The development of interdisciplinary biomedical engineering brings significant breakthroughs to the field of cartilage regeneration.However,cartilage defects are considerably more complicated in clinical conditions,es...The development of interdisciplinary biomedical engineering brings significant breakthroughs to the field of cartilage regeneration.However,cartilage defects are considerably more complicated in clinical conditions,especially when injuries occur at specific sites(e.g.,osteochondral tissue,growth plate,and weight-bearing area)or under inflammatory microenvironments(e.g.,osteoarthritis and rheumatoid arthritis).Therapeutic implantations,including advanced scaffolds,developed growth factors,and various cells alone or in combination currently used to treat cartilage lesions,address cartilage regeneration under abnormal conditions.This review summarizes the strategies for cartilage regeneration at particular sites and pathological microenvironment regulation and discusses the challenges and opportunities for clinical transformation.展开更多
基金financially supported by the National Natural Science Foundation of China(Grant Nos.82102358,82001971,81701811,and 81772456)the Science and Technology Development Program of Jilin Province(Grant Nos.20200802008GH,20200404202YY,20200404190YY,20200404140YY,20200403088SF,20190304123YY,20190201068JC,20180623050TC,and 20180201041SF)+2 种基金the Health Department Program of Jilin Province(Grant Nos.2020Q018,2019SCZT001,2019SCZT014,2019SRCJ001,and 2017F007)the Youth Talents Promotion Project of Jilin Province(Grant No.192004)the Interdisciplinary Research Funding Program for Doctoral Candidates of Jilin University(Grant No.41900200861).
文摘The development of interdisciplinary biomedical engineering brings significant breakthroughs to the field of cartilage regeneration.However,cartilage defects are considerably more complicated in clinical conditions,especially when injuries occur at specific sites(e.g.,osteochondral tissue,growth plate,and weight-bearing area)or under inflammatory microenvironments(e.g.,osteoarthritis and rheumatoid arthritis).Therapeutic implantations,including advanced scaffolds,developed growth factors,and various cells alone or in combination currently used to treat cartilage lesions,address cartilage regeneration under abnormal conditions.This review summarizes the strategies for cartilage regeneration at particular sites and pathological microenvironment regulation and discusses the challenges and opportunities for clinical transformation.
