Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease(IBD).Carnosic acid(CA)is a major antioxidant component of rosemary and sage.Herein,we in...Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease(IBD).Carnosic acid(CA)is a major antioxidant component of rosemary and sage.Herein,we investigated the protective effects of dietary CA on dextran sodium sulfate(DSS)-induced colitis mouse model with an emphasis on its impact on the composition and metabolic function of gut microbiota.We found that CA effectively attenuated DSS-stimulated colitis in mice,as evidenced by reduced disease activity index(DAI),and systemic and colonic inflammation.Additionally,CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice.Moreover,Spearman’s correlation coefficient showed a significant correlation between the fecal metabolites and the gut microbiota species.Changes in gut microbiota and the correlated metabolites might partially explain CA’s anti-inflammatory effects against colitis.Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans.展开更多
Smart grid has integrated an increasing number of distributed energy resources to improve the efficiency and flexibility of power generation and consumption as well as the resilience of the power grid.The energy consu...Smart grid has integrated an increasing number of distributed energy resources to improve the efficiency and flexibility of power generation and consumption as well as the resilience of the power grid.The energy consumers on the power grid,e.g.,households,equipped with distributed energy resources can be considered as"microgrids"that both generate and consume electricity.In this paper,we study the energy community discovery problems which identify energy communities for the microgrids to facilitate energy management,e.g.,load balancing,energy sharing and trading on the grid.Specifically,we present efficient algorithms to discover such communities of microgrids considering both their geo-locations and net energy(NE)over any period.Finally,we experimentally validate the performance of the algorithms using both synthetic and real datasets.展开更多
基金supported by Natural Science Foundation of Guangdong basic and applied basic research foundation(2021A1515010965)General project of Basic and applied basic Research in Guangzhou(202102080241)+3 种基金Laboratory opening project of Guangzhou Medical University(PX-1020423)Natural Science Foundation of Guangdong basic and applied basic research foundation([2018]105)Guangdong Provincial Department of Education(S202010570042)Communist Youth League Committee of Guangzhou Medical University(2019A060).
文摘Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease(IBD).Carnosic acid(CA)is a major antioxidant component of rosemary and sage.Herein,we investigated the protective effects of dietary CA on dextran sodium sulfate(DSS)-induced colitis mouse model with an emphasis on its impact on the composition and metabolic function of gut microbiota.We found that CA effectively attenuated DSS-stimulated colitis in mice,as evidenced by reduced disease activity index(DAI),and systemic and colonic inflammation.Additionally,CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice.Moreover,Spearman’s correlation coefficient showed a significant correlation between the fecal metabolites and the gut microbiota species.Changes in gut microbiota and the correlated metabolites might partially explain CA’s anti-inflammatory effects against colitis.Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans.
基金partially supported by the National Science Foundation(NSF)(No.CNS-1745894)the WISER ISFG grant+1 种基金partly sponsored by the Air Force Office of Scientific Research(AFOSR)(No.YIP FA9550-17-1-0240)the Maryland Procurement Office(No.H98230-18-D-0007).
文摘Smart grid has integrated an increasing number of distributed energy resources to improve the efficiency and flexibility of power generation and consumption as well as the resilience of the power grid.The energy consumers on the power grid,e.g.,households,equipped with distributed energy resources can be considered as"microgrids"that both generate and consume electricity.In this paper,we study the energy community discovery problems which identify energy communities for the microgrids to facilitate energy management,e.g.,load balancing,energy sharing and trading on the grid.Specifically,we present efficient algorithms to discover such communities of microgrids considering both their geo-locations and net energy(NE)over any period.Finally,we experimentally validate the performance of the algorithms using both synthetic and real datasets.
