Background:Recent studies suggest that a healthy diet helps to prevent the development of Alzheimer disease(AD).This study aimed to investigate whether spicy food consumption is associated with cognition and cerebrosp...Background:Recent studies suggest that a healthy diet helps to prevent the development of Alzheimer disease(AD).This study aimed to investigate whether spicy food consumption is associated with cognition and cerebrospinal fluid(CSF)biomarkers of AD in the Chinese population.Methods:We enrolled 55 AD patients and 55 age-and gender-matched cognitively normal(CN)subjects in a case-control study,as well as a cohort of 131 participants without subjective cognitive decline(non-AD)in a cross-sectional study.Spicy food consumption was assessed using the Food Frequency Questionnaire(FFQ).Associations of FFQ scores with cognition and CSF biomarkers of AD were analyzed.Results:In the case-control study,spicy food consumption was lower in AD patients than that in CNs(4.0[4.0-8.0]vs.8.0[4.5-10.0],P<0.001);FFQ scores were positively associated with Mini-Mental Status Examination scores in the total sample(r=0.218,P=0.014).In the cross-sectional study,the association between spicy food consumption and cognition levels was verified in non-AD subjects(r=0.264,P=0.0023).Moreover,higher FFQ scores were significantly associated with higherβ-Amyloid(1-42)(Aβ42)levels and lower phospho-tau/Aβ42 and total tau/Aβ42 ratios in the CSF of non-AD subjects(P<0.05).Conclusion:Spicy food consumption is closely related to higher cognition levels and reversed AD biomarkers in the CSF,suggesting that a capsaicin-rich diet might have the potential to modify the cognitive status and cerebral pathologies associated with AD.展开更多
Dear Editor,Alzheimer’s disease(AD)is the most common cause of dementia among the older population,and is characterized by amyloid-beta(Aβ)accumulation,hyperphosphorylation of tau,and finally neurodegeneration in th...Dear Editor,Alzheimer’s disease(AD)is the most common cause of dementia among the older population,and is characterized by amyloid-beta(Aβ)accumulation,hyperphosphorylation of tau,and finally neurodegeneration in the brain[1].Aβ is the major pathological agent in AD,thus currently most efforts in developing therapies for AD target this peptide.The most promising therapy for this disease is immunotherapy.展开更多
Dear Editor,Brain-reactive autoantibodies are thought to play an important role in mediating disorders of the central nervous system(CNS).These antibodies direct the processes underlying several diseases,such as multi...Dear Editor,Brain-reactive autoantibodies are thought to play an important role in mediating disorders of the central nervous system(CNS).These antibodies direct the processes underlying several diseases,such as multiple sclerosis(MS),neuromyelitis optica(NMO),and neuropsychiatric systemic lupus erythematosus[1-3].In infectious diseases of the CNS,the pathogen itself is regarded to play a major role in the pathogenesis[4].展开更多
基金supported by grants from the National Natural Science Foundation of China(NSFC)(Nos.81625007,91749206,and 81600949)。
文摘Background:Recent studies suggest that a healthy diet helps to prevent the development of Alzheimer disease(AD).This study aimed to investigate whether spicy food consumption is associated with cognition and cerebrospinal fluid(CSF)biomarkers of AD in the Chinese population.Methods:We enrolled 55 AD patients and 55 age-and gender-matched cognitively normal(CN)subjects in a case-control study,as well as a cohort of 131 participants without subjective cognitive decline(non-AD)in a cross-sectional study.Spicy food consumption was assessed using the Food Frequency Questionnaire(FFQ).Associations of FFQ scores with cognition and CSF biomarkers of AD were analyzed.Results:In the case-control study,spicy food consumption was lower in AD patients than that in CNs(4.0[4.0-8.0]vs.8.0[4.5-10.0],P<0.001);FFQ scores were positively associated with Mini-Mental Status Examination scores in the total sample(r=0.218,P=0.014).In the cross-sectional study,the association between spicy food consumption and cognition levels was verified in non-AD subjects(r=0.264,P=0.0023).Moreover,higher FFQ scores were significantly associated with higherβ-Amyloid(1-42)(Aβ42)levels and lower phospho-tau/Aβ42 and total tau/Aβ42 ratios in the CSF of non-AD subjects(P<0.05).Conclusion:Spicy food consumption is closely related to higher cognition levels and reversed AD biomarkers in the CSF,suggesting that a capsaicin-rich diet might have the potential to modify the cognitive status and cerebral pathologies associated with AD.
基金This work was supported by the National Natural Science Foundation of China(81701046)Chongqing Science and Technology Commission(cstc2018jcyjAX0664).
文摘Dear Editor,Alzheimer’s disease(AD)is the most common cause of dementia among the older population,and is characterized by amyloid-beta(Aβ)accumulation,hyperphosphorylation of tau,and finally neurodegeneration in the brain[1].Aβ is the major pathological agent in AD,thus currently most efforts in developing therapies for AD target this peptide.The most promising therapy for this disease is immunotherapy.
基金supported by the National Natural Science Foundation of China(81600936 and 81701046)the Natural Science Foundation of Chongqing Municipality,China(cstc2018jcyJAX0511)。
文摘Dear Editor,Brain-reactive autoantibodies are thought to play an important role in mediating disorders of the central nervous system(CNS).These antibodies direct the processes underlying several diseases,such as multiple sclerosis(MS),neuromyelitis optica(NMO),and neuropsychiatric systemic lupus erythematosus[1-3].In infectious diseases of the CNS,the pathogen itself is regarded to play a major role in the pathogenesis[4].
