The following are the responses to the "letter to the editor"("Helicobacter is preserved in yeast vacuoles! Does Koch's postulates confirm it?") authored by Nader Alipour and Nasrin Gaeini that...The following are the responses to the "letter to the editor"("Helicobacter is preserved in yeast vacuoles! Does Koch's postulates confirm it?") authored by Nader Alipour and Nasrin Gaeini that rejected the methods, results, discussions and conclusions summarized in the review article authored by Siavoshi F and Saniee P. In the article, 7 papers, published between 1998 and 2013, were reviewed. The 7 papers had been reviewed and judged very carefully by the assigned expertise of the journals involved, including the reviewers of the World Journal of Gastroenterology(WJG), before publication. In the review article, 121 references were used to verify the methods, results and discussions of these 7 papers. The review article was edited by the trustworthy British editor of the(WJG), and the final version was rechecked and finally accepted by the reviewers of(WJG). None of the reviewers made comments like those in this "letter to the editor", especially the humorous comments, which seem unprofessional and nonscientific. Above all, the authors' comments show a lack of understanding of basic and advanced microbiology, e.g. bacterial endosymbiosis in eukaryotic cells. Accordingly, their comments all through the letter contain misconceptions. The comments are mostly based on personal conclusions, without any scientific support. It would have been beneficial if the letter had been reviewed by the reviewers of the article by Siavoshi and Saniee.展开更多
We are constrained by widespread cancerous diseases to improve treatment methods which save patients and provide better living conditions during and after the treatment period.Because of the complexity of the treatmen...We are constrained by widespread cancerous diseases to improve treatment methods which save patients and provide better living conditions during and after the treatment period.Because of the complexity of the treatment process,mathematical models need to be used in order to have a better understanding of the process.However,deriving an adequate complex model that can capture the disease pattern which could be confirmed by simulations and experiments has its own barriers.In this paper,a new mathematical model is developed concerning immune system effect on cancer.The model is introduced using nonlinear ordinary differential equations.Also,the qualitative behavior of the proposed system is studied in order to examine the extent of the model with respect to the nature of tumor evolution.Thus,number and status of equilibria points in line with the existence of limit cycles are obtained for sub-systems and the whole system.Meanwhile,possible bifurcations are mentioned,and the consequent evolutions are described.It is shown that the model conforms well to natural possibilities,cancer growth or remission.Thus,the model would be fit for further studies for prediction and contemplating treatment method,especially for immune stimulating drugs and immunotherapy.展开更多
文摘The following are the responses to the "letter to the editor"("Helicobacter is preserved in yeast vacuoles! Does Koch's postulates confirm it?") authored by Nader Alipour and Nasrin Gaeini that rejected the methods, results, discussions and conclusions summarized in the review article authored by Siavoshi F and Saniee P. In the article, 7 papers, published between 1998 and 2013, were reviewed. The 7 papers had been reviewed and judged very carefully by the assigned expertise of the journals involved, including the reviewers of the World Journal of Gastroenterology(WJG), before publication. In the review article, 121 references were used to verify the methods, results and discussions of these 7 papers. The review article was edited by the trustworthy British editor of the(WJG), and the final version was rechecked and finally accepted by the reviewers of(WJG). None of the reviewers made comments like those in this "letter to the editor", especially the humorous comments, which seem unprofessional and nonscientific. Above all, the authors' comments show a lack of understanding of basic and advanced microbiology, e.g. bacterial endosymbiosis in eukaryotic cells. Accordingly, their comments all through the letter contain misconceptions. The comments are mostly based on personal conclusions, without any scientific support. It would have been beneficial if the letter had been reviewed by the reviewers of the article by Siavoshi and Saniee.
文摘We are constrained by widespread cancerous diseases to improve treatment methods which save patients and provide better living conditions during and after the treatment period.Because of the complexity of the treatment process,mathematical models need to be used in order to have a better understanding of the process.However,deriving an adequate complex model that can capture the disease pattern which could be confirmed by simulations and experiments has its own barriers.In this paper,a new mathematical model is developed concerning immune system effect on cancer.The model is introduced using nonlinear ordinary differential equations.Also,the qualitative behavior of the proposed system is studied in order to examine the extent of the model with respect to the nature of tumor evolution.Thus,number and status of equilibria points in line with the existence of limit cycles are obtained for sub-systems and the whole system.Meanwhile,possible bifurcations are mentioned,and the consequent evolutions are described.It is shown that the model conforms well to natural possibilities,cancer growth or remission.Thus,the model would be fit for further studies for prediction and contemplating treatment method,especially for immune stimulating drugs and immunotherapy.
