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Creation and anti-cancer potency in HeLa cells of a novel chimeric toxin, HMGNCIDIN, composed of HMGN2 α- helical domain and PE38 KDEL domain Ⅲ 被引量:6
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作者 XIONG Wen-bi HUANG Ning FENG Yun WU Qi WANG Bo-yao 《Chinese Medical Journal》 SCIE CAS CSCD 2008年第1期82-85,共4页
Using targeted toxins is a promising approach for the therapy of cancer and autoimmune diseases, as well as other disorders/The high mobility group chromosomal protein N2 (HMGN2) is one of the most abundant and well... Using targeted toxins is a promising approach for the therapy of cancer and autoimmune diseases, as well as other disorders/The high mobility group chromosomal protein N2 (HMGN2) is one of the most abundant and well-characterized classes of nonhistone nuclear proteins, which seems to function as architectural elements in chromatin.2 Recently our group isolated an antimicrobial polypeptide from human LAK cells and cervical mucus, 展开更多
关键词 HMGN2a-helical domain pseudomonas exotoxin recombinant anti-cancer chimera
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