Objective: To observe the effect of Xiaoyu Zhixue tablet (消瘀止血片,XYZXT) on the expression of platelet membrane glycoproteins in patients with hemorrhagic thrombopathy, and to explore its possible mechanism. Method...Objective: To observe the effect of Xiaoyu Zhixue tablet (消瘀止血片,XYZXT) on the expression of platelet membrane glycoproteins in patients with hemorrhagic thrombopathy, and to explore its possible mechanism. Methods: The total of 148 patients with hemorrhagic thrombopathy were randomly divided into two groups, the traditional Chinese medicicne (TCM) group (n=98) treated with XYZXT and the Western medicine (WM) group (n=50) treated with adrenosin, vitamins C, K and P, both for 6 months. The therapeutic effect and the recovery rate of platelet aggregation in the two groups were observed. And platelet membrane glycoprotein (GP) Ⅰb/Ⅸ, GPⅡb/Ⅲa complexes, GPⅠb, GPⅡb, GP Ⅲa and P-selectin were analyzed by flow cytometry in both groups before and after treatment and also in 34 normal healthy subjects. Results: The total effective rate of hemostasis was 89. 8% in TCM group and 54. 0% in the WM group (x2=45.83, P<0.01), and the recovery rate of platelet aggregation was 72.4% and 4.0% respectively (x2=62.06, P<0.01). The fluorescence intensity of GP Ⅰ b/Ⅸ, GPⅡb/Ⅲa complexes, GPⅠb, GPⅢa and P-selectin were lower in both groups before treatment than those in the healthy subjects. Expression of above-mentioned marks was elevated in TCM group after 6 months' therapy, which was insignificantly different as compared with the healthy subjects (P>0.05) and higher than those in the WM group (P<0.05). Conclusion: One of the mechanisms in treating hemorrhagic thrombopathy with XYZXT is that it could regulate the expression of GP Ⅰb/Ⅸ, GPⅡ b/Ⅲa complexes, GPⅠb, GPⅢa and P-selectin at the level of receptor protein.展开更多
Endometrial stromal sarcoma(ESS)is an extremely rare(<10%)malignancy of female reproductive system,(1,2)The diagnosis of ESS is mainly depended on the morphology and immunohistochemistry techniques.On the basis of ...Endometrial stromal sarcoma(ESS)is an extremely rare(<10%)malignancy of female reproductive system,(1,2)The diagnosis of ESS is mainly depended on the morphology and immunohistochemistry techniques.On the basis of mitotic index,it has been classified into two categories:low-and high-grade ESS.The management of ESS includes surgical resection with or without adjuvant therapy.展开更多
Through reading Chinese ancient book Huangdi Nejing,and summarizing and analyzing related literature,the basic pathogenesis of obesity have been found to be the stomach preponderance and spleen weakness,and the imbala...Through reading Chinese ancient book Huangdi Nejing,and summarizing and analyzing related literature,the basic pathogenesis of obesity have been found to be the stomach preponderance and spleen weakness,and the imbalance of ascending and descending.Banxia Xiexin Decoction not only has the functions of relieving heat to inhibit stomach intake,supplementing deficiency to assist spleen transport,regulate the ascending and descending,but also has the effects of improving insulin resistance and regulating glucolipid metabolism.Therefore,it is suggested that Banxia Xiexin Decoction can be used in the treatment of insulin resistant obesity,which provides ideas and methods for its treatment.展开更多
Objective:To investigate the relationship between various Chinese medicine(CM) types and T-cell subsets(CD4^+ and CD8^+) in the colonic mucous membranes of patients with ulcerative colitis(UC).Methods: Fifty UC patien...Objective:To investigate the relationship between various Chinese medicine(CM) types and T-cell subsets(CD4^+ and CD8^+) in the colonic mucous membranes of patients with ulcerative colitis(UC).Methods: Fifty UC patients were enrolled,after differentiation into four types by CM syndromes,i.e.,the internal heat-damp accumulation type(IHDA),the qi-stagnancy with blood stasis type(QSBS),the Pi(脾)-Shen(肾) yang-deficiency type(PSYD) and the yin-blood deficiency type(YBD).From every patient,3-5 pieces of intestina...展开更多
