Osteosarcoma (OS) is the most common histological form of primary bone cancer in childhood cancer and young adults. At present, OS is widely investigated because of the interaction between the tumor and bone microenvi...Osteosarcoma (OS) is the most common histological form of primary bone cancer in childhood cancer and young adults. At present, OS is widely investigated because of the interaction between the tumor and bone microenvironment and the effect of such interaction on OS progression and metastasis.1 The connective tissue growth factor (CTGF), also known as cellular communication network factor 2 (CCN2), is a secreted extracellular matrix-associated protein. CTGF is as active as the regulators of signaling activities of several different pathways and an orchestrator of their cross-talk.2 Therefore, we conducted experiments to investigate the effects of CTGF on OS tumor progress and the cross-talk with stromal cells in the tumor microenvironment.展开更多
The flow-through hybridization and gene chip(FHGC)was developed to used in clinical molecular diagnostics for thalassemia,human papillomavirus(HPV),and other dis-eases.FHGC could improve hybridization efficiency and r...The flow-through hybridization and gene chip(FHGC)was developed to used in clinical molecular diagnostics for thalassemia,human papillomavirus(HPV),and other dis-eases.FHGC could improve hybridization efficiency and reduce hands-on time,thus improving precision,repro-ducibility,and traceability.Multiple genotypes can be detected simultaneously without incurring high costs.^(1)During the experiment,the polymerase chain reaction(PCR)product or buffer forced through the membrane matrix,PCR products are apprehended by a probe attached to the membrane.展开更多
The major mechanism for ring chromosome formation is thought to result from breakage and reunion at the breakpoints on the long and short arms of a chromosome.This fusion event can produce terminal arm inversions,dele...The major mechanism for ring chromosome formation is thought to result from breakage and reunion at the breakpoints on the long and short arms of a chromosome.This fusion event can produce terminal arm inversions,deletions,and duplications that determine the resulting phenotype.[1] Ring chromosome 13 is relatively uncommon,with an estimated incidence of 1/58,000 live births.展开更多
基金supported by the National Natural Science Foundation of China(No.81102035,and 82060388)Doctor Foundation of Guizhou Provincial People's Hospital(No.GZSYBS[2019]08)+2 种基金Guizhou High-level Innovative Talents Project(No.QKPT[2017]5724-6)Guizhou Department and Platform Talents(No.[2017]5735-31)Science and Technology Department of Guizhou Province(No.QKHJC[2021-396]).
文摘Osteosarcoma (OS) is the most common histological form of primary bone cancer in childhood cancer and young adults. At present, OS is widely investigated because of the interaction between the tumor and bone microenvironment and the effect of such interaction on OS progression and metastasis.1 The connective tissue growth factor (CTGF), also known as cellular communication network factor 2 (CCN2), is a secreted extracellular matrix-associated protein. CTGF is as active as the regulators of signaling activities of several different pathways and an orchestrator of their cross-talk.2 Therefore, we conducted experiments to investigate the effects of CTGF on OS tumor progress and the cross-talk with stromal cells in the tumor microenvironment.
基金supported by the National Natural Science Foundation of China(No.82060388)Science and Technology Department of Guizhou Province(No.QKHJC-ZK[2021-396],QKHJC[2020]1Y424)+2 种基金Healthcare Commission of Guizhou Province(China)(No.GZWJKJ2019-1-192,GZWJKJ2021-310)Guiyang Science and Technology Bureau Guizhou,China(No.ZKH2022-4-3)Guizhou Department and Platform Talents(China)(No.[2018]5766-1).
文摘The flow-through hybridization and gene chip(FHGC)was developed to used in clinical molecular diagnostics for thalassemia,human papillomavirus(HPV),and other dis-eases.FHGC could improve hybridization efficiency and reduce hands-on time,thus improving precision,repro-ducibility,and traceability.Multiple genotypes can be detected simultaneously without incurring high costs.^(1)During the experiment,the polymerase chain reaction(PCR)product or buffer forced through the membrane matrix,PCR products are apprehended by a probe attached to the membrane.
文摘The major mechanism for ring chromosome formation is thought to result from breakage and reunion at the breakpoints on the long and short arms of a chromosome.This fusion event can produce terminal arm inversions,deletions,and duplications that determine the resulting phenotype.[1] Ring chromosome 13 is relatively uncommon,with an estimated incidence of 1/58,000 live births.
