Chronic obstructive pulmonary disease(COPD)is characterized by emphysema and airflow limitation and is one of the leading causes of morbidityand mortalityworldwide.Endoscopic lung volumereduction(ELVR)is a minimally i...Chronic obstructive pulmonary disease(COPD)is characterized by emphysema and airflow limitation and is one of the leading causes of morbidityand mortalityworldwide.Endoscopic lung volumereduction(ELVR)is a minimally invasive technique for patients with severe hyperinflation and advanced emphysema.To date,the most investigated form of ELVR isvalve implantation,which is toplacevalves in all the segments of an emphysematous lobe.However,valve replacements do not achieve adequate lung volume reduction in the,presence of interlobar collateral ventilation(CV).l1 in addition,with the heterogeneity existing withinthe treatment lobe,complete lobar treatment from implants may result in excessive reduction of the less diseased segments.Thus,a more targeted approach of the most severe emphysematous parts of the lobe is warranted.展开更多
基金This work was supported by grants from the National Natural Science Foundationof China(NSFC No.81770072)the“1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYJC18021)”Chengdu Science and Technology Bureau(No.2018SZ0240).
文摘Chronic obstructive pulmonary disease(COPD)is characterized by emphysema and airflow limitation and is one of the leading causes of morbidityand mortalityworldwide.Endoscopic lung volumereduction(ELVR)is a minimally invasive technique for patients with severe hyperinflation and advanced emphysema.To date,the most investigated form of ELVR isvalve implantation,which is toplacevalves in all the segments of an emphysematous lobe.However,valve replacements do not achieve adequate lung volume reduction in the,presence of interlobar collateral ventilation(CV).l1 in addition,with the heterogeneity existing withinthe treatment lobe,complete lobar treatment from implants may result in excessive reduction of the less diseased segments.Thus,a more targeted approach of the most severe emphysematous parts of the lobe is warranted.
