BACKGROUND Sclerosing odontogenic carcinoma is a rare primary intraosseous neoplasm that was featured recently as a single entity in the World Health Organization classification of Head and Neck Tumors 2017,with only ...BACKGROUND Sclerosing odontogenic carcinoma is a rare primary intraosseous neoplasm that was featured recently as a single entity in the World Health Organization classification of Head and Neck Tumors 2017,with only 14 cases published to date.The biological characteristics of sclerosing odontogenic carcinoma remain indistinct because of its rarity;however,it appears to be locally aggressive,with no regional or distant metastasis reported to date.CASE SUMMARY We reported a case of sclerosing odontogenic carcinoma of the maxilla in a 62-year-old woman,who presented with an indolent right palatal swelling,which progressively increased in size over 7 years.Right subtotal maxillectomy with surgical margins of approximately 1.5 cm was performed.The patient remained disease free for 4 years following the ablation surgery.Diagnostic workups,treatment,and therapeutic outcomes were discussed.CONCLUSION More cases are needed to further characterize this entity,understand its biological behavior,and justify the treatment protocols.Resection with wide margins of approximately 1.0 to 1.5 cm is proposed,while neck dissection,post-operative radiotherapy,or chemotherapy are deemed unnecessary.展开更多
To investigate the biological behavior and proper management of myoepithelial carcinomas of salivary glands Methods Twenty seven cases of myoepithelial carcinoma of salivary glands were retrospectively studied and...To investigate the biological behavior and proper management of myoepithelial carcinomas of salivary glands Methods Twenty seven cases of myoepithelial carcinoma of salivary glands were retrospectively studied and their detailed clinical and follow up data were presented Results The subjects consisted of 17 men and 10 women aged 16 to 73 years (mean age: 51 years) The parotid gland was the most common site (n=14) of cancer Clinical features included extensive local growth, invasion of the surrounding tissues, infrequent cervical lymph node metastasis but high rates of distant metastasis, frequent/multiple recurrences and poor prognosis Conclusions Myoepithelial carcinomas of the salivary gland should be classified as high grade malignancies Early and radical surgery with close follow up are essential for achieving favorable outcomes Radiotherapy appears to be non sensitive and elective neck dissection is generally unnecessary展开更多
文摘BACKGROUND Sclerosing odontogenic carcinoma is a rare primary intraosseous neoplasm that was featured recently as a single entity in the World Health Organization classification of Head and Neck Tumors 2017,with only 14 cases published to date.The biological characteristics of sclerosing odontogenic carcinoma remain indistinct because of its rarity;however,it appears to be locally aggressive,with no regional or distant metastasis reported to date.CASE SUMMARY We reported a case of sclerosing odontogenic carcinoma of the maxilla in a 62-year-old woman,who presented with an indolent right palatal swelling,which progressively increased in size over 7 years.Right subtotal maxillectomy with surgical margins of approximately 1.5 cm was performed.The patient remained disease free for 4 years following the ablation surgery.Diagnostic workups,treatment,and therapeutic outcomes were discussed.CONCLUSION More cases are needed to further characterize this entity,understand its biological behavior,and justify the treatment protocols.Resection with wide margins of approximately 1.0 to 1.5 cm is proposed,while neck dissection,post-operative radiotherapy,or chemotherapy are deemed unnecessary.
文摘To investigate the biological behavior and proper management of myoepithelial carcinomas of salivary glands Methods Twenty seven cases of myoepithelial carcinoma of salivary glands were retrospectively studied and their detailed clinical and follow up data were presented Results The subjects consisted of 17 men and 10 women aged 16 to 73 years (mean age: 51 years) The parotid gland was the most common site (n=14) of cancer Clinical features included extensive local growth, invasion of the surrounding tissues, infrequent cervical lymph node metastasis but high rates of distant metastasis, frequent/multiple recurrences and poor prognosis Conclusions Myoepithelial carcinomas of the salivary gland should be classified as high grade malignancies Early and radical surgery with close follow up are essential for achieving favorable outcomes Radiotherapy appears to be non sensitive and elective neck dissection is generally unnecessary