Objective: To study the effect and mechanism of Tianhuang Granule (田黄冲剂, THG) on hydrocephalus in the patients with acute cerebral hemorrhage (ACH) through intracranial pressure (ICP) monitoring, serum matr...Objective: To study the effect and mechanism of Tianhuang Granule (田黄冲剂, THG) on hydrocephalus in the patients with acute cerebral hemorrhage (ACH) through intracranial pressure (ICP) monitoring, serum matrix metalloproteinase-9 (MMP-9) level observation, and National Institutes of Health Stroke Scale (NIHSS) scoring (for nerve function deficit). Methods: Sixty patients with ACH were equally randomized into two groups by lottery, the control group and the THG group; all were treated with conventional therapy, but to the patients in the THG group, THG was given orally in addition for 28 days. Changes of ICP, MMP-9 expression, and NIHSS scores, as well as the degree of cerebral hematoma and hydrocephalus (by cranial CT scanning) in the patients, were estimated and compared. Results: (1) ICP was lowered more significantly in the THG group, showing a significant difference between groups on day 7 (P〈0.05). (2) MMP-9 expression was down-regulated in the THG group more significantly and earlier than that in the control group. (3) The degrees of cerebral hematoma and hydrocephalus in the THG group on day 7 were reduced significantly as compared with those on day 3 (P〈0.05), but in the control group, the day of significant reduction was delayed to day 14, and the degrees on day 7 and day 14 in the two groups were significantly different (P〈0.05 and P〈0.01). (4) NIHSS score was significantly lower in the THG group than that in the control group on day 14 and day 28 (P〈0.05 and P〈0.01). Conclusion: THG can effectively lower ICP, down-regulate MMP-9 expression, promote the absorption of cerebral hematoma and hydrocephalus, and improve the nerve function, showing a clinical effectiveness than conventional therapy.展开更多
Objective: To evaluate the effect and safety of Pingchuan Yiqi Granule (平喘益气颗粒, PYG) in treating bronchial asthma of qi-deficiency cold syndrome type (BS-QDC). Methods: With the randomized, positive agent ...Objective: To evaluate the effect and safety of Pingchuan Yiqi Granule (平喘益气颗粒, PYG) in treating bronchial asthma of qi-deficiency cold syndrome type (BS-QDC). Methods: With the randomized, positive agent parallel controlled design adopted, the 80 subjects enrolled were assigned in the ratio of 3:1 to two groups, the 60 patients in the trial group were treated with PYG and the 20 in the control group treated with Ruyi Dingchuan Pill (如意定喘丸,RDP), with the therapeutic course consisting of 7 days for both groups. The clinical effects, effects on TCM syndrome and the changes of lung function after treatment were observed. Results: The effect of the treatment on asthma in the trial group: clinically controlled rate was 6.67%, markedly effective rate 51.67%, improved rate 33.33% and ineffective rate 8.33%; and the corresponding rates in the control group were 5.00%, 50.00%, 30.00%, and 15.00% respectively. Comparison between the two groups showed insignificant difference (P〉0.05). The effect on TCM syndrome in the treated group: clinically controlled rate was 11.67%, markedly effective rate 58.33%, effective rate 21.67% and ineffective rate 8.33%; and those in the control group were 10.00%, 50.00%, 30.00% and 10.00% respectively, also showing insignificant difference between the two groups (P〉0.05). Lung function test showed that the change on forced expiratory volume in 1 second (FEV1) after treatment in the trial group was of statistical significance (P〈0.05), but no significant difference was shown in the change of peak expiratory flow (PEE P〉0.05); while the changes in the control group were just the opposite, showing insignificance in FEV1 (P〉0.05) but significance in PEF (P〈0.05). Comparison of the therapeutic effect on lung function between the two groups showed no significant difference (P〉0.05). No adverse reaction was found in either group in the course of treatment. Conclusion: PYG used to treat BS-QDC is effective and safe, it's effect is similar to that of RDP.展开更多
