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Preparation and Evaluation of Dual Targeting Nanoparticles for Oral Cancer
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作者 WU Shanshan XIONG Fuliang +5 位作者 ZHANG Xueqiong QIU Tong TANG Mingxiu YE Xiaojing CHEN Zhijun ZHOU Gang 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2019年第6期1495-1504,共10页
A dual-receptor targeting delivery system based on acid-cleavage hydrazone bond was developed in the study. The characters of CMCS-hyd-CUR-EGFR-mAb were identified. The in vitro release studies revealed that this drug... A dual-receptor targeting delivery system based on acid-cleavage hydrazone bond was developed in the study. The characters of CMCS-hyd-CUR-EGFR-mAb were identified. The in vitro release studies revealed that this drug delivery system was acid-sensitive, and the self-assembled nanoparticles which were spherical. The in vitro results indicated that the dual-receptor targeting nanoparticles could be faster internalized into the Cal-27 cells via receptor-mediated endocytosis, which exhibited better antitumor activity than the one-receptor nanoparticles. The experimental results clearly reveal that CMCS-hyd-CUR-EGFR mAb provides a novel way for drug delivery in oral cancer treatment. 展开更多
关键词 hydrazone bond dual-receptor targeting SELF-ASSEMBLY NANOPARTICLE
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