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考虑疗效和安全性及其相关性的最优两阶段设计 被引量:1
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作者 尹环 王维真 张忠占 《北京工业大学学报》 CAS CSCD 北大核心 2019年第12期1269-1276,共8页
在癌症的Ⅱ期临床试验研究中,新药的疗效和安全性的研究尤为重要.考虑到伦理和经费等问题,减少受试人数是试验设计的主要研究目标,通常采用多阶段优化设计达到减小样本量的效果,最流行的是两阶段优化设计.在综合考虑疗效和安全性的基础... 在癌症的Ⅱ期临床试验研究中,新药的疗效和安全性的研究尤为重要.考虑到伦理和经费等问题,减少受试人数是试验设计的主要研究目标,通常采用多阶段优化设计达到减小样本量的效果,最流行的是两阶段优化设计.在综合考虑疗效和安全性的基础上,进一步考虑两者之间的正相关性,提出了相应的精确检验问题,利用条件期望证明了势函数关于疗效率pr和安全率pt的单调不减性质,得出最大一类错误率在两点达到,最小功效在一条线上达到.在此基础上,在严格控制最大一类错误率和最小功效的条件下,以最小化期望样本量为目标,构造出了最优两阶段设计,从而为这类试验的最优设计提供了一个精确方法.另外,由于新检验问题式(2)的备择空间是原检验问题式(1)备择空间的子集,推出原检验问题式(1)的最优两阶段设计也是新检验问题式(2)的两阶段设计. 展开更多
关键词 多项分布 Ⅱ期临床试验 精确检验 条件期望 最大一类错误率 最小功效
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Thin liquid film morphology driven by electro-static field 被引量:1
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作者 E.M.TIAN T.P.SVOBODNY J.D.PHILLIPS 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2011年第8期1039-1046,共8页
The development of stationary patterns on a thin polymer surface subject to an electric field is studied by means of the hexagonal-planform weakly nonlinear stability analysis and numerical simulations. The time evolu... The development of stationary patterns on a thin polymer surface subject to an electric field is studied by means of the hexagonal-planform weakly nonlinear stability analysis and numerical simulations. The time evolution of the interface between the air and the polymer film on the unbounded spatial domain is described by a thin film equation, incorporating the electric driving force and the surface diffusion.The nonlinear interfacial growth includes the amplitude equations and superposition of one-dimensional structures at regular orientations. The pattern selection is driven by the subcritical instability mechanism in which the relative thickness of the polymer film plays a critical role. 展开更多
关键词 thin film pattern formation electrohydrodynamic instability
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HARMONIC OSCILLATORS AT RESONANCE,PERTURBED BY A NON-LINEAR FRICTION FORCE
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作者 Philip KORMAN Yi LI 《Acta Mathematica Scientia》 SCIE CSCD 2014年第4期1025-1028,共4页
This note is an addendum to the results of Lazer and Frederickson [1], and Lazer [4] on periodic oscillations, with linear part at resonance. We show that a small modification of the argument in [4] provides a more ge... This note is an addendum to the results of Lazer and Frederickson [1], and Lazer [4] on periodic oscillations, with linear part at resonance. We show that a small modification of the argument in [4] provides a more general result. It turns out that things are different for the correspouding Dirichlet boundary value problem. 展开更多
关键词 RESONANCE existence of periodic solutions
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Numerical Solutions to the Robin Inverse Problem with Nonnegativity Constraints
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作者 Weifu Fang Fu-Rong Lin 《Journal of Applied Mathematics and Physics》 2022年第6期2015-2025,共11页
We present iterative numerical methods for solving the inverse problem of recovering the nonnegative Robin coefficient from partial boundary measurement of the solution to the Laplace equation. Based on the boundary i... We present iterative numerical methods for solving the inverse problem of recovering the nonnegative Robin coefficient from partial boundary measurement of the solution to the Laplace equation. Based on the boundary integral equation formulation of the problem, nonnegativity constraints in the form of a penalty term are incorporated conveniently into least-squares iteration schemes for solving the inverse problem. Numerical implementation and examples are presented to illustrate the effectiveness of this strategy in improving recovery results. 展开更多
关键词 Robin Inverse Problem Ill-Posed Problem Laplace Equation Boundary Inte-gral Equation Nonnegativity Constraint Penalty Method
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Semantic Segmentation of Sorghum Using Hyperspectral Data Identifies Genetic Associations 被引量:1
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作者 Chenyong Miao Alejandro Pages +3 位作者 Zheng Xu Eric Rodene Jinliang Yang James C.Schnable 《Plant Phenomics》 2020年第1期14-24,共11页
This study describes the evaluation of a range of approaches to semantic segmentation of hyperspectral images of sorghum plants,classifying each pixel as either nonplant or belonging to one of the three organ types(le... This study describes the evaluation of a range of approaches to semantic segmentation of hyperspectral images of sorghum plants,classifying each pixel as either nonplant or belonging to one of the three organ types(leaf,stalk,panicle).While many current methods for segmentation focus on separating plant pixels from background,organ-specific segmentation makes it feasible to measure a wider range of plant properties.Manually scored training data for a set of hyperspectral images collected from a sorghum association population was used to train and evaluate a set of supervised classification models.Many algorithms show acceptable accuracy for this classification task.Algorithms trained on sorghum data are able to accurately classify maize leaves and stalks,but fail to accurately classify maize reproductive organs which are not directly equivalent to sorghum panicles.Trait measurements extracted from semantic segmentation of sorghum organs can be used to identify both genes known to be controlling variation in a previously measured phenotypes(e.g.,panicle size and plant height)as well as identify signals for genes controlling traits not previously quantified in this population(e.g.,stalk/leaf ratio).Organ level semantic segmentation provides opportunities to identify genes controlling variation in a wide range of morphological phenotypes in sorghum,maize,and other related grain crops. 展开更多
关键词 SORGHUM classify ORGANS
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两阶段设计中单比例的精确置信区间构造
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作者 尹环 王维真 《数理统计与管理》 2024年第6期1053-1064,共12页
在Ⅱ期临床试验中药物疗效不确定的情况下,通常要求参与试验的人数尽可能少。二项分布下单比例的估计多使用基于大样本的渐近区间。Ⅱ期临床试验中大样本一般得不到,因此希望给出参数的精确置信区间,即极小覆盖概率不低于1-α。在两阶... 在Ⅱ期临床试验中药物疗效不确定的情况下,通常要求参与试验的人数尽可能少。二项分布下单比例的估计多使用基于大样本的渐近区间。Ⅱ期临床试验中大样本一般得不到,因此希望给出参数的精确置信区间,即极小覆盖概率不低于1-α。在两阶段优化设计背景下,本文将依据Clopper-Pearson区间和反搜索法给出原始样本空间上的一个合理秩函数,并在该秩函数下构造最优的精确单侧置信区间。从在整个参数空间上的覆盖概率图可以看出,该置信区间的置信系数不低于1-α。进一步,以期望区间长度为评价标准,将提出的新区间与两个已知的精确区间进行比较,发现新区间期望长度更短。最后以乳腺癌药物-奥拉帕尼的数据(2018年3月至2020年1月)为例,给出该药物疗效率的最优精确下单侧置信区间。 展开更多
关键词 二项分布 Ⅱ期临床试验 期望区间长度 秩函数 置信系数
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