A series of structurally novel P-chiral biaryl bisphosphorus ligands L1-L5 (BABIBOPs) are developed, providing high efficiency for the first time in palladium-catalyzed asymmetric hydrogenation of β-aryl and β-alk...A series of structurally novel P-chiral biaryl bisphosphorus ligands L1-L5 (BABIBOPs) are developed, providing high efficiency for the first time in palladium-catalyzed asymmetric hydrogenation of β-aryl and β-alkyl substituted β-keto esters. With the Pd-1.3 (iPr-BABIBOP) catalyst, a series of chiral β-hydroxyl carboxylic esters are formed in excellent enantioselectivities (up to 〉 99% ee) and yields at catalyst loading as low as 0.01 mol%.展开更多
基金The work is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB20000000), CAS (QYZDY-SSW-SLH029), the National Natural Science Foundation of China (Nos. 21432007, 21572246, 21725205) and K C. Wong Education Foundation.
文摘A series of structurally novel P-chiral biaryl bisphosphorus ligands L1-L5 (BABIBOPs) are developed, providing high efficiency for the first time in palladium-catalyzed asymmetric hydrogenation of β-aryl and β-alkyl substituted β-keto esters. With the Pd-1.3 (iPr-BABIBOP) catalyst, a series of chiral β-hydroxyl carboxylic esters are formed in excellent enantioselectivities (up to 〉 99% ee) and yields at catalyst loading as low as 0.01 mol%.