Immunotherapy for metastatic gastric cancer

This editorial discusses the article written by Chen et al that was published in the latest edition of the World Journal of Gastrointestinal Surgery.The current study found that programmed cell death 1 ligand 1(PD-L1)expression is considered as one of the pan-cancer biomarkers of immune checkpoint inhibitors(ICIs)treatment response.Four molecular subtypes are widely used to guide and evaluate the prognosis and diagnosis and treatment of gastric cancer(GC)patients.Clinical trials of ICI treatment including Nivolumab,Pembrolizumab,Avelumab have been conducted for metastatic GC(mGC).The effects of various single agent ICIs on mGC therapy varied.ICIs combined with chemotherapy can indeed bring survival benefits to patients with mGC.Combining ICIs with chemotherapy can give more patients the chance of surgery in the treatment of GC transformation.However,not all PD-L1 positive patients can benefit from it.It is urgent to find better biomarkers to predict the response of ICIs for more precise clinical treatment.

The Relationship between Depression and Negative Cognitive Bias in Late Pregnancy Women and Its Influencing Factors

Objective:In recent years,psychological problems in pregnant women have become an important public health problem.Depression is a common psychological problem during pregnancy.At present,most studies focus on prenatal depression in pregnant women,and there is a lack of relevant studies on prenatal negative cognition and its relationship with depression.This study aims to examine the relationship between depression and negative cognitive bias in women in late pregnancy and identify the influencing factors.Methods:A total of 829 women in late pregnancy were recruited from a tertiary hospital between April 2023 and October 2023.The survey included the General Information Questionnaire for Women in Late Pregnancy,the Negative Cognitive Processing Bias Scale,and the Edinburgh Postpartum Depression Scale.Descriptive statistics and theχ^(2) test were employed for univariate analysis of depression among these women.Pearson correlation analysis assessed the relationship between depression scores and negative cognitive bias scores.Multiple linear regression analysis,with depression as the dependent variable,was used to identify the influencing factors of depression in late pregnancy.Results:The detection rate of depression was 26.3%.Planned pregnancy emerged as a protective factor against depression in the third trimester(OR=0.481).Conversely,negative life events during pregnancy and negative memory bias were identified as significant risk factors(OR=2.880,1.146).Conclusion:The prevalence of depression in the third trimester is notably high,with pronounced negative memory bias.Healthcare providers should prioritize the mental health of pregnant women,particularly those with deep and repetitive recollections of negative events,by enhancing psychological monitoring and treatment.