Since chloroquine(CQ)and hydroxychloroquine(HCQ)can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in cultured cells,the repurposing of these antimalarial drugs wa...Since chloroquine(CQ)and hydroxychloroquine(HCQ)can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in cultured cells,the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease(COVID-19).However,despite promising preliminary findings,many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19.Here,we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.展开更多
基金supported by a Young Investigator Grant from the Human Frontier Science Program(HFSPRGY0080/2018)+1 种基金a Vidi grant from the Netherlands Organization for Scientific Research(NWO-ALW VIDI 864.14.001)funding from the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation programme(grant agreement no.862137).
文摘Since chloroquine(CQ)and hydroxychloroquine(HCQ)can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in cultured cells,the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease(COVID-19).However,despite promising preliminary findings,many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19.Here,we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.
