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Future therapeutic implications of new molecular mechanism of colorectal cancer 被引量:3
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作者 Sen Lu Cheng-You Jia Jian-She Yang 《World Journal of Gastroenterology》 SCIE CAS 2023年第16期2359-2368,共10页
High incidence(10.2%)and mortality(9.2%)rates led to the ranking of colorectal cancer(CRC)as the second most malignant tumor spectrum worldwide in 2020.Treatment strategies are becoming highly dependent on the molecul... High incidence(10.2%)and mortality(9.2%)rates led to the ranking of colorectal cancer(CRC)as the second most malignant tumor spectrum worldwide in 2020.Treatment strategies are becoming highly dependent on the molecular characteristics of CRC.The classical theories accept two models depicting the origin of CRC:The progression of adenoma to cancer and transformation from serrated polyps to cancer.However,the molecular mechanism of CRC development is very complex.For instance,CRCs originating from laterally spreading tumors(LST)do not adhere to any of these models and exhibit extremely serious progression and poor outcomes.In this article,we present another possible pathway involved in CRC development,particularly from LST,with important molecular characteristics,which would facilitate the design of a novel strategy for targeted therapy. 展开更多
关键词 Colorectal cancer Laterally spreading tumors Molecular mechanism Truncated adenomatous polyposis coli mutation Golgi fragmentation Cancerous mechanism
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Effect of COVID-19 on management of type 1 diabetes:Pushing the boundaries of telemedical healthcare
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作者 Ines Bilic Curcic Maja Cigrovski Berkovic +3 位作者 Tomislav Kizivat Silvija Canecki Varzic Robert Smolic Martina Smolic 《World Journal of Diabetes》 SCIE 2021年第6期780-785,共6页
The new coronavirus disease 2019(COVID-19)pandemic posed a great burden on health care systems worldwide and is an enormous and real obstacle in providing needed health care to patients with chronic diseases such as d... The new coronavirus disease 2019(COVID-19)pandemic posed a great burden on health care systems worldwide and is an enormous and real obstacle in providing needed health care to patients with chronic diseases such as diabetes.Parallel to COVID-19,there have been great advances in technology used for management of type 1 diabetes,primarily insulin pumps,sensors,integrated and closed loop systems,ambulatory glucose profile software,and smart phone apps providing necessary essentials for telemedicine implementation right at the beginning of the COVID-19 pandemic.The results of these remote interventions are reassuring in terms of glycemic management and hemoglobin A1c reductions.However,data on long-term outcomes and cost reductions are missing as well as proper technical infrastructure and government health policy support. 展开更多
关键词 Diabetes management TELEMEDICINE COVID-19 Diabetes type 1
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