Conversion of potato from a tetraploid, heterozygous, vegetatively propagated crop to a diploid F1hybrid, propagated via botanical seed, would constitute a considerable advance for global agriculture,but faces multipl...Conversion of potato from a tetraploid, heterozygous, vegetatively propagated crop to a diploid F1hybrid, propagated via botanical seed, would constitute a considerable advance for global agriculture,but faces multiple challenges. One such challenge is the difficulty in inbreeding potato, which involvespurging deleterious alleles from its genome. This commentary discusses possible reasons for thisdifficulty and highlights a recent sequence-based effort to classify SNP variation, in potato germplasm,according to its deleterious potential. Tools and strategies connected to this database may facilitatedevelopment of F1 hybrids.展开更多
Next-generation sequencing technological advances,affording high-throughput,scalable,and fast assemblies,have enabled genome editing techniques that allow us to remove,insert,and modify genes for rapid and precise fun...Next-generation sequencing technological advances,affording high-throughput,scalable,and fast assemblies,have enabled genome editing techniques that allow us to remove,insert,and modify genes for rapid and precise functional investigations.展开更多
基金supported by the National Science Foundation Plant Genome Integrative Organismal Systems(IOS)Grant 2310230(Characterization of Haploid Induction in Potato)Grant 1956429(Variants and Recombinants without Meiosis).
文摘Conversion of potato from a tetraploid, heterozygous, vegetatively propagated crop to a diploid F1hybrid, propagated via botanical seed, would constitute a considerable advance for global agriculture,but faces multiple challenges. One such challenge is the difficulty in inbreeding potato, which involvespurging deleterious alleles from its genome. This commentary discusses possible reasons for thisdifficulty and highlights a recent sequence-based effort to classify SNP variation, in potato germplasm,according to its deleterious potential. Tools and strategies connected to this database may facilitatedevelopment of F1 hybrids.
基金supported by a Science Foundation Ireland Principal Investigator Grant(13/IAV/1820)to C.S.F.L.is supported by the Irish Research Council Postgraduate Fellowship GOIPG/2018/1960.F.L.and this work were partially funded by Cost Action CA16212“lmpacts of Chromatin Domains on Plant Phenotypes(INDEPTH)”(F.L.,F.P.,and A.V.P.are members of INDEPTH).F.L.was partly supported by EMBO Short Term Fellowship 8312.No conflict of interest is declared.
文摘Next-generation sequencing technological advances,affording high-throughput,scalable,and fast assemblies,have enabled genome editing techniques that allow us to remove,insert,and modify genes for rapid and precise functional investigations.
