A slight reduction of blood pressure and heart rate can reduce the risk of developing cardiovascular disease. Maintenance of the respiratory rate within the normal range has also being identified as crucial for a heal...A slight reduction of blood pressure and heart rate can reduce the risk of developing cardiovascular disease. Maintenance of the respiratory rate within the normal range has also being identified as crucial for a healthy heart. Use of Indian and western music have been considered among many preventive programmes for long time in order to risk reduction associated with cardio vascular diseases. Therefore the aim of this study is to describe the effect of Indian classical music on systolic and diastolic blood pressure, pulse rate and respiratory rate in asymptomatic individuals aged 45 to 65 years. Methodology: A community based randomized intervention study was conducted in 252 asymptomatic individuals. The study group (n = 127) listened to a music based on Indian classical system (entire track of 22 minutes). The control group (n = 125) was kept silent for a similar time period. Systolic and diastolic blood pressure, pulse rate and respiratory rate of each study participant were monitored before and after the intervention. Results: Statistically significant reduction in systolic blood pressure (8.53 mmHg), diastolic blood pressure (5.8 mmHg), pulse rate (5.16 breaths per minute) and respiratory rate (2.55 per minute) were observed in the study group after listening to the music (p < 0.01). In the control group, changes observed during the period of intervention were not significant (p > 0.05). The reduction was independent of gender, age, education level, practicing a mind relaxation technique and preferred type of music of the participant. Conclusions: Listening to Indian classical music for about 22 minutes significantly reduced systolic and diastolic blood pressure, pulse rate and respiratory rate of asymptomatic individuals. Hence, music may have a potential benefit in cardio vascular disease preventive programmes.展开更多
Introduction: Quality of life associated with coronary artery disease can be affected by number of factors. Even though standard treatment has improved survival of such patients, the quality of life may be less than i...Introduction: Quality of life associated with coronary artery disease can be affected by number of factors. Even though standard treatment has improved survival of such patients, the quality of life may be less than ideal as the disease affects the physical, social, and emotional functioning of such individuals. Therefore improvement of the quality of life of the patients with coronary artery disease is vital. Though music has been identified having a potential benefit in improving quality of life for many years, researches conducted to recognize the effect of music on quality of life were sparse. Therefore the aim of this study was to determine the effect of frequent long term listening to Indian classical music on quality of life in chronic stable angina (SA) patients. Methodology: This single blind randomized clinical trial was conducted for one month. The intervention group of 30 patients listened to a music based on Indian classical system at home twice a day complementary to their regular treatment. The control group of 30 was only on their usual treatment. Both groups were assessed before and after the intervention for the quality of life by the Sinhala version of SF-36 questionnaire. Results: A statistically significant increase of scores for physical function by 16.17展开更多
Introduction: Ischaemic heart disease is the number one cause of deaths in the world. As these patients experience severe distress due to a number of associated reasons, it is important to focus on both physiological ...Introduction: Ischaemic heart disease is the number one cause of deaths in the world. As these patients experience severe distress due to a number of associated reasons, it is important to focus on both physiological and psychological needs of the patients in the management. Beyond the standard medical and surgical treatments, relaxation therapies such as relaxing music have been identified as having impact in reducing morbidity in ischaemic heart disease. Even though several studies have been conducted to find out the impact of music on pain, anxiety, heart rate and stress associated with myocardial ischaemia, it is hard to find literature on the long-term effects of music on ischaemia. Therefore the effort of this study was to determine the long-term effects of Indian classical music on state of ischaemia in stable angina. Methodology: A single blind randomized clinical trial was conducted on 60 patients of 45 to 65 years of age with stable angina. Intervention group (n = 30) listened to a music based on Indian classical system at home twice a day complementary to their regular treatment for a period of one month. Control group (n = 30) was only on their usual treatment. Both groups were assessed before and one month after the study period for state of ischaemia based on exercise ECG results. Results: Significant improvement in state of ischaemia (p 0.05). Conclusion: Systematic, regular listening of music based on Indian classical system significantly improved the severity of the state of ischaemia associated with stable angina. Hence music therapy has a potential benefit in considering for use as complementary to angina treatment in reducing morbidity.展开更多
Complement activation-related pseudoallergy (CARPA) is a frequent side effect of intravenous therapies with nanoparticle-containing drugs and biologicals that are recognized by the immune system as foreign. It is an a...Complement activation-related pseudoallergy (CARPA) is a frequent side effect of intravenous therapies with nanoparticle-containing drugs and biologicals that are recognized by the immune system as foreign. It is an acute infusion reaction dominated by cutaneous and hemodynamic changes, most significantly a cardiopulmonary distress involving major pulmonary hypertension, systemic hypotension and arrhythmias. Because CARPA is unpredictable by conventional allergy tests and it may be life threatening, it can represent a major barrier to the safe therapeutic application of many modern medicines, including liposomal drugs and monoclonal antibodies. This review summarizes and updates the facts and opens questions regarding this phenomenon, with particular focus on its porcine model.展开更多
