Per-and polyfluoroalkyl substances(PFASs)can disrupt lipid metabolism,and changes in cord blood fatty acid composition have been observed in small newborns.Emerging evidence suggests that exposure to PFASs during preg...Per-and polyfluoroalkyl substances(PFASs)can disrupt lipid metabolism,and changes in cord blood fatty acid composition have been observed in small newborns.Emerging evidence suggests that exposure to PFASs during pregnancy is linked to decreased newborn size,although the evidence is not consistent.The modifying effect of fatty acids on the associations of gestational PFAS exposure with newborn size is still unknown.Here we show that the nutritional status of the fetus,as indicated by the level of fatty acids in the cord blood,mitigates the adverse effects of gestational PFAS exposure on the size of the newborn.Our study confirms the adverse developmental effects of PFASs and identifies emerging short-chain PFASs as the primary drivers of reduced newborn size,despite their lower exposure burden compared to legacy PFASs.Additionally,we find the protective role of cord blood fatty acids,suggesting potential strategies for mitigating the detrimental effects of emerging environmental exposures on human health.Our findings provide new evidence of the potential toxicity of emerging PFASs and call for further toxicity evaluations of these pollutants for regulatory purposes.Future studies should consider the complex interaction between exposure and nutrition within the human body,particularly during the first thousand days of life,to promote lifelong health.展开更多
基金National Natural Science Foundation of China(82373586 and 82173484)Anhui Provincial Natural Science Foundation(2308085Y50)+1 种基金Education Department of Anhui Province for Excellent Young Scientist(2022AH030076)Center for Big Data and Population Health of IHM(JKS2022020).
文摘Per-and polyfluoroalkyl substances(PFASs)can disrupt lipid metabolism,and changes in cord blood fatty acid composition have been observed in small newborns.Emerging evidence suggests that exposure to PFASs during pregnancy is linked to decreased newborn size,although the evidence is not consistent.The modifying effect of fatty acids on the associations of gestational PFAS exposure with newborn size is still unknown.Here we show that the nutritional status of the fetus,as indicated by the level of fatty acids in the cord blood,mitigates the adverse effects of gestational PFAS exposure on the size of the newborn.Our study confirms the adverse developmental effects of PFASs and identifies emerging short-chain PFASs as the primary drivers of reduced newborn size,despite their lower exposure burden compared to legacy PFASs.Additionally,we find the protective role of cord blood fatty acids,suggesting potential strategies for mitigating the detrimental effects of emerging environmental exposures on human health.Our findings provide new evidence of the potential toxicity of emerging PFASs and call for further toxicity evaluations of these pollutants for regulatory purposes.Future studies should consider the complex interaction between exposure and nutrition within the human body,particularly during the first thousand days of life,to promote lifelong health.
