The main goal of this work is to demonstrate the suitability of survival analysis for ontogenetic studies. The research material includes retrospective data of the age of the occurrence of ontogenetic events such as b...The main goal of this work is to demonstrate the suitability of survival analysis for ontogenetic studies. The research material includes retrospective data of the age of the occurrence of ontogenetic events such as birth (N = 487), menarche (N = 2016) and menopause (N = 3597). In order to study the time of occurrence of ontogenetic events and to indicate the impact of environmental factors the survival analysis was applied. First, the percentiles of functions established for studied events were calculated. Next, the Kaplan-Meier survival curves were derived. In the last step theinfluence of environmental factors was established and the comparison of groups determined based on the chosen factors was performed. The delivery time shows that 14% of infants were bornpreterm. The risk of preterm delivery increases with the severity of factors disrupting pregnancy (from none to coexisting maternal and fetal risk factors) (;p < 0.001). In the case of menarche percentile positions indicate that the menarche occurs between the 12thand the 14thyear of life as the period in which most girls exceed the puberty threshold. The Cox’s proportional hazard model indicates that the time of menarche occurrence is significantly depended (;p < 0.001) on the place of the mother’s residence and number of children in the family (respectively p < 0.03 and p < 0.001). The time interval established for 50% occurrence of this experience was designated between the 49th and the 52nd years of life. The time of menopause occurrence is significantly depended on both of considered factors: the educational level and smoking cigarettes (, p < 0.001). Survival analysis is suitable for studies of the distribution in time of developmental events. It can be used to indicate the factors which significantly influence the course of development by modifying the duration of developmental stages.展开更多
Background:Mucopolysaccharidosis(MPS)diseases lead to a profound disruption in normal mechanisms of growth and development.This study was undertaken to determine the general growth of children with MPS I and II.Method...Background:Mucopolysaccharidosis(MPS)diseases lead to a profound disruption in normal mechanisms of growth and development.This study was undertaken to determine the general growth of children with MPS I and II.Methods:The anthropometric data of patients with MPS I and II(n=76)were retrospectively analyzed.The growth patterns of these patients were analyzed and then plotted onto Polish reference charts.Longitudinal analyses were performed to estimate age-related changes.Results:At the time of birth,the body length was greater than reference charts for all MPS groups(Hurler syndrome,P=0.006;attenuated MPS II,P=0.011;severe MPS II,P<0.001).The mean z-score values for every MPS group showed that until the 30th month of life,the growth patterns for all patients were similar.Afterwards,these growth patterns start to differ for individual groups.The body height below the 3rd percentile was achieved around the 30th month for boys with Hurler syndrome,between the 4th and 5th year for patients with severe MPS H and between the 7th and 8th year for patients with attenuated MPS H.Conclusions:The growth pattern differs between patients with MPS I and H.It reflects the clinical severity of MPS and may assist in the evaluation of clinical efficacy of available therapies.展开更多
文摘The main goal of this work is to demonstrate the suitability of survival analysis for ontogenetic studies. The research material includes retrospective data of the age of the occurrence of ontogenetic events such as birth (N = 487), menarche (N = 2016) and menopause (N = 3597). In order to study the time of occurrence of ontogenetic events and to indicate the impact of environmental factors the survival analysis was applied. First, the percentiles of functions established for studied events were calculated. Next, the Kaplan-Meier survival curves were derived. In the last step theinfluence of environmental factors was established and the comparison of groups determined based on the chosen factors was performed. The delivery time shows that 14% of infants were bornpreterm. The risk of preterm delivery increases with the severity of factors disrupting pregnancy (from none to coexisting maternal and fetal risk factors) (;p < 0.001). In the case of menarche percentile positions indicate that the menarche occurs between the 12thand the 14thyear of life as the period in which most girls exceed the puberty threshold. The Cox’s proportional hazard model indicates that the time of menarche occurrence is significantly depended (;p < 0.001) on the place of the mother’s residence and number of children in the family (respectively p < 0.03 and p < 0.001). The time interval established for 50% occurrence of this experience was designated between the 49th and the 52nd years of life. The time of menopause occurrence is significantly depended on both of considered factors: the educational level and smoking cigarettes (, p < 0.001). Survival analysis is suitable for studies of the distribution in time of developmental events. It can be used to indicate the factors which significantly influence the course of development by modifying the duration of developmental stages.
文摘Background:Mucopolysaccharidosis(MPS)diseases lead to a profound disruption in normal mechanisms of growth and development.This study was undertaken to determine the general growth of children with MPS I and II.Methods:The anthropometric data of patients with MPS I and II(n=76)were retrospectively analyzed.The growth patterns of these patients were analyzed and then plotted onto Polish reference charts.Longitudinal analyses were performed to estimate age-related changes.Results:At the time of birth,the body length was greater than reference charts for all MPS groups(Hurler syndrome,P=0.006;attenuated MPS II,P=0.011;severe MPS II,P<0.001).The mean z-score values for every MPS group showed that until the 30th month of life,the growth patterns for all patients were similar.Afterwards,these growth patterns start to differ for individual groups.The body height below the 3rd percentile was achieved around the 30th month for boys with Hurler syndrome,between the 4th and 5th year for patients with severe MPS H and between the 7th and 8th year for patients with attenuated MPS H.Conclusions:The growth pattern differs between patients with MPS I and H.It reflects the clinical severity of MPS and may assist in the evaluation of clinical efficacy of available therapies.
