lbuprofen（IBU） and its derivatives are widely used m treating many diseases, such as depression, glome- rulonephritis, fever caused by common cold or influenza, and rheumatoid arthritis. While in clinical trials, IB...lbuprofen（IBU） and its derivatives are widely used m treating many diseases, such as depression, glome- rulonephritis, fever caused by common cold or influenza, and rheumatoid arthritis. While in clinical trials, IBU was found to have many side effects. To weaken and prevent these side effects, a derivative called ibupro- fen-l-acetoxyethyl ester was synthesized in this paper. The maximum concentration（Cmax） in a shorter time was com- pared with IBU at the same dose.展开更多
文摘lbuprofen（IBU） and its derivatives are widely used m treating many diseases, such as depression, glome- rulonephritis, fever caused by common cold or influenza, and rheumatoid arthritis. While in clinical trials, IBU was found to have many side effects. To weaken and prevent these side effects, a derivative called ibupro- fen-l-acetoxyethyl ester was synthesized in this paper. The maximum concentration（Cmax） in a shorter time was com- pared with IBU at the same dose.