Objective: To explore the mechanism of anti-rheumatic effect of the active fraction of Siegesbeckia pubescens (AFSP). Methods: Adjuvant arthritis (AA) model of rat was produced to observe the effect of AFSP on lymphoc...Objective: To explore the mechanism of anti-rheumatic effect of the active fraction of Siegesbeckia pubescens (AFSP). Methods: Adjuvant arthritis (AA) model of rat was produced to observe the effect of AFSP on lymphocyte proliferation, interleukin-1 and -2 (IL-1,-2) activity, pathologic section of ankle joint, and analgesic effect, in model rat. Results: AFSP could reduce the inflammatory pathologic response of ankle joint. It has good analgesic effect, the analgesic rate being 65%. AFSP could also strengthen T-lymphocyte proliferation, promote IL-2 activity and inhibit IL-1 activity. Compared with the control group, the difference was significant (P<0.01). Conclusion: By means of regulating the immune function of organism, AFSP could improve the local pathologic response to antagonize against rheumatism, therefore, it is an effective anti-rheumatism herbal medicine.展开更多
文摘Objective: To observe the effect of Xiaoyu Zhixue tablet (消瘀止血片,XYZXT) on the expression of platelet membrane glycoproteins in patients with hemorrhagic thrombopathy, and to explore its possible mechanism. Methods: The total of 148 patients with hemorrhagic thrombopathy were randomly divided into two groups, the traditional Chinese medicicne (TCM) group (n=98) treated with XYZXT and the Western medicine (WM) group (n=50) treated with adrenosin, vitamins C, K and P, both for 6 months. The therapeutic effect and the recovery rate of platelet aggregation in the two groups were observed. And platelet membrane glycoprotein (GP) Ⅰb/Ⅸ, GPⅡb/Ⅲa complexes, GPⅠb, GPⅡb, GP Ⅲa and P-selectin were analyzed by flow cytometry in both groups before and after treatment and also in 34 normal healthy subjects. Results: The total effective rate of hemostasis was 89. 8% in TCM group and 54. 0% in the WM group (x2=45.83, P<0.01), and the recovery rate of platelet aggregation was 72.4% and 4.0% respectively (x2=62.06, P<0.01). The fluorescence intensity of GP Ⅰ b/Ⅸ, GPⅡb/Ⅲa complexes, GPⅠb, GPⅢa and P-selectin were lower in both groups before treatment than those in the healthy subjects. Expression of above-mentioned marks was elevated in TCM group after 6 months' therapy, which was insignificantly different as compared with the healthy subjects (P>0.05) and higher than those in the WM group (P<0.05). Conclusion: One of the mechanisms in treating hemorrhagic thrombopathy with XYZXT is that it could regulate the expression of GP Ⅰb/Ⅸ, GPⅡ b/Ⅲa complexes, GPⅠb, GPⅢa and P-selectin at the level of receptor protein.
文摘Endometrial stromal sarcoma(ESS)is an extremely rare(<10%)malignancy of female reproductive system,(1,2)The diagnosis of ESS is mainly depended on the morphology and immunohistochemistry techniques.On the basis of mitotic index,it has been classified into two categories:low-and high-grade ESS.The management of ESS includes surgical resection with or without adjuvant therapy.
基金Supported by National Natural Science Foundation of China(81774420)The Fourth Batch of National TCM(Clinical,Basic)Outstanding Talents Training Project of Qihuang Project(GZYYRJF[2017]24)+1 种基金Construction Project of Inheritance Studio of Famous Old Chinese Medicine Experts of NATCM(GZYYRJF[2016]42)Wuhan Health Research Fund(WZ20C11).
文摘Through reading Chinese ancient book Huangdi Nejing,and summarizing and analyzing related literature,the basic pathogenesis of obesity have been found to be the stomach preponderance and spleen weakness,and the imbalance of ascending and descending.Banxia Xiexin Decoction not only has the functions of relieving heat to inhibit stomach intake,supplementing deficiency to assist spleen transport,regulate the ascending and descending,but also has the effects of improving insulin resistance and regulating glucolipid metabolism.Therefore,it is suggested that Banxia Xiexin Decoction can be used in the treatment of insulin resistant obesity,which provides ideas and methods for its treatment.
文摘Objective:To investigate the relationship between various Chinese medicine(CM) types and T-cell subsets(CD4^+ and CD8^+) in the colonic mucous membranes of patients with ulcerative colitis(UC).Methods: Fifty UC patients were enrolled,after differentiation into four types by CM syndromes,i.e.,the internal heat-damp accumulation type(IHDA),the qi-stagnancy with blood stasis type(QSBS),the Pi(脾)-Shen(肾) yang-deficiency type(PSYD) and the yin-blood deficiency type(YBD).From every patient,3-5 pieces of intestina...
