Currently,15 randomized controlled trials(RCTs)have been designed to investigate whether neoadjuvant therapy(NAT)benefits patients with resectable pancreatic adenocarcinoma(R-PA)compared to surgery alone.Five of them ...Currently,15 randomized controlled trials(RCTs)have been designed to investigate whether neoadjuvant therapy(NAT)benefits patients with resectable pancreatic adenocarcinoma(R-PA)compared to surgery alone.Five of them have acquired results so far;however,corresponding conclusions have not been obtained.We speculated that the reason for this phenomenon could be that some prognostic factors had proven to be adverse through upfront surgery curative patterns,but some of them were not regarded as independent baseline characteristics,which is important to obtaining comparability between the NAT and upfront surgery groups.This fact could cause bias and lead to the difference in the outcomes of RCTs.In this review,we collate data about risk factors(such as tumor size,resection margin,and lymph node status)influencing the prognoses of patients with R-PA from five RCTs and discuss the possible reasons for the varying outcomes.展开更多
基金Supported by 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University,No.ZY20173021-3-5Key Research and Development Projects of Sichuan Province,No.2019YFS0042+1 种基金Post-Doctor Research Project,West China Hospital,Sichuan University,No.2020HXBH168Key R&D Project of Science and Technology Department of Sichuan Province,No.2021YFS0107.
文摘Currently,15 randomized controlled trials(RCTs)have been designed to investigate whether neoadjuvant therapy(NAT)benefits patients with resectable pancreatic adenocarcinoma(R-PA)compared to surgery alone.Five of them have acquired results so far;however,corresponding conclusions have not been obtained.We speculated that the reason for this phenomenon could be that some prognostic factors had proven to be adverse through upfront surgery curative patterns,but some of them were not regarded as independent baseline characteristics,which is important to obtaining comparability between the NAT and upfront surgery groups.This fact could cause bias and lead to the difference in the outcomes of RCTs.In this review,we collate data about risk factors(such as tumor size,resection margin,and lymph node status)influencing the prognoses of patients with R-PA from five RCTs and discuss the possible reasons for the varying outcomes.
