Fused indolizidines and quinolizidines are important skeletons in a variety of natural products and pharmacologically important compounds.A one-pot tan dem route from amide to fused indolizidines and quinolizidines is...Fused indolizidines and quinolizidines are important skeletons in a variety of natural products and pharmacologically important compounds.A one-pot tan dem route from amide to fused indolizidines and quinolizidines is disclosed.This method is con ducted in mild conditions and shows well tolerance of functional groups.It is also easy to be scaled up to gram scale and can be applied smoothly to the total synthesis of alkaloids such as(±)-crispine A,(±)-xylopinine,(±)-desbromoarborescidine A,(±)-harmicine and other bioactive substances.展开更多
The authors regret that an interesting work about amide activation left uncited in the above-titled publication.An corrigendum is given as follows:In 2017,Huang’s group[1]reported an interesting method consisting of ...The authors regret that an interesting work about amide activation left uncited in the above-titled publication.An corrigendum is given as follows:In 2017,Huang’s group[1]reported an interesting method consisting of the amide activation(Tf_(2)0)induced dehydracoupling of halo-genated secondary amides with alkenes and NaBH4 reduction triggered tandem cyclization reaction.It is an efficient strategy to construct substituted pyrrolidine,piperidine,indolizidine,quinolizidine ring systems,and enimino carbocycles.展开更多
基金We are grateful for the financial support from the National Natural Science Foundation of China(No.81973189)Sichuan Outstanding Young Scientific and Tech no logical Talents Project(No.2020JDJQ0054)+2 种基金Sichuan Science and Technology Program(No.19ZDYF0890)Scientific Research Foundation of the Education Department of Sichuan Province(No.18TD0023)Xihua University Talents Project(No.Z202030).
文摘Fused indolizidines and quinolizidines are important skeletons in a variety of natural products and pharmacologically important compounds.A one-pot tan dem route from amide to fused indolizidines and quinolizidines is disclosed.This method is con ducted in mild conditions and shows well tolerance of functional groups.It is also easy to be scaled up to gram scale and can be applied smoothly to the total synthesis of alkaloids such as(±)-crispine A,(±)-xylopinine,(±)-desbromoarborescidine A,(±)-harmicine and other bioactive substances.
文摘The authors regret that an interesting work about amide activation left uncited in the above-titled publication.An corrigendum is given as follows:In 2017,Huang’s group[1]reported an interesting method consisting of the amide activation(Tf_(2)0)induced dehydracoupling of halo-genated secondary amides with alkenes and NaBH4 reduction triggered tandem cyclization reaction.It is an efficient strategy to construct substituted pyrrolidine,piperidine,indolizidine,quinolizidine ring systems,and enimino carbocycles.