基金Supported by the Special Fund for Integrative Chinese and Western Medical Researches of Tianjin City(No.07057)
文摘Objective: To study the effect and mechanism of Tianhuang Granule (田黄冲剂, THG) on hydrocephalus in the patients with acute cerebral hemorrhage (ACH) through intracranial pressure (ICP) monitoring, serum matrix metalloproteinase-9 (MMP-9) level observation, and National Institutes of Health Stroke Scale (NIHSS) scoring (for nerve function deficit). Methods: Sixty patients with ACH were equally randomized into two groups by lottery, the control group and the THG group; all were treated with conventional therapy, but to the patients in the THG group, THG was given orally in addition for 28 days. Changes of ICP, MMP-9 expression, and NIHSS scores, as well as the degree of cerebral hematoma and hydrocephalus (by cranial CT scanning) in the patients, were estimated and compared. Results: (1) ICP was lowered more significantly in the THG group, showing a significant difference between groups on day 7 (P〈0.05). (2) MMP-9 expression was down-regulated in the THG group more significantly and earlier than that in the control group. (3) The degrees of cerebral hematoma and hydrocephalus in the THG group on day 7 were reduced significantly as compared with those on day 3 (P〈0.05), but in the control group, the day of significant reduction was delayed to day 14, and the degrees on day 7 and day 14 in the two groups were significantly different (P〈0.05 and P〈0.01). (4) NIHSS score was significantly lower in the THG group than that in the control group on day 14 and day 28 (P〈0.05 and P〈0.01). Conclusion: THG can effectively lower ICP, down-regulate MMP-9 expression, promote the absorption of cerebral hematoma and hydrocephalus, and improve the nerve function, showing a clinical effectiveness than conventional therapy.
文摘Objective: To evaluate the effect and safety of Pingchuan Yiqi Granule (平喘益气颗粒, PYG) in treating bronchial asthma of qi-deficiency cold syndrome type (BS-QDC). Methods: With the randomized, positive agent parallel controlled design adopted, the 80 subjects enrolled were assigned in the ratio of 3:1 to two groups, the 60 patients in the trial group were treated with PYG and the 20 in the control group treated with Ruyi Dingchuan Pill (如意定喘丸,RDP), with the therapeutic course consisting of 7 days for both groups. The clinical effects, effects on TCM syndrome and the changes of lung function after treatment were observed. Results: The effect of the treatment on asthma in the trial group: clinically controlled rate was 6.67%, markedly effective rate 51.67%, improved rate 33.33% and ineffective rate 8.33%; and the corresponding rates in the control group were 5.00%, 50.00%, 30.00%, and 15.00% respectively. Comparison between the two groups showed insignificant difference (P〉0.05). The effect on TCM syndrome in the treated group: clinically controlled rate was 11.67%, markedly effective rate 58.33%, effective rate 21.67% and ineffective rate 8.33%; and those in the control group were 10.00%, 50.00%, 30.00% and 10.00% respectively, also showing insignificant difference between the two groups (P〉0.05). Lung function test showed that the change on forced expiratory volume in 1 second (FEV1) after treatment in the trial group was of statistical significance (P〈0.05), but no significant difference was shown in the change of peak expiratory flow (PEE P〉0.05); while the changes in the control group were just the opposite, showing insignificance in FEV1 (P〉0.05) but significance in PEF (P〈0.05). Comparison of the therapeutic effect on lung function between the two groups showed no significant difference (P〉0.05). No adverse reaction was found in either group in the course of treatment. Conclusion: PYG used to treat BS-QDC is effective and safe, it's effect is similar to that of RDP.
文摘Objective: To explore the mechanism of anti-rheumatic effect of the active fraction of Siegesbeckia pubescens (AFSP). Methods: Adjuvant arthritis (AA) model of rat was produced to observe the effect of AFSP on lymphocyte proliferation, interleukin-1 and -2 (IL-1,-2) activity, pathologic section of ankle joint, and analgesic effect, in model rat. Results: AFSP could reduce the inflammatory pathologic response of ankle joint. It has good analgesic effect, the analgesic rate being 65%. AFSP could also strengthen T-lymphocyte proliferation, promote IL-2 activity and inhibit IL-1 activity. Compared with the control group, the difference was significant (P<0.01). Conclusion: By means of regulating the immune function of organism, AFSP could improve the local pathologic response to antagonize against rheumatism, therefore, it is an effective anti-rheumatism herbal medicine.