Proper development of the human placenta is of vital importance for a successful pregnancy,and a series of pregnancy complications are considered originating from dysfunctional placentas.Like other organ system develo...Proper development of the human placenta is of vital importance for a successful pregnancy,and a series of pregnancy complications are considered originating from dysfunctional placentas.Like other organ system development,placentation requires large numbers of co-regulators,while the underlying molecular mechanisms orchestrating the placental formation and function are poorly understood.Although we have made many signs of progress in understanding the placental architectures and developments using mouse models,the species-specific differences impede our progress due to the lack of appropriate model systems.In the past few years,major progress has been made by the establishment of novel in-vitro self-renewing stem cell models,as well as identifying the full picture of the cellular organization of the maternal and fetal interface.Providing the tools for the investigation of placentation and reproductive-related regulation mechanism.In this review,we focus on the detailed progress of the human trophoblast stem cells culturing system,and the cellular and molecular terrain at the maternal-fetal interface,respectively,thus providing new insights into placental development.展开更多
Reciprocal translocation is a chromosomal structural abnormality that arises when two non-homologous chromosomes rearrange and attach with each other, an incidence that occurs in about 1/500to 1/625 newborns (Mackie a...Reciprocal translocation is a chromosomal structural abnormality that arises when two non-homologous chromosomes rearrange and attach with each other, an incidence that occurs in about 1/500to 1/625 newborns (Mackie and Scriven, 2002). This event typically does not lead to any significant loss of genetic material, thus reciprocal translocation carriers do not exhibit any severe展开更多
Antiphospholipid antibody syndrome is an autoimmune disorder that primarily affects reproductive age women and poses significant obstetric complications.Here we review the pathogenesis,diagnosis,obstetric complication...Antiphospholipid antibody syndrome is an autoimmune disorder that primarily affects reproductive age women and poses significant obstetric complications.Here we review the pathogenesis,diagnosis,obstetric complications,and management in women with antiphospholipid antibody syndrome.展开更多
To editor:Antiphospholipid antibody syndrome(APS)is an autoimmune condition characterized by the production of antiphospholipid antibodies(aPL)with clinical features such as vascular thrombosis or obstetric morbidity....To editor:Antiphospholipid antibody syndrome(APS)is an autoimmune condition characterized by the production of antiphospholipid antibodies(aPL)with clinical features such as vascular thrombosis or obstetric morbidity.1 APS is associated with spontaneous abortions and pregnancy loss.Pregnancies resulting in live births may be complicated by fetal growth restriction,uteroplacental insufficiency,preeclampsia,hemolysis elevated liver enzymes,and low platelets(HELLP)syndrome,and preterm birth.展开更多
基金This work was supported in parts by the National Key R&D Program of China(2017YFC1001402 to H.W.,2018YFC1004102 to J.L.)National Natural Science Foundation of China(81490744 to H.W.,31600945 to J.L.and 31701016 to J.W.)+2 种基金Fujian Natural Science Foundation(2017J01071 to J.L.)the Fundamental Research Funds for the Central Universities(20720180041 J.L.)Foundation from Key Laboratory of Reproduction Regulation of NPFPC(2017KF01 to J.L.).The funders had no role in study design,data collection,and analysis,decision to publish,or preparation of the manuscript
文摘Proper development of the human placenta is of vital importance for a successful pregnancy,and a series of pregnancy complications are considered originating from dysfunctional placentas.Like other organ system development,placentation requires large numbers of co-regulators,while the underlying molecular mechanisms orchestrating the placental formation and function are poorly understood.Although we have made many signs of progress in understanding the placental architectures and developments using mouse models,the species-specific differences impede our progress due to the lack of appropriate model systems.In the past few years,major progress has been made by the establishment of novel in-vitro self-renewing stem cell models,as well as identifying the full picture of the cellular organization of the maternal and fetal interface.Providing the tools for the investigation of placentation and reproductive-related regulation mechanism.In this review,we focus on the detailed progress of the human trophoblast stem cells culturing system,and the cellular and molecular terrain at the maternal-fetal interface,respectively,thus providing new insights into placental development.
基金This study was supported by grants from National Natural Science Foundation of China （No. 30872767） and Natural Science Foundation of Zhejiang （No. Y2080158）.
基金supported by the National Natural Science Foundation of China (No. 31522034)Ministry of Science and Technology of China (2016YFC0900103)the National High Technology Research and Development Program Grant (2015AA020407)
文摘Reciprocal translocation is a chromosomal structural abnormality that arises when two non-homologous chromosomes rearrange and attach with each other, an incidence that occurs in about 1/500to 1/625 newborns (Mackie and Scriven, 2002). This event typically does not lead to any significant loss of genetic material, thus reciprocal translocation carriers do not exhibit any severe
文摘Antiphospholipid antibody syndrome is an autoimmune disorder that primarily affects reproductive age women and poses significant obstetric complications.Here we review the pathogenesis,diagnosis,obstetric complications,and management in women with antiphospholipid antibody syndrome.
文摘To editor:Antiphospholipid antibody syndrome(APS)is an autoimmune condition characterized by the production of antiphospholipid antibodies(aPL)with clinical features such as vascular thrombosis or obstetric morbidity.1 APS is associated with spontaneous abortions and pregnancy loss.Pregnancies resulting in live births may be complicated by fetal growth restriction,uteroplacental insufficiency,preeclampsia,hemolysis elevated liver enzymes,and low platelets(HELLP)syndrome,and preterm birth.
