The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria.As an excellent candidate to overcome antibiotic resistance,antimicrobial pepti...The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria.As an excellent candidate to overcome antibiotic resistance,antimicrobial peptides(AMPs)that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity.These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action.This comprehensive review provides a broad overview of AMPs from the origin,structural characteristics,mechanisms of action,biological activities to clinical applications.We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.展开更多
Cell death is an essential biological process for physiological growth and development.Three classical forms of cell death—apoptosis,autophagy,and necrosis—display distinct morphological features by activating speci...Cell death is an essential biological process for physiological growth and development.Three classical forms of cell death—apoptosis,autophagy,and necrosis—display distinct morphological features by activating specific signaling pathways.With recent research advances,we have started to appreciate that these cell death processes can cross-talk through interconnecting,even overlapping,signaling pathways,and the final cell fate is the result of the interplay of different cell death programs.This review provides an insight into the independence of and associations among these three types of cell death and explores the significance of cell death under the specific conditions of human diseases,particularly neurodegenerative diseases and cancer.展开更多
基金supported by grants from the National Natural Science Foundation of China (81770176)the special support plan for Zhejiang Province High-Level Talents (2019R52011)。
文摘The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria.As an excellent candidate to overcome antibiotic resistance,antimicrobial peptides(AMPs)that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity.These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action.This comprehensive review provides a broad overview of AMPs from the origin,structural characteristics,mechanisms of action,biological activities to clinical applications.We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.
基金This work was supported by grants from the National Natural Science Foundation of China(Nos.81770176 and 31470071)the New Century 151 Talent Project of Zhejiang Province,the 521 Talent Foundation of Zhejiang Sci-Tech University,and the Open Foundation from Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province(No.ZJZLSYS004)The funders played no role in the study design,data collection and analysis,decision to publish,or preparation of the manuscript.
文摘Cell death is an essential biological process for physiological growth and development.Three classical forms of cell death—apoptosis,autophagy,and necrosis—display distinct morphological features by activating specific signaling pathways.With recent research advances,we have started to appreciate that these cell death processes can cross-talk through interconnecting,even overlapping,signaling pathways,and the final cell fate is the result of the interplay of different cell death programs.This review provides an insight into the independence of and associations among these three types of cell death and explores the significance of cell death under the specific conditions of human diseases,particularly neurodegenerative diseases and cancer.
