<0.05), and the levels of CA125, CEA and CA19-9 in the observation group were significantly lower than those in the control group (P<0.05);the levels of VEGF, TGF-β1, MMP-9, NGAL in the two groups were significantly lower than those before treatment (P<0.05), and the levels of VEGF, TGF-β1, MMP-9, NGAL in the observation group were significantly lower than the control group (P<0.05).Conclusions:Chemotherapy combined with fluorouracil + cisplatin chemotherapy for advanced esophageal cancer can effectively improve the immune function of patients, reduce the level of tumor markers, inhibit the proliferation of tumor blood vessels, and have significant anti-cancer effects, which is of positive significance for controlling the development of patients' conditions.

Effect of radical gastrectomy for stress and immune function in patients with cardiac cancer

Objective: To investigate the effects of abdominal and transthoracic surgery on perioperative stress and immune function in patients with cardiac cancer. Methods: 60 patients with cardiac cancer treated in our hospital from May 2016 to October 2017 were collected. According to the different surgical methods, they were divided into the transthoracic group and the abdominal group, with 30 cases in each group. The changes of inflammatory factors, T-lymphocyte subsets, NK cells, immune globulin, and oxidative stress parameters were compared between the two groups before and 7 d after surgery. Result: There were no significant differences in preoperative inflammatory factors, T lymphocyte subsets, NK cells, immunoglobulins, and oxidative stress between the two groups. At 7 d after surgery, COR and CRP levels increased in both groups, but COR and CRP levels in abdominal group were (63.03±5.31) mg/L and (245.15±22.88) ng/L which were lower than those in transthoracic group. The levels of CD4+,CD4+/CD8+and CD8+ and NK were significantly increased in both groups after operation, and CD4+ and CD4+/CD8+ were (34.23±3.42)% and (1.22±0.12), which were higher than those in the transabdominal group. While the number of CD8+ and NK cells in the group was (28.12±2.91)% and (19.11±1.92)% respectively, which were lower than those in the transthoracic group. The levels of IgA, IgG, and IgM were significantly reduced in both groups after operation, and IgA, IgG, and IgM were (2.84±0.27) g/L, (12.11±1.20) g/L, and (1.46±0.15) g/L respectively, which were higher than those in the transabdominal group. MDA levels in both groups were increased, while SOD levels in both groups were decreased. However, the MDA in the abdominal group was (5.27±0.53) mmol/mL wiche were lower than that in the transthoracic group, and the SOD was (80.26±8.06) U/mL which wewe higher than that in the transthoracic group. Conclusion: The radical gastrectomy can reduce inflammatory stress and oxidative stress in patients with cardiac cancer and protect immune function.