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Prostate cancer tends to metastasize in the bone-mimicking microenvironment via activating NF-κB signaling 被引量:3
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作者 Haibo Tong Chunlin Zou +4 位作者 Siyuan Qin Jie Meng Evan T.Keller Jian Zhang Yi Lu 《The Journal of Biomedical Research》 CAS CSCD 2018年第5期343-353,共11页
Prostate cancer preferentially metastasizes to the bone. However, the underlying molecular mechanisms are still unclear. To explore the effects of a bone-mimicking microenvironment on PC3 prostate cancer cell growth a... Prostate cancer preferentially metastasizes to the bone. However, the underlying molecular mechanisms are still unclear. To explore the effects of a bone-mimicking microenvironment on PC3 prostate cancer cell growth and metastasis, we used osteoblast differentiation medium(ODM; minimal essential medium alpha supplemented with L-ascorbic acid) to mimic the bone microenvironment. PC3 cells grown in ODM underwent epithelial-mesenchymal transition and showed enhanced colony formation, migration, and invasion abilities compared to the cells grown in normal medium. PC3 cells grown in ODM showed enhanced metastasis when injected in mice. A screening of signaling pathways related to invasion and metastasis revealed that the NF-κB pathway was activated, which could be reversed by Bay 11-7082, a NF-κB pathway inhibitor. These results indicate that the cells in different culture conditions manifested significantly different biological behaviors and the NF-κB pathway is a potential therapeutic target for prostate cancer bone metastasis. 展开更多
关键词 prostate cancer METASTASIS NF-ΚB Bay 11-7082 EMT
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