Objective. The aim of this retrospective multicenter study was to assess whether the pre- chemotherapy hemoglobin levels have any impact on the clinical outcome of patients with advanced epithelial ovarian cancer who ...Objective. The aim of this retrospective multicenter study was to assess whether the pre- chemotherapy hemoglobin levels have any impact on the clinical outcome of patients with advanced epithelial ovarian cancer who received a first- line taxane/platinum- based regimen. Methods. The study was conducted on 315 patients who underwent initial surgery followed by taxane/- platinum- based chemotherapy for FIGO stage IIc- IV epithelial ovarian cancer. All the patients had ECOG performance status 0- 1 at presentation. The median follow- up of survivors was 36 months (range, 6- 120 months). Results. The 25% , 50% , and 75% quantiles of hemoglobin levels before starting first line chemotherapy were 10.2, 11.4, and 12.3 g/dl, respectively. Residual disease after initial surgery (>1cmversus ≤ 1cm, P = 0.0013) was the only independent prognostic variable for overall survival. Conversely, hemoglobin levels (< 10.2 g/dl versus 10.2- 11.4 g/dl versus 11.5- 12.3 g/dl versus >12.3 g/dl)were inversely related to overall survival at univariate (P = 0.03) but not at multivariate analysis. Conclusions. This investigation showed that hemoglobin levels before starting first- line taxane/platinum- based chemotherapy are not an independent prognostic factor for overall survival in patients with advanced epithelial ovarian cancer.展开更多
文摘Objective. The aim of this retrospective multicenter study was to assess whether the pre- chemotherapy hemoglobin levels have any impact on the clinical outcome of patients with advanced epithelial ovarian cancer who received a first- line taxane/platinum- based regimen. Methods. The study was conducted on 315 patients who underwent initial surgery followed by taxane/- platinum- based chemotherapy for FIGO stage IIc- IV epithelial ovarian cancer. All the patients had ECOG performance status 0- 1 at presentation. The median follow- up of survivors was 36 months (range, 6- 120 months). Results. The 25% , 50% , and 75% quantiles of hemoglobin levels before starting first line chemotherapy were 10.2, 11.4, and 12.3 g/dl, respectively. Residual disease after initial surgery (>1cmversus ≤ 1cm, P = 0.0013) was the only independent prognostic variable for overall survival. Conversely, hemoglobin levels (< 10.2 g/dl versus 10.2- 11.4 g/dl versus 11.5- 12.3 g/dl versus >12.3 g/dl)were inversely related to overall survival at univariate (P = 0.03) but not at multivariate analysis. Conclusions. This investigation showed that hemoglobin levels before starting first- line taxane/platinum- based chemotherapy are not an independent prognostic factor for overall survival in patients with advanced epithelial ovarian cancer.
