Severe acute respiratory syndrome coronavirus 2(SARSCov-2)is the etiologic agent of the coronavirus disease 19(COVID-19)pandemic.In viral infections like SARS-CoV-2,a robust anti-viral type 1 immune response,including...Severe acute respiratory syndrome coronavirus 2(SARSCov-2)is the etiologic agent of the coronavirus disease 19(COVID-19)pandemic.In viral infections like SARS-CoV-2,a robust anti-viral type 1 immune response,including upregulation of type 1 CD4+T helper cells(Th1),is required for effective viral clearance while minimizing end-organ pathology and collateral tissue damage.展开更多
Alcoholic liver disease(ALD)encompasses a range of conditions resulting from prolonged and excessive alcohol consumption,causing liver damage such as alcoholic fatty liver,inflammation,fibrosis,and cirrhosis.Alcohol c...Alcoholic liver disease(ALD)encompasses a range of conditions resulting from prolonged and excessive alcohol consumption,causing liver damage such as alcoholic fatty liver,inflammation,fibrosis,and cirrhosis.Alcohol consumption contributes to millions of deaths each year.So far,the effective treatments for ALD are limited.To date,the most effective treatment for ALD is still prevention by avoiding excessive alcohol consumption,and only few specialized medicines are in the market for the treatment of patients suffering from ALD.Small molecules targeting various pathways implicated in ALD pathogenesis can potentially be used for effective therapeutics development.In this review,we provide a concise overview of the latest research findings on potential therapeutic targets,specifically emphasizing small-molecule interventions for the treatment and prevention of ALD.展开更多
Heterozygous single nucleotide variants(SNVs)or copynumber variant(CNV)deletions,involving the mesenchymal forkhead box family transcription factor gene,FOXF1,or its distant lung-specific enhancer,are responsible for ...Heterozygous single nucleotide variants(SNVs)or copynumber variant(CNV)deletions,involving the mesenchymal forkhead box family transcription factor gene,FOXF1,or its distant lung-specific enhancer,are responsible for 80%e90%of cases of alveolar capillary dysplasia with misalignment of pulmonary veins(ACDMPV).1 ACDMPV is a lethal lung developmental disorder with severe progressive respiratory failure and persistent pulmonary arterial hypertension(Supplemental Material).Intriguingly,in contrast to point mutations in FOXF1,the ACDMPV-causative CNV deletions arise de novo almost exclusively on the maternal chromosome 16q24.1.展开更多
基金supported by immunophenotyping assessment in a COVID-19 cohort(IMPACC)and has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases,National Institutes of Health,under Contract numbers NO1-Al-25496 and NO1-Al-25482Nancy Chang,Ph.D.Award for Research Excellence,Baylor College of Medicine.
文摘Severe acute respiratory syndrome coronavirus 2(SARSCov-2)is the etiologic agent of the coronavirus disease 19(COVID-19)pandemic.In viral infections like SARS-CoV-2,a robust anti-viral type 1 immune response,including upregulation of type 1 CD4+T helper cells(Th1),is required for effective viral clearance while minimizing end-organ pathology and collateral tissue damage.
基金supported by the National Institute of Diabetes and Digestive and Kidney(R01-DK121970)to Dr.Feng Li.
文摘Alcoholic liver disease(ALD)encompasses a range of conditions resulting from prolonged and excessive alcohol consumption,causing liver damage such as alcoholic fatty liver,inflammation,fibrosis,and cirrhosis.Alcohol consumption contributes to millions of deaths each year.So far,the effective treatments for ALD are limited.To date,the most effective treatment for ALD is still prevention by avoiding excessive alcohol consumption,and only few specialized medicines are in the market for the treatment of patients suffering from ALD.Small molecules targeting various pathways implicated in ALD pathogenesis can potentially be used for effective therapeutics development.In this review,we provide a concise overview of the latest research findings on potential therapeutic targets,specifically emphasizing small-molecule interventions for the treatment and prevention of ALD.
基金This work was supported by the grants awarded by the US National Institutes of Health(NIH),National Heart Lung and Blood Institute(NHLBI)R01HL137203Eunice Kennedy Shriver National Institute of Child Health&Human Development(NICHD)grant R01HD087292 to P.St.
文摘Heterozygous single nucleotide variants(SNVs)or copynumber variant(CNV)deletions,involving the mesenchymal forkhead box family transcription factor gene,FOXF1,or its distant lung-specific enhancer,are responsible for 80%e90%of cases of alveolar capillary dysplasia with misalignment of pulmonary veins(ACDMPV).1 ACDMPV is a lethal lung developmental disorder with severe progressive respiratory failure and persistent pulmonary arterial hypertension(Supplemental Material).Intriguingly,in contrast to point mutations in FOXF1,the ACDMPV-causative CNV deletions arise de novo almost exclusively on the maternal chromosome 16q24.1.
