A nucleotide base pair is the basic unit of RNA structures. Understanding the thermodynamic and kinetic properties of the closing and opening of a base pair is vital for quantitative understanding the biological funct...A nucleotide base pair is the basic unit of RNA structures. Understanding the thermodynamic and kinetic properties of the closing and opening of a base pair is vital for quantitative understanding the biological functions of many RNA molecules. Due to the fast transition rate, it is difficult to directly observe opening and closing of single nucleic acid base pair in experiments. This review will provide a brief summary of the studies about the thermodynamic and kinetic properties of a base pair opening and closing by using molecular dynamic simulation methods.展开更多
We make use of the recent large sample of 17 042 Mg Ⅱ absorption systems from Quider et al. to analyze the evolution of the redshift number density. Regardless of the strength of the absorption line, we find that the...We make use of the recent large sample of 17 042 Mg Ⅱ absorption systems from Quider et al. to analyze the evolution of the redshift number density. Regardless of the strength of the absorption line, we find that the evolution of the redshift number density can be clearly distinguished into three different phases. In the intermediate redshift epoch （0.6 ≤ z ≤ 1.6）, the evolution of the redshift number density is consis- tent with the non-evolution curve, however, the non-evolution curve over-predicts the values of the redshift number density in the early （z ≤ 0.6） and late （z ≥ 1.6） epochs. Based on the invariant cross-section of the absorber, the lack of evolution in the red- shift number density compared to the non-evolution curve implies the galaxy number density does not evolve during the middle epoch. The fiat evolution of the redshift number density tends to correspond to a shallow evolution in the galaxy merger rate during the late epoch, and the steep decrease of the redshift number density might be ascribed to the small mass of halos during the early epoch.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11574234 and 31270761)
文摘A nucleotide base pair is the basic unit of RNA structures. Understanding the thermodynamic and kinetic properties of the closing and opening of a base pair is vital for quantitative understanding the biological functions of many RNA molecules. Due to the fast transition rate, it is difficult to directly observe opening and closing of single nucleic acid base pair in experiments. This review will provide a brief summary of the studies about the thermodynamic and kinetic properties of a base pair opening and closing by using molecular dynamic simulation methods.
基金supported by the National Natural Science Foundation of China (No. 11073007)the Guangzhou technological project (No. 11C62010685)Guangxi Natural Science Foundation (2012jjAA10090)
文摘We make use of the recent large sample of 17 042 Mg Ⅱ absorption systems from Quider et al. to analyze the evolution of the redshift number density. Regardless of the strength of the absorption line, we find that the evolution of the redshift number density can be clearly distinguished into three different phases. In the intermediate redshift epoch （0.6 ≤ z ≤ 1.6）, the evolution of the redshift number density is consis- tent with the non-evolution curve, however, the non-evolution curve over-predicts the values of the redshift number density in the early （z ≤ 0.6） and late （z ≥ 1.6） epochs. Based on the invariant cross-section of the absorber, the lack of evolution in the red- shift number density compared to the non-evolution curve implies the galaxy number density does not evolve during the middle epoch. The fiat evolution of the redshift number density tends to correspond to a shallow evolution in the galaxy merger rate during the late epoch, and the steep decrease of the redshift number density might be ascribed to the small mass of halos during the early epoch.
