Under the travelling wave transformation, Calogero-Degasperis-Focas equation is reduced to an ordinary differential equation. Using a symmetry group of one parameter, this ODE is reduced to a second-order linear inhom...Under the travelling wave transformation, Calogero-Degasperis-Focas equation is reduced to an ordinary differential equation. Using a symmetry group of one parameter, this ODE is reduced to a second-order linear inhomogeneous ODE. Furthermore, we apply the change of the variable and complete discrimination system for polynomial to solve the corresponding integrals and obtained the classification of all single travelling wave solutions to Calogero- Degasperis-Focas equation.展开更多
The primary goal of a phase I clinical trial is to find the maximum tolerable dose of a treatment. In this paper, we propose a new stepwise method based on confidence bound and information incorporation to determine t...The primary goal of a phase I clinical trial is to find the maximum tolerable dose of a treatment. In this paper, we propose a new stepwise method based on confidence bound and information incorporation to determine the maximum tolerable dose among given dose levels. On the one hand, in order to avoid severe even fatal toxicity to occur and reduce the experimental subjects, the new method is executed from the lowest dose level, and then goes on in a stepwise fashion. On the other hand, in order to improve the accuracy of the recommendation, the final recommendation of the maximum tolerable dose is accomplished through the information incorporation of an additional experimental cohort at the same dose level. Furthermore, empirical simulation results show that the new method has some real advantages in comparison with the modified continual reassessment method.展开更多
基金The project supported by Scientific Research and of Education Department of Heilongjiang Province of China under Grant No. 11511008
文摘Under the travelling wave transformation, Calogero-Degasperis-Focas equation is reduced to an ordinary differential equation. Using a symmetry group of one parameter, this ODE is reduced to a second-order linear inhomogeneous ODE. Furthermore, we apply the change of the variable and complete discrimination system for polynomial to solve the corresponding integrals and obtained the classification of all single travelling wave solutions to Calogero- Degasperis-Focas equation.
文摘The primary goal of a phase I clinical trial is to find the maximum tolerable dose of a treatment. In this paper, we propose a new stepwise method based on confidence bound and information incorporation to determine the maximum tolerable dose among given dose levels. On the one hand, in order to avoid severe even fatal toxicity to occur and reduce the experimental subjects, the new method is executed from the lowest dose level, and then goes on in a stepwise fashion. On the other hand, in order to improve the accuracy of the recommendation, the final recommendation of the maximum tolerable dose is accomplished through the information incorporation of an additional experimental cohort at the same dose level. Furthermore, empirical simulation results show that the new method has some real advantages in comparison with the modified continual reassessment method.