文摘A slight reduction of blood pressure and heart rate can reduce the risk of developing cardiovascular disease. Maintenance of the respiratory rate within the normal range has also being identified as crucial for a healthy heart. Use of Indian and western music have been considered among many preventive programmes for long time in order to risk reduction associated with cardio vascular diseases. Therefore the aim of this study is to describe the effect of Indian classical music on systolic and diastolic blood pressure, pulse rate and respiratory rate in asymptomatic individuals aged 45 to 65 years. Methodology: A community based randomized intervention study was conducted in 252 asymptomatic individuals. The study group (n = 127) listened to a music based on Indian classical system (entire track of 22 minutes). The control group (n = 125) was kept silent for a similar time period. Systolic and diastolic blood pressure, pulse rate and respiratory rate of each study participant were monitored before and after the intervention. Results: Statistically significant reduction in systolic blood pressure (8.53 mmHg), diastolic blood pressure (5.8 mmHg), pulse rate (5.16 breaths per minute) and respiratory rate (2.55 per minute) were observed in the study group after listening to the music (p < 0.01). In the control group, changes observed during the period of intervention were not significant (p > 0.05). The reduction was independent of gender, age, education level, practicing a mind relaxation technique and preferred type of music of the participant. Conclusions: Listening to Indian classical music for about 22 minutes significantly reduced systolic and diastolic blood pressure, pulse rate and respiratory rate of asymptomatic individuals. Hence, music may have a potential benefit in cardio vascular disease preventive programmes.
文摘Introduction: Quality of life associated with coronary artery disease can be affected by number of factors. Even though standard treatment has improved survival of such patients, the quality of life may be less than ideal as the disease affects the physical, social, and emotional functioning of such individuals. Therefore improvement of the quality of life of the patients with coronary artery disease is vital. Though music has been identified having a potential benefit in improving quality of life for many years, researches conducted to recognize the effect of music on quality of life were sparse. Therefore the aim of this study was to determine the effect of frequent long term listening to Indian classical music on quality of life in chronic stable angina (SA) patients. Methodology: This single blind randomized clinical trial was conducted for one month. The intervention group of 30 patients listened to a music based on Indian classical system at home twice a day complementary to their regular treatment. The control group of 30 was only on their usual treatment. Both groups were assessed before and after the intervention for the quality of life by the Sinhala version of SF-36 questionnaire. Results: A statistically significant increase of scores for physical function by 16.17
文摘Introduction: Ischaemic heart disease is the number one cause of deaths in the world. As these patients experience severe distress due to a number of associated reasons, it is important to focus on both physiological and psychological needs of the patients in the management. Beyond the standard medical and surgical treatments, relaxation therapies such as relaxing music have been identified as having impact in reducing morbidity in ischaemic heart disease. Even though several studies have been conducted to find out the impact of music on pain, anxiety, heart rate and stress associated with myocardial ischaemia, it is hard to find literature on the long-term effects of music on ischaemia. Therefore the effort of this study was to determine the long-term effects of Indian classical music on state of ischaemia in stable angina. Methodology: A single blind randomized clinical trial was conducted on 60 patients of 45 to 65 years of age with stable angina. Intervention group (n = 30) listened to a music based on Indian classical system at home twice a day complementary to their regular treatment for a period of one month. Control group (n = 30) was only on their usual treatment. Both groups were assessed before and one month after the study period for state of ischaemia based on exercise ECG results. Results: Significant improvement in state of ischaemia (p 0.05). Conclusion: Systematic, regular listening of music based on Indian classical system significantly improved the severity of the state of ischaemia associated with stable angina. Hence music therapy has a potential benefit in considering for use as complementary to angina treatment in reducing morbidity.
文摘Complement activation-related pseudoallergy (CARPA) is a frequent side effect of intravenous therapies with nanoparticle-containing drugs and biologicals that are recognized by the immune system as foreign. It is an acute infusion reaction dominated by cutaneous and hemodynamic changes, most significantly a cardiopulmonary distress involving major pulmonary hypertension, systemic hypotension and arrhythmias. Because CARPA is unpredictable by conventional allergy tests and it may be life threatening, it can represent a major barrier to the safe therapeutic application of many modern medicines, including liposomal drugs and monoclonal antibodies. This review summarizes and updates the facts and opens questions regarding this phenomenon, with particular focus on its porcine model.
