Although stimulus frequency otoacoustic emissions (SFOAEs) have been used as a non-invasive measure of cochlear mechanics, clinical and experimental application of SFOAEs has been limited by difficulties in accurately...Although stimulus frequency otoacoustic emissions (SFOAEs) have been used as a non-invasive measure of cochlear mechanics, clinical and experimental application of SFOAEs has been limited by difficulties in accurately deriving quantitative information from sound pressure measured in the ear canal. In this study, a novel signal processing method for multicomponent analysis (MCA) was used to measure the amplitude and delay of the SFOAE. This report shows the delay-frequency distribution of the SFOAE measured from the human ear. A low level acoustical suppressor near the probe tone significantly suppressed the SFOAE, strongly indicating that the SFOAE was generated at characteristic frequency locations. Information derived from this method may reveal more details of cochlear mechanics in the human ear.展开更多
Positron emission tomography(PET)is a powerful noninvasive imaging tool for phenotyping patients at risk of or with known coronary artery disease(CAD).One of the key advantages over other imaging modalities is its uni...Positron emission tomography(PET)is a powerful noninvasive imaging tool for phenotyping patients at risk of or with known coronary artery disease(CAD).One of the key advantages over other imaging modalities is its unique ability to quantify physiologic processes,including myocardial blood fl ow(in milliliters per minute per gram of myocardium),metabolism,and cardiac receptors,and its high sensitivity for delineating and quantifying molecular targets in vivo using targeted imaging probes.Cardiac PET/CT offers opportunity for a comprehensive noninvasive evaluation of the consequences of atherosclerosis in the coronary arteries and the myocardium.展开更多
Foreign body （FB） removal represents a large part of the work in surgical practice.[1] However,FB removal may often be a surgical challenge because of the nonpalpated and close anatomical relationship of the FB to v...Foreign body （FB） removal represents a large part of the work in surgical practice.[1] However,FB removal may often be a surgical challenge because of the nonpalpated and close anatomical relationship of the FB to vital structures or due to patients with cicatricial diathesis.[2] Retained FBs may result in infection,chronic pain,structural injury,granuloma,and psychological distress,especially with late presentation （more than 1 week from the time of injury）.展开更多
Aim:Hepatocellular carcinoma(HCC)is one of the most common cancers in the world.If left untreated,liver cancer has a poor prognosis with more than 90%of patients dying of the disease within 5 years of diagnosis.The ai...Aim:Hepatocellular carcinoma(HCC)is one of the most common cancers in the world.If left untreated,liver cancer has a poor prognosis with more than 90%of patients dying of the disease within 5 years of diagnosis.The aim of this study is to assess the value of combined radiofrequency ablation(RFA),followed by trans-arterial chemoembolization(TACE)in the management of HCC.Methods:Fifty HCC patients with chronic liver disease were categorized into two groups according to the modality of locoregional treatment:25 HCC patients treated with RFA followed by TACE within 5 days and 25 HCC patients treated with TACE only.Results:Complete response was achieved in 100%and 84%of the HCC patients after 1 month from combined RFA-TACE therapy and TACE only respectively.The rate of objective response after 7 months was 84%and 44%in the RFA-TACE and TACE groups respectively.One year disease free survival rate was 56%and 24%in RFA-TACE and TACE groups respectively,and overall survival rate was 88%in the RFA-TACE group and 80%in the TACE only group.Conclusion:Combined RFA-TACE appears to be an effective modality and superior to TACE only for the treatment of HCC.展开更多
基金Supported in part by research grants from the National Institute of Deafness and Other Communication Disorders(R01 DC 00141 and R03 DC033642)the National Institutes of Health+2 种基金the Research Fund of the American Otological Societythe Medical Research Foundation of OregonVA RR&D Center Grant RCTR-597-0160,Portland,VAMC
文摘Although stimulus frequency otoacoustic emissions (SFOAEs) have been used as a non-invasive measure of cochlear mechanics, clinical and experimental application of SFOAEs has been limited by difficulties in accurately deriving quantitative information from sound pressure measured in the ear canal. In this study, a novel signal processing method for multicomponent analysis (MCA) was used to measure the amplitude and delay of the SFOAE. This report shows the delay-frequency distribution of the SFOAE measured from the human ear. A low level acoustical suppressor near the probe tone significantly suppressed the SFOAE, strongly indicating that the SFOAE was generated at characteristic frequency locations. Information derived from this method may reveal more details of cochlear mechanics in the human ear.
文摘Positron emission tomography(PET)is a powerful noninvasive imaging tool for phenotyping patients at risk of or with known coronary artery disease(CAD).One of the key advantages over other imaging modalities is its unique ability to quantify physiologic processes,including myocardial blood fl ow(in milliliters per minute per gram of myocardium),metabolism,and cardiac receptors,and its high sensitivity for delineating and quantifying molecular targets in vivo using targeted imaging probes.Cardiac PET/CT offers opportunity for a comprehensive noninvasive evaluation of the consequences of atherosclerosis in the coronary arteries and the myocardium.
文摘Foreign body （FB） removal represents a large part of the work in surgical practice.[1] However,FB removal may often be a surgical challenge because of the nonpalpated and close anatomical relationship of the FB to vital structures or due to patients with cicatricial diathesis.[2] Retained FBs may result in infection,chronic pain,structural injury,granuloma,and psychological distress,especially with late presentation （more than 1 week from the time of injury）.
文摘Aim:Hepatocellular carcinoma(HCC)is one of the most common cancers in the world.If left untreated,liver cancer has a poor prognosis with more than 90%of patients dying of the disease within 5 years of diagnosis.The aim of this study is to assess the value of combined radiofrequency ablation(RFA),followed by trans-arterial chemoembolization(TACE)in the management of HCC.Methods:Fifty HCC patients with chronic liver disease were categorized into two groups according to the modality of locoregional treatment:25 HCC patients treated with RFA followed by TACE within 5 days and 25 HCC patients treated with TACE only.Results:Complete response was achieved in 100%and 84%of the HCC patients after 1 month from combined RFA-TACE therapy and TACE only respectively.The rate of objective response after 7 months was 84%and 44%in the RFA-TACE and TACE groups respectively.One year disease free survival rate was 56%and 24%in RFA-TACE and TACE groups respectively,and overall survival rate was 88%in the RFA-TACE group and 80%in the TACE only group.Conclusion:Combined RFA-TACE appears to be an effective modality and superior to TACE only for the treatment of HCC.
